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Kir6.1 (KCNJ8) Monoclonal Antibody (N366/60), PE

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Kir6.1 (KCNJ8) Monoclonal Antibody (N366/60), PE

Product Details

MA5-45744

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunohistochemistry (IHC)

Assay-dependent
-

Immunocytochemistry (ICC/IF)

1:100
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

N366/60

Immunogen

Fusