Tradeshow
Jun 18, 2022 - Jun 23, 2022
Town and Country Hotel and Conference Center | 500 Hotel Circle North, San Diego, CA 92108
HPLC 2022

We loved connecting with you in San Diego for HPLC 2022 after a few years without the conference. We’ve uploaded our posters for those of you who may have missed the conference and for those of you who are interested in taking a deeper look.

Want to find out more about our solutions? We would love to hear from you! Please let us know and we’ll put you in touch with one of our experts.


Vendor workshops


Large Molecule Separations – Innovative Chromatographic Solutions from Peptides to RNA

In this presentation, we will not only show how µPAC HPLC columns can be utilized for extra-high separation performance, pushing peak capacity and resolution, but also how they can help improve reproducibility of analysis and robustness of the analytical workflow.

The µPAC HPLC column is not prepared using slurry packing of particles, but rather uses a photo-lithographic process to create a pillar-based geometrical pattern. This means that the separation channels formed always contain the same number of pillars, which are always located at the same well defined and perfectly ordered position, resulting in virtually identical columns.


The role of HPLC in mRNA analysis

Featuring Jacob Fairchild, Ph.D, Senior Scientist, Moderna

Jacob Fairchild, Ph.D, of Moderna describes the potential of mRNA modalities as vaccines and therapeutics. The development of one of the first mRNA vaccines was made successful by understanding the critical quality attributes of mRNA drug products, which enabled effective deployment around the globe. Jacob will focus on the role HPLC analysis played in addressing analytical challenges of mRNA analysis. HPLC and other robust analytical methods coupled with stringent manufacturing controls are necessary to ensure mRNA stability and high activity in LNP delivery systems.

Oral presentations


Monday, June 20

TimeTitle
Session
4:45 p.m.

Recent Developments in the Synthesis of High-Performance Anion-Exchange Materials Based on Hyperbranched Polymers

Speaker: Christopher Pohl, CAP Chromatography Consulting

Session 4A. Monday Parallel Session: Column Technologies – 1

Keynote Lecture

4:45 p.m.

Characterization and Quantification of Lipid Nanoparticle components and Their Degradants in Vivo Using an LC-HRAM MS Platform

Speakers: Reiko Kiyonami, Ralf Tautenhahn, Min Du, Sinae Lee, Evgenia Verovskaya, Jason Potter

Location: Palm Rooms 4-5-6

Session 4D. Monday Parallel Session: Pharmaceutical Development

Keynote Lecture

Tuesday, June 21

TimeTitle
Session
10:15 a.m.

High Aspect Ratio Pillar Array Columns for Deep Proteome Profiling at Moderate LC Pump Pressures

Speakers: Jeff Op de Beeck, Natalie Van Landuyt, David Bergen, Romain Huguet, Joshua Silveira, Xuefei Sun, Brandon Robson, Paul Jacobs

Session 6B. Tuesday Parallel Session: Microscale Separation – I

Wednesday, June 22

TimeTitle
Session
12:15 - 12:30 p.m.

From Bulk to Single-cell Analysis: The New Generation of Liquid Chromatography and Columns for Ultra-sensitive LCMS

Speakers: Runsheng Zheng, Xuefei Sun, Christopher Pynn, Alec Valenta, Alexander Boychenko

Session 11C. Wednesday Parallel Session: Proteomics – I
5:45 – 6:00 p.m.

Comparison of Two Quantification Strategies in TDM Applicable to Two-Dimensional Liquid Chromatography Coupled to Mass Spectrometry

Speakers: Maria Grubner, Mauro De Pra, Giorgia Greco, Tobias Fehrenbach, Stephan Meding, Markus M. Martin, Frank Steiner

Session 12A. Wednesday Parallel Session: Multidimensional Separations – I
4:15 p.m.

Characterization of Lipid Nanoparticle (LNP) Composition Using UHPLC-CAD

Speakers: Sissi White, Ken Cook, Sara Carillo, Jonathan Bones, Min Du
Location: Palm Rooms 4-5-6

Session 12D. Wednesday Parallel Session: Biopharmaceuticals: Forward Looking

Keynote Lecture

5:15 p.m.

New Insights Into the Chromatography mechanisms of Ion-Exchange Charge Variant Analysis: Dispelling Myths and Providing Guidance for Robust Method Optimization

Speakers: Shanhua Lin, Alexander Schwahn, Chris Pohl, Julia Baek, Ken Cook

Session 12D. Wednesday Parallel Session: Biopharmaceuticals: Forward Looking

Keynote Lecture

Thursday, June 23

TimeTitle
Session
11:15 a.m.

