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Invitrogen

Kir6.1 (KCNJ8) Monoclonal Antibody (N366/60)

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Kir6.1 (KCNJ8) Monoclonal Antibody (N366/60)

Product Details

MA5-27679

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunohistochemistry (PFA fixed) (IHC (PFA))

1:100
-

Immunocytochemistry (ICC/IF)

1:100
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

N366/60

Immunogen

Fusion protein amino acids 306-424 (Cytoplasmic C-terminus) of rat Kir6.1
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein G

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.1% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2735240

Product Specific Information

A 1:100 dilution of MA5-27679 was sufficient for detection of Kir6.1 in 20 µg of mouse brain lysate by ECL immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. |Detects approximately 45kDa.

This antibody was formerly sold as clone S366-60.

Target Information

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. KCNJ8 is an integral membrane protein and inward-rectifier type potassium channel. KCNJ8, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins.Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: inward rectifier K(+) channel Kir6.1; inwardly rectifier K(+) channel Kir6.1; Inwardly rectifying potassium channel gene, subfamily J-8 (ATP sensitive); inwardly rectifying potassium channel KIR6.1; potassium channel, inwardly rectifying subfamily J member 8; potassium voltage-gated channel subfamily J member 8; unnamed protein product

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Gene Aliases: gnite; KIR6.1; slmbr; sltr; uKATP-1; UKATP1

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UniProt ID: (Human) Q15842, (Mouse) P97794, (Rat) Q63664

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Entrez Gene ID: (Human) 3764, (Mouse) 16523, (Rat) 25472

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Function(s)
inward rectifier potassium channel activity protein binding ATP binding ATP-activated inward rectifier potassium channel activity sulfonylurea receptor binding cation-transporting ATPase activity voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
Process(es)
kidney development potassium ion transport transmembrane transport potassium ion transmembrane transport inorganic cation import across plasma membrane membrane repolarization during ventricular cardiac muscle cell action potential regulation of presynaptic membrane potential transport across blood-brain barrier potassium ion import across plasma membrane action potential blood vessel development response to hypoxia microglial cell activation vasculature development regulation of heart rate adaptive immune response response to ischemia heart morphogenesis ventricular cardiac muscle tissue development apoptotic process response to stress inflammatory response heart development regulation of blood pressure cell proliferation determination of adult lifespan protein secretion response to xenobiotic stimulus phloem or xylem histogenesis gene expression fatty acid transport transmission of nerve impulse establishment of cell polarity response to lipopolysaccharide response to insulin response to ATP response to cytokine response to endoplasmic reticulum stress p38MAPK cascade vasodilation response to exogenous dsRNA NLRP3 inflammasome complex assembly fat cell differentiation fibroblast proliferation neurological system process neuromuscular process synaptic growth at neuromuscular junction neuron apoptotic process defense response to virus cardiac pacemaker cell differentiation atrioventricular node cell differentiation coronary vasculature development glutamate secretion, neurotransmission CAMKK-AMPK signaling cascade calcium ion transmembrane transport circulatory system development reactive gliosis response to resveratrol
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