The protein encoded by this gene belongs to the iodothyronine deiodinase family. It activates thyroid hormone by converting the prohormone thyroxine by outer ring deiodination to bioactive 3,3',5-triiodothyronine residues encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence , which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in multiple transcript variants encoding different isoforms.
5DII; deiodinase-2; deiodonase-2; DIO2; DIOII; iodothyronine type II deiodinase; ITDI2; thyroxine deiodinase, type II; TXDI2; Type 2 DI; type 2 iodothyronine deiodinase; Type II iodothyronine deiodinase; type-II 5' deiodinase; Type-II 5'-deiodinase; type-II 5'deiodinase