Antibodies that detect FOXP3 can be used in several scientific applications, including Flow Cytometry, Western Blot, Immunohistochemistry (Paraffin), Immunohistochemistry (Frozen) and Immunocytochemistry. These antibodies target FOXP3 in Human, Mouse, Non-human primate, Rat and Rhesus Monkey samples. Our FOXP3 monoclonal, polyclonal and recombinant monoclonal antibodies are developed in Mouse, Rat, Rabbit and Goat. These antibodies have been verified by Relative expression and Cell treatment to confirm specificity to FOXP3. Find the FOXP3 antibody that fits your needs. Choose from 1 of 112 FOXP3 antibodies, which have been validated in experiments with 7428 publications and 2470 images featured in our data gallery.
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FOXP3 (Forkhead box protein 3) is a member of the forkhead/winged-helix family of transcriptional regulators, highly conserved across mammals, and essential for normal immune homeostasis. FOXP3 is 381 amino acids long, stably and constitutively expressed at a high level in CD25 + CD4 positive regulatory T cells, a low level in CD4-positive/CD25-negative cells, and is absent in CD4-negative/CD8-positive T cells. FOXP3 may be a master regulatory gene, and a more specific marker of regulatory T cells. Defects in the gene encoding FOXP3 protein cause the scurfy phenotype in mice. In humans FOXP3 defects play a role in IPEX syndrome (immune dysfunction, polyendocrinopathy, enteropathy, X-linked syndrome), also known as X-linked autoimmunity-allergic dysregulation (XLAAD) syndrome. Transcript variants of FOXP3 encoding different isoforms have been identified. In human breast and colon cancer cells, expression of FOXP3 is regulated by p53 in response to the DNA damage.
Forkhead box protein P3; Forkhead box protein P3 41 kDa form; Forkhead box protein P3, C-terminally processed; forkhead/winged helix transcription factor 3; Foxp3; MGC141961; MGC141963; RP23-54C14.1; Scurfin; scurfy
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