Expect and receive high quality profiling data in days and accelerate your lead discovery projects with SelectScreen Nuclear Receptor Profiling Services from Thermo Fisher Scientific.

Labs from pharmaceutical, biotech, consumer goods, and academic institutions have utilized SelectScreen Nuclear Receptor Profiling Service since their initiation in 2006.

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Why do scientists trust the SelectScreen Services team?

  • Access your data in real-time – as soon as it’s available – through our secure online portal!
  • Projects completed in an average of 7 days
  • All assays and reagents used in the service can be purchased from Thermo Fisher Scientific – allowing you to utilize the same assays in your follow-up studies that our team uses in the service
  • Broad panel of 75 nuclear receptor assays available
  • State-of-the-art compound management system ensures consistently high quality data is delivered for every project
  • Complete Lab Information Management System (LIMS) ensures project traceability and consistency

Project Options

Customize your nuclear receptor based profiling project to get the right data for your research.

Standard service options include:

  • Targets – 20 Cellular Nuclear receptors (39 assays)  and 23 Biochemical Nuclear receptors (36 assays) available
  • Mode – IC50 and/or EC50 determinations

To discuss your Nuclear Receptor profiling project requirements, send us an inquiry


Technology Overview

Currently, biochemical and cellular based Nuclear Receptor assays are available:

  • Biochemical: LanthaScreen Competitive Binding and Coactivator assays
  • Cellular: GeneBLAzer Nuclear Receptor assays

Overview of available formats

LanthaScreen biochemical Competitive Binding AssaysTechnology Overview Protocol and Assay Conditions
LanthaScreen biochemical Coactivator AssaysTechnology Overview Protocol and Assay Conditions
GeneBLAzer cellular assaysTechnology Overview Protocol and Assay Conditions

A stringent validation process ensures the highest quality data possible with each data point performed in duplicate. Strict quality control protocols ensure that any assay results not meeting set specifications will be automatically repeated, this includes a control inhibitor titration for each assay on every plate. To discuss your Nuclear Receptor profiling project requirements, send us an inquiry


Broad Assay Panel

AssayGeneBLAzer Cellular AssayLanthaScreen Biochemical Assay
Cell LineAgonistAntagonistCoactivator AgonistCoactivator Inverse AgonistCoactivator AntagonistCompetitive Binding
ARUAS-bla GripTite 293      
CARN/A      
ER-alphaUAS-bla GripTite 293      
ER-betaUAS-bla GripTite 293      
ERR-alphaUAS-bla HEK 293T      
ERR-betaN/A      
ERR-gammaN/A      
FXRUAS-bla HEK 293T      
GRUAS-bla HEK 293T      
LXR-alphaUAS-bla HEK 293T      
LXR-betaUAS-bla HEK 293T      
MRUAS-bla HEK 293T      
PPAR-alphaN/A      
PPAR-deltaUAS-bla HEK 293T      
PPAR-gammaUAS-bla HEK 293H      
PRUAS-bla HEK 293T      
PXR(SXR)N/A      
RAR-alphaUAS-bla HEK 293T      
RAR-betaUAS-bla HEK 293T      
RAR-gammaUAS-bla HEK 293T      
RXR-alphaUAS-bla HEK 293T      
RXR-betaUAS-bla HEK 293T      
TR-alphaUAS-bla HEK 293T      
TR-betaUAS-bla HEK 293T      
VDRUAS-bla HEK 293T      

Personalized support

Personalized Support

From project beginning to end, you can rely on our Drug Discovery Services project management team to provide frequent project communication via a single point of contact.

Watch this two-minute video to see how our project managers and technical specialists create an exceptional experience for our customers.

If you have already received a quote number, place an order here.