Caspase-8 binds to the death effector domain (DED) of FADD through an analogous DED domain present in tandem in the proform of the caspase-8 protein. Recruitment of caspase-8 to the Fas receptor results in oligomerization of the caspase-8 protein, which in turn drives its autoactivation through "self-cleavage". Activated caspase-8 then activates other downstream caspases including caspase-9, thereby commiting the cell to undergo apoptosis. This antibody also detects the processed forms (42/44kDa, 25kDA, and 14kDa) of caspase-8.
InvitrogenPhospho-Caspase 8 (Ser387) Antibody (10HCLC), ABfinity™ Rabbit Oligoclonal Phospho-Caspase 8 (Ser387) Antibody (10HCLC), ABfinity™ Rabbit Oligoclonal
Cat # 710535
InvitrogenCaspase 8 Monoclonal Antibody (1H10), eBioscience™ Caspase 8 Monoclonal Antibody (1H10), eBioscience™
Cat # 14-9934-82
InvitrogenCaspase 8 Monoclonal Antibody (4-1-20), eBioscience™ Caspase 8 Monoclonal Antibody (4-1-20), eBioscience™
Cat # BMS1102-2
InvitrogenCaspase 8 (Cleaved Asp391) Monoclonal Antibody (S.147.8) Caspase 8 (Cleaved Asp391) Monoclonal Antibody (S.147.8)
Cat # MA5-15054
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