FOXP3 (FORKHEAD BOX P3) belongs to the FOX protein family and the master regulator in T-Cell development and function. The gene encodes protein which is a member of the forkhead/winged-helix family of transcriptional regulators. It is shown that in human breast and colon cancer cells, expression of FOXP3 is regulated by p53 in response to the DNA damage. FOXP3 is selectively expressed by a subset of CD4+ T cells, known as T regulatory cells, known to suppress T cell activity during response to foreign or self antigen selectively express FOXP3.
AIID; DIETER; enteropathy; Forkhead box protein P3; FOXP3delta7; immune dysregulation; immune dysregulation, polyendocrinopathy, enteropathy, X-linked; immunodeficiency; immunodeficiency, polyendocrinopathy, enteropathy, X-linked; IPEX; JM2; MGC141961; MGC141963; PIDX; polyendocrinopathy; Scurfin; scurfy; X-linked; XPID
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