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Help maximize process simplicity and enable savings through filter reduction
The need for innovative single-use technologies for harvest applications that serve the markets for recombinant proteins, monoclonal antibodies (mABs), and bioengineered vaccines remains high. With a growing need for optimization of processes requiring high cell densities and more efficient processing steps, customers are seeking robust solutions in the harvest step to address unmet needs in the workflow.
These customer challenges have led to the creation of the DynaSpin Single-Use Centrifuge. This product offers superior separation and next-generation automation, adding exceptional value to drug manufacturers. The DynaSpin Centrifuge aims to address industry needs with specially designed ergonomic hardware, consumables, and simple software, helping to decrease both process and facility requirements for the harvest unit operation.
Next-generation harvest technology
The DynaSpin Centrifuge is a scalable solution that allows for process volumes from 50 to 5,000 L, offering efficiency, especially at larger scales where multiple units can be organized in a daisy chain to optimize volumetric pull-down time from the bioreactor.
The DynaSpin Centrifuge can replace the first stage of depth filtration with single-use centrifugation, helping reduce the quantity of required clarifying filters. This system supports harvest efficiency, allowing a singular step to separate out particulates and enabling customers to accomplish what a normal two-stage depth filtration does at a reduced cost, footprint, and consumable usage. The DynaSpin Centrifuge helps bring value by decreasing the number of depth filters, in turn facilitating a reduced requirement for inventory and warehouse storage, and supporting sustainability by reducing filter and buffer waste.
Watch this short video to see the design and function of the DynaSpin Centrifuge
Unlock the secrets of bioprocessing scale-up through media optimization and commercialisation. Learn how to tackle common challenges in scaling mAb manufacturing processes.
Key features and benefits
The DynaSpin Single-Use Centrifuge fills a key gap in bioproduction workflows by offering a competitive solution to the harvest application. Intensified upstream processes and the adoption of large-scale single-use bioreactors places increased stress on downstream unit operations. The DynaSpin Centrifuge demonstrates an exceptional value-add in the single-use bioproduction workflow.
Features and benefits include:
Process efficiency with fewer filters
- Designed to reduce depth-filter surface area requirements across all scales
- Can replace primary filtration and reduce burden on secondary filtration
- Helps mitigate bottlenecks in large-scale bioreactors
- High efficiency helps make harvesting less labor-intensive
Risk mitigation and quality control
- Simple installation and operation
- Closed system reduces process risk
- Plug-and-play automation functionalities allow for increased process monitoring and quality control
- Single-use consumable rotor for convenience and safety
Process sustainability
- Smaller operational footprint requirement than traditional approaches
- Reducing filter usage helps reduce the amount of plastic waste generated by each batch
Consumables
Single-Use Centrifuge Rotor
The DynaSpin Single-Use Centrifuge features a unique, slide-in-place Magnetic Coupling Rotor and pump design, allowing for scalability from volumes between 50 and 5,000 L. This facilitates increased efficiency, especially at larger volumes. Designed for convenience and safety, the DynaSpin Centrifuge enables up to 25% harvest cost savings and 70% less filter waste relative to traditional depth filtration workflows*.
*Internal data on file
Line sets secured by BioTitan Retention Device
All the tubing line sets on the DynaSpin Single-Use Centrifuge come equipped with the BioTitan Retention Device. A replacement to traditional cable ties, the BioTitan Retention Device offers enhanced reliability and integrity of the assembly with a 360-degree seal. With zero leaks reported since its 2021 launch, the BioTitan Retention Device offers superior performance.
Automation
The DynaSpin centrifuge is equipped with novel automation functionality which truly sets it apart from existing solutions. The design was crafted with ease of use in mind, exhibiting plug-and-play technology. Further value is apparent when operational efficiency is driven by reducing cleanroom footprint and labor associated with setup time. The DynaSpin centrifuge enables compliance with the Code of Federal Regulations (CFR) Part 11, making data monitoring and archiving possible for the end-user.
Additional centrifuge solutions for bioprocessing
Thermo Scientific batch centrifuges offer clean, fast, and high yield bio separation across all applications, ranging from R&D to large scale production of biologics, recombinant protein, vaccines, cell therapies, veterinary medicines, and biofuels. Find centrifuge solutions for harvesting, clarification, and purification steps in your workflow, including single-use, sterilized centrifuge systems.
Additional bioprocessing resources
Discover areas where you can cut costs and gain efficiency using our integrated calculator.
For research use or further manufacturing. Not for diagnostic use or direct administration into humans or animals.