Optimization of mRNA Sequence Analysis by UHPLC/HRMS

Speakers: Ken Cook, Mark Dickman, Andre Williamson

Session 15C. Thursday Parallel Session: Nucleic Acids and Oligos – II

Posters


Poster #

Title

Authors

Session

P-M-203Combining mass spectra, retention time modeling, and charged aerosol detection for unambiguous peak annotation and uniform-response quantitation in polysorbate profilingDenis Andrei Ispan, Sara Carillo, Jonathan Bones, Ken Cook, Frank Steiner and Mauro De PraMonday
P-M-413QA/QC Analytical Methods for the Structural Analysis of Biotherapeutic VirusesEstee Toole , Ross Pritchett , Kate Erickson , Craig Dufresne , Ken Cook and Alexander IvanovMonday
P-T-507Analytical Method Transfer to Thermo Fisher Vanquish UHPLCNolan DeanTuesday
P-T-714Assay of tromethamine in pharmaceutical formulationsSachin Patil and Jeffrey RohrerTuesday
P-T-732Automated HPLC method development and robustness test for abacavir, lamivudine, dolutegravir and their related compounds in Triumeq drug productXuepu Li, Brooks, Matt and Min DuTuesday
P-T-734Hight-throughput analysis of oligonucleotides using a single quadrupole mass spectrometer for quality controlDennis Koehler and Mauro De PraTuesday
P-W-1007HPLC determination of biogenic amines in beer by AQC derivatizationMichaela Scherz, Mauro De Pra, Sylvia Grosse and Frank SteinerWednesday
P-W-1009Determination of quaternary amine polar pesticides using improved cation-exchange separation technology combined with suppressed conductivity and tandem mass spectrometry detectionSachin Patil, Terri Christison, John Madden and Jeffrey RohrerWednesday
P-W-1215Automated UHPLC method development and robustness test for mebendazole and related impuritiesSoo Hyun Park, Mauro De Pra, Sylvia Grosse, Carsten Paul, Alec Valenta and Frank SteinerWednesday
P-W-1216Simultaneous reversed-phase and anion-exchange method scouting for mRNA impurity determinationMauro De Pra, Denis A. Ispan, Carsten Paul, Frank Steiner and Alec ValentaWednesday

Vendor workshops


Large Molecule Separations – Innovative Chromatographic Solutions from Peptides to RNA

In this presentation, we will not only show how µPAC HPLC columns can be utilized for extra-high separation performance, pushing peak capacity and resolution, but also how they can help improve reproducibility of analysis and robustness of the analytical workflow.

The µPAC HPLC column is not prepared using slurry packing of particles, but rather uses a photo-lithographic process to create a pillar-based geometrical pattern. This means that the separation channels formed always contain the same number of pillars, which are always located at the same well defined and perfectly ordered position, resulting in virtually identical columns.


The role of HPLC in mRNA analysis

Featuring Jacob Fairchild, Ph.D, Senior Scientist, Moderna

Jacob Fairchild, Ph.D, of Moderna describes the potential of mRNA modalities as vaccines and therapeutics. The development of one of the first mRNA vaccines was made successful by understanding the critical quality attributes of mRNA drug products, which enabled effective deployment around the globe. Jacob will focus on the role HPLC analysis played in addressing analytical challenges of mRNA analysis. HPLC and other robust analytical methods coupled with stringent manufacturing controls are necessary to ensure mRNA stability and high activity in LNP delivery systems.

Oral presentations


Monday, June 20

TimeTitle
Session
4:45 p.m.

Recent Developments in the Synthesis of High-Performance Anion-Exchange Materials Based on Hyperbranched Polymers

Speaker: Christopher Pohl, CAP Chromatography Consulting

Session 4A. Monday Parallel Session: Column Technologies – 1

Keynote Lecture

4:45 p.m.

Characterization and Quantification of Lipid Nanoparticle components and Their Degradants in Vivo Using an LC-HRAM MS Platform

Speakers: Reiko Kiyonami, Ralf Tautenhahn, Min Du, Sinae Lee, Evgenia Verovskaya, Jason Potter

Location: Palm Rooms 4-5-6

Session 4D. Monday Parallel Session: Pharmaceutical Development

Keynote Lecture

Tuesday, June 21

TimeTitle
Session
10:15 a.m.

