The Estrogen Receptor beta (ER beta) protein is approximately 55kD, though multiple isoforms ranging from 36-59kD have been described. Human ER beta was initially cloned and characterized from testis. The size and structure of ER beta is very similar to ER alpha, with the ligand and DNA binding domains being highly conserved, while the amino terminus which serves as the transactivation domain has diverged significantly. Similar in function to ER alpha, ER beta binds to estrogen with a high affinity and regulates estrogen-specific gene activation through direct interaction with estrogen response elements (ERE's).
ER Beta; ER-beta; ESR-Beta; ESR2; estrogen receptor 2 (ER beta); estrogen receptor 2 beta; Estrogen receptor beta; estrogen receptor beta 4; Nuclear receptor subfamily 3 group A member 2; oestrogen receptor beta
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