Early research in developmental timing in C. elegans led to the discovery of lin-4, the first microRNA gene (Lee 1993, Wightman 1993). Since then, miRNAs have been implicated in developmental processes including embryogenesis, differentiation, developmental timing, organogenesis, growth control, and programmed cell death (see Alvarez-Garcia 2005 for a review). Current interest in miRNA regulation of human embryonic stem cells.
Additional Learning Topics
Interesting Review Articles
Calin, G.A. and Croce, C.M. MicroRNA Signatures in Human Cancers. Nature Reviews Cancer. 2006; 6(11):857-66.
Lu, J., et al. MicroRNA Expression Profiles Classify Human Cancers. Nature. 2005; 435, 834–838.
Mattick, JS. A New Paradigm for Developmental Biology. Journal of Experimental Biology. May 2007; 210: 1526 - 1547.
Alvarez-Garcia I. and Miska, EA. MicroRNA Functions in Animal Development and Human Disease. Development. 2005; 132 (21): .4653-4662.
Calin, G.A., et al. MicroRNA Profiling Reveals Distinct Signatures in B Cell Chronic Lymphocytic Leukemias. Proc. Natl Acad. Sci. 2004; 101: 11755–11760.
Croce, MA., et. al. MicroRNA Expression Abnormalities in Pancreatic Endocrine and Acinar Tumors Are Associated With Distinctive Pathologic Features and Clinical Behavior. Journal of Clinical Oncology. 2006; 24: 4677-4684.
He, L., et al. A microRNA Polycistron as a Potential Human Oncogene. Nature 2005; 435: 828-833.
Lecellier, C.H., et. al. A Cellular microRNA Mediates Antiviral Defense in Human Cells. Science. 2005; 308: 557–560.
Lee, RC., et. al. The C. elegans Heterochronic Gene lin-4 Encodes Small RNAs with Antisense Complementarity to lin-14. Cell. 1993;75: 843 -854.
Lu, J., et al. MicroRNA Expression Profiles Classify Human Cancers. Nature. 2005; 435: 834–838.
Wightman, B., et. al. Posttranscriptional Regulation of the Heterochronic Gene lin-14 by lin-4 Mediates Temporal Pattern Formation in C. elegans. Cell. 1993; 75: 855 -862.