Thermo Scientific™

PDPH (3-(2-pyridyldithio)propionyl hydrazide)

Catalog number: 22301
Thermo Scientific™

PDPH (3-(2-pyridyldithio)propionyl hydrazide)

Catalog number: 22301
Catalog Number
22301
Unit Size
50 mg
Price (USD)
Price: 233.00
Your Price:
Availability
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Quantity
Catalog NumberUnit SizePrice (USD)AvailabilityQuantity
2230150 mg
Price: 233.00
Your Price:
***
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Thermo Scientific Pierce PDPH is a short, pyridyldithiol-and-hydrazide crosslinker for reversibly conjugating sulfhydryls (cysteines) to carbonyls (aldehyde or ketones, such as those formed by oxidation of glycoprotein carbohydrates).

Features of PDPH :

Reactive groups: pyridyldisulfide and hydrazide
Reactive toward: sulfhydryl groups and carbonyl (aldehyde) groups
• Short (9.2A), sulfhydryl-to-aldehyde crosslinker with disulfide bond spacer arm (cleavable)
• Pyridyldithiol group results in attachment to sulfhydryls via disulfide bond, which can be cleaved with DTT, TCEP or other reducing agents
• Hydrazide group conjugates to oxidized sugars of glycoproteins and carbohydrates
• Use sodium meta-periodate to oxidize glycosylation (e.g., sialic acid) to reactive aldehyde groups
• Use with EDC to conjugate primary amine of hydrazide group to carboxyl groups

Product References:
Crosslinker Application Guide -- search for recent literature references for this product
For Research Use Only. Not for use in diagnostic procedures.

Specifications

Product Line
Pierce™
Labeling Method
Chemical Labeling
Crosslinker Type
Heterobifunctional
Reactive Moiety
Maleimide, Pyridyldisulfide
Spacer
Cleavable, Short
Form
Powder
Quantity
50 mg
Solubility
DMF, DMSO
Product Type
Crosslinker

Contents & Storage

Upon receipt store desiccated at 4°C. Product is shipped at ambient temperature.