High Aspect Ratio Pillar Array Columns for Deep Proteome Profiling at Moderate LC Pump Pressures

Speakers: Jeff Op de Beeck, Natalie Van Landuyt, David Bergen, Romain Huguet, Joshua Silveira, Xuefei Sun, Brandon Robson, Paul Jacobs

Session 6B. Tuesday Parallel Session: Microscale Separation – I

Wednesday, June 22

TimeTitle
Session
12:15 - 12:30 p.m.

From Bulk to Single-cell Analysis: The New Generation of Liquid Chromatography and Columns for Ultra-sensitive LCMS

Speakers: Runsheng Zheng, Xuefei Sun, Christopher Pynn, Alec Valenta, Alexander Boychenko

Session 11C. Wednesday Parallel Session: Proteomics – I
5:45 – 6:00 p.m.

Comparison of Two Quantification Strategies in TDM Applicable to Two-Dimensional Liquid Chromatography Coupled to Mass Spectrometry

Speakers: Maria Grubner, Mauro De Pra, Giorgia Greco, Tobias Fehrenbach, Stephan Meding, Markus M. Martin, Frank Steiner

Session 12A. Wednesday Parallel Session: Multidimensional Separations – I
4:15 p.m.

Characterization of Lipid Nanoparticle (LNP) Composition Using UHPLC-CAD

Speakers: Sissi White, Ken Cook, Sara Carillo, Jonathan Bones, Min Du
Location: Palm Rooms 4-5-6

Session 12D. Wednesday Parallel Session: Biopharmaceuticals: Forward Looking

Keynote Lecture

5:15 p.m.

New Insights Into the Chromatography mechanisms of Ion-Exchange Charge Variant Analysis: Dispelling Myths and Providing Guidance for Robust Method Optimization

Speakers: Shanhua Lin, Alexander Schwahn, Chris Pohl, Julia Baek, Ken Cook

Session 12D. Wednesday Parallel Session: Biopharmaceuticals: Forward Looking

Keynote Lecture

Thursday, June 23

TimeTitle
Session
11:15 a.m.

Optimization of mRNA Sequence Analysis by UHPLC/HRMS

Speakers: Ken Cook, Mark Dickman, Andre Williamson

Session 15C. Thursday Parallel Session: Nucleic Acids and Oligos – II

Posters


Poster #

Title

Authors

Session

P-M-203Combining mass spectra, retention time modeling, and charged aerosol detection for unambiguous peak annotation and uniform-response quantitation in polysorbate profilingDenis Andrei Ispan, Sara Carillo, Jonathan Bones, Ken Cook, Frank Steiner and Mauro De PraMonday
P-M-413QA/QC Analytical Methods for the Structural Analysis of Biotherapeutic VirusesEstee Toole , Ross Pritchett , Kate Erickson , Craig Dufresne , Ken Cook and Alexander IvanovMonday
P-T-507Analytical Method Transfer to Thermo Fisher Vanquish UHPLCNolan DeanTuesday
P-T-714Assay of tromethamine in pharmaceutical formulationsSachin Patil and Jeffrey RohrerTuesday
P-T-732Automated HPLC method development and robustness test for abacavir, lamivudine, dolutegravir and their related compounds in Triumeq drug productXuepu Li, Brooks, Matt and Min DuTuesday
P-T-734Hight-throughput analysis of oligonucleotides using a single quadrupole mass spectrometer for quality controlDennis Koehler and Mauro De PraTuesday
P-W-1007HPLC determination of biogenic amines in beer by AQC derivatizationMichaela Scherz, Mauro De Pra, Sylvia Grosse and Frank SteinerWednesday
P-W-1009Determination of quaternary amine polar pesticides using improved cation-exchange separation technology combined with suppressed conductivity and tandem mass spectrometry detectionSachin Patil, Terri Christison, John Madden and Jeffrey RohrerWednesday
P-W-1215Automated UHPLC method development and robustness test for mebendazole and related impuritiesSoo Hyun Park, Mauro De Pra, Sylvia Grosse, Carsten Paul, Alec Valenta and Frank SteinerWednesday
P-W-1216Simultaneous reversed-phase and anion-exchange method scouting for mRNA impurity determinationMauro De Pra, Denis A. Ispan, Carsten Paul, Frank Steiner and Alec ValentaWednesday

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Transfer methods from HPLC to UHPLC conditions and calculate the new gradient table, adjust sample volumes and run times if applicable.

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