Our extensive range of hit-to-lead heterocyclic building blocks are specifically designed for lead optimization through SAR development.

Key features:

  • Over 300 different heterocyclic ring systems—adds to the pharmacophoric profile of your target molecules
  • All synthetically useful functional groups—facilitates the full breadth of chemical synthesis techniques
  • Ring regioisomers—enables systematic exploration of structural diversity space and broadens intellectual property protection
  • Minimal substitution—provides easier interpretation of SAR

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The table below provides examples of our systematic approach, where a tick represents the available functional groups for the ring system shown.

 Functional group ring system
 
CO2H     
COCI     
SO2CI     
CHO     
CHOCH2Br     
NCO     
NCS     
CH2Br     
CH2OH     
Br     
I     
B{OH}2     
CH2NH2     
NH2     

The table above provides examples of the systematic approach taken where a tick represents our offering for that functional group for the corresponding ring system.


We routinely introduce new products into our portfolio. Discover a selection of the latest compounds now available in the Maybridge building blocks portfolio:

New compounds available in the Maybridge building blocks portfolio

5-trifluoromethylpyridin-3-yl-boronic acid

(5-Trifluoromethylpyridin-3-yl) boronic acid

1-boc-azetidine-3-carboxylic acid

1-Boc-azetidine-3-carboxylic acid

 
1-boc-4-aminomethyl-piperidine

1-Boc-4-(aminomethyl)-piperidine

 
1-boc-azetidine-3-methanol

1-Boc-azetidine-3-methanol

2-amino-5-chloropyrimidine
2-Amino-5-cloropyrimidine
 
2-chloropyrimidine-5-sulfonyl

2-Chloropyrimidine-5-sulfonyl

 
3-n-boc-2-aminoethyl-azetidine

3-(N-Boc)-(2-aminoethyl)-azetidine

4-pyrimidinecarboxaldehyde

4-Pyrimidinecarboxaldehyde

6-bromoisoquinoline

6-Bromoisoquinoline

n-boc-piperidine-4-carbonitrile

N-Boc-piperidine-4-carbonitrile

5-aminomethyl-4-methylthiazole

5-(Aminomethyl)-4-methylthiazole

1,3-Benzothiazole-6-carboxaldehyde

1,3-Benzothiazole-6-carboxaldehyde

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