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|Tested species reactivity||Mouse|
|Published species reactivity||Mouse, Not Applicable|
|Host / Isotype||Rat / IgG2b|
|Immunogen||C57BL/10 splenic T cells and concanavalin A stimulated C57BL/10 splenocytes|
|Storage buffer||PBS with BSA|
|Contains||0.1% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
CD11b is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement coated particles. It is identical to CR3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the RGD peptide in C3b. CD11b is also a receptor for fibrinogen, factor X, and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. The Mac1 CD11b antigen is present on macrophages, granulocytes, natural killer cells, and blood monocytes. CD11b is expressed on 8% of spleen cells, 44% of bone marrow cells, and less than 1% of thymocytes, and is commonly used as a microglial marker in nervous tissue.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
MIF deficiency does not alter glucose homeostasis or adipose tissue inflammatory cell infiltrates during diet-induced obesity.
RM2828 was used in flow cytometry to study the effects of MIF deficiency in a model of high-fat diet-induced obesity.
|Conine SJ,Cross JV||Obesity (Silver Spring, Md.) (22:418)||2014|
Enhanced GITR/GITRL interactions augment IL-27 expression and induce IL-10-producing Tr-1 like cells.
RM2828 was used in flow cytometry to characterize mice that constitutively expresses the GITR ligand on APCs.
|Carrier Y,Whitters MJ,Miyashiro JS,LaBranche TP,Ramon HE,Benoit SE,Ryan MS,Keegan SP,Guay H,Douhan J,Collins M,Dunussi-Joannopoulos K,Medley QG||European journal of immunology (42:1393)||2012|
|Not Applicable||Not Cited||
Production of IFN-ß during Listeria monocytogenes infection is restricted to monocyte/macrophage lineage.
RM2828 was used in flow cytometry to determine which cells are responsible for IFN-beta expression after infection with Listeria monocytogenes
|Solodova E,Jablonska J,Weiss S,Lienenklaus S||PloS one (6:null)||2011|
CD11 antigen-like family member B; CD11B; CD11B (p170); cell surface glycoprotein MAC-1 alpha subunit; cell surface glycoprotein MAC-1 subunit alpha; complement component receptor 3 alpha-a; complement receptor type 3; CR-3 alpha chain; CR3A; Integrin alpha M; integrin alpha-M; leukocyte adhesion receptor MO1; MAC-1; Mac-1 alpha; MAC1A; macrophage antigen alpha; MGC117044; MO1A; SLEB6
Cd11b; CD11b/CD18; CR3; CR3A; F730045J24Rik; Ly-40; Mac-1; Mac-1a; MAC1