ImmunoCAP Specific IgG
Marker of Exposure to Antigens

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With ImmunoCAP™ Specific IgG tests, the concentration of circulating allergen-specific IgG antibodies in human serum or plasma can be determined.1 These antibodies are part of the natural defense system of the body and develop in response to contact with foreign substances. The ImmunoCAP portfolio offers testing for common environmental allergens/antigens that may cause an exaggerated immune response,2 e.g., bacterial, fungal, animal, plant, and chemical substances.3

Measuring specific IgG antibodies may provide a range of valuable clinical information in several fields.

Allergic disease

In allergic disease, these are some examples of how specific IgG test results are used:

  • In clinical studies with asthma, rhinitis, urticaria, eczema, and gastrointestinal disorders.
  • As a marker for exposure in interstitial lung diseases, e.g., extrinsic allergic alveolitis (aka hypersensitivity pneumonitis), invasive aspergillosis, and allergic bronchopulmonary invasive aspergillosis (ABPA).2,4,5
  • As a marker for high exposure to occupational allergens, e.g., chemicals, which may lead to hypersensitivity pneumonitis.6

There is no common cut-off value for above normal levels of circulating specific IgG antibodies, as these are markers for allergen exposure, which may not be directly related to the disease and will depend on the local environment and levels of exposure.7

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References
  1. Directions for use. ImmunoCAP IgG.
  2. Costabel, U., F. Bonella, and J. Guzman, Chronic hypersensitivity pneumonitis. Clin Chest Med, 2012. 33(1): p. 151-63.
  3. Baur, X., A. Fischer, and L.T. Budnik, Spotlight on the diagnosis of extrinsic allergic alveolitis (hypersensitivity pneumonitis). Journal of occupational medicine and toxicology (London, England), 2015. 10: p. 15-15.
  4. Sterclova, M., M. Vasakova, and M. Metlicka, Significance of specific IgG against sensitizing antigens in extrinsic allergic alveolitis: serological methods in EAA. Rev Port Pneumol, 2011. 17(6): p. 253-9.
  5. Van Hoeyveld, E., L. Dupont, and X. Bossuyt, Quantification of IgG antibodies to Aspergillus fumigatus and pigeon antigens by ImmunoCAP technology: an alternative to the precipitation technique? Clin Chem, 2006. 52(9): p. 1785-93.
  6. Baur, X., Hypersensitivity pneumonitis (extrinsic allergic alveolitis) induced by isocyanates. J Allergy Clin Immunol, 1995. 95(5 Pt 1): p. 1004-10.
  7. Tan YH1, Ngan CC, Huang SW, Loo CM, Low SY. Specific Serum Immunoglobulin G (IgG) Levels Against Antigens Implicated in Hypersensitivity Pneumonitis in Asymptomatic Individuals. Ann Acad Med Singapore. 2019 Jan;48(1):36-38