EN2 is thought to have a role in controlling development. In Drosophila, the protein plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. This protein has been implicated in the control of pattern formation during development of the central nervous system.
EN2; engrailed homolog 2; engrailed-2; Homeobox protein en-2; Homeobox protein engrailed-2; Hu-En-2; mo-En-2