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Bcl2 Monoclonal Antibody (1B5B9)
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Product Details
66799-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1B5B9
Immunogen
Bcl2 Fusion Protein Ag24261 (1-237 aa encoded by NM-009741)
Conjugate
Form
Liquid
Concentration
1.39 mg/mL
Amount
208.5 µg
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MAQAGRTGY DNREIVMKYI HYKLSQRGYE WDAGDADAAP LGAAPTPGIF SFQPESNPMP AVHRDMAART SPLRPLVATA GPALSPVPPV VHLTLRRAGD DFSRRYRRDF AEMSSQLHLT PFTARGRFAT VVEELFRDGV NWGRIVAFFE FGGVMCVESV NREMSPLVDN IALWMTEYLN RHLHTWIQDN GGWDAFVELY GPSMRPLFDF SWLSLKTLLS LALVGACITL GAYLGHK (1-237 aa encoded by NM-009741)
Target Information
BCL-2 is a key regulator of apoptosis that functions to either inhibit or promote cell death. The BCL-2 family members are also characterized by dimerizing to further modulate apoptosis. Bag1, for example, has been found to form a heterodimer with BCL-2 resulting in the enhancement of the anti-apoptotic effect of BCL-2. Bax and Bak have been shown to play a critical role in cytochrome c release from mitochondria and thus initiate apoptosis. Bax exerts a pro-apoptotic rather than an anti-apoptotic effect on cells. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. In most follicular lymphomas, neoplastic germinal centers express high levels of BCL-2 alpha protein, whereas the normal or hyperplastic germinal centers are negative. Two transcript variants of BCL-2, produced by alternate splicing, differ in their C-terminal ends. The overexpression of BCL-2 has been linked to human cancers such as B-cell lymphoma and prostate cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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