UGT2B4 belongs to the UDP-glycosyltransferase family. UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme is active on polyhydroxylated estrogens (such as estriol, 4-hydroxyestrone and 2-hydroxyestriol) and xenobiotics (such as 4-methylumbelliferone, 1-naphthol, 4-nitrophenol, 2-aminophenol, 4-hydroxybiphenyl and menthol). It is capable of 6 alpha-hydroxyglucuronidation of hyodeoxycholic acid.
HLUG25; hyodeoxycholic acid; Hyodeoxycholic acid-specific UDPGT; UDP glucuronosyltransferase 2 family, polypeptide B36; UDP glucuronosyltransferase 2 family, polypeptide B4; UDP glycosyltransferase 2 family, polypeptide B4; UDP-glucuronosyltransferase 2B12; UDP-glucuronosyltransferase 2B15; UDP-glucuronosyltransferase 2B36; UDP-glucuronosyltransferase 2B4; UDP-glucuronyltransferase, family 2, beta-4; UDPGT 2B12; UDPGT 2B15; UDPGT 2B36; UDPGT 2B4; UDPGTh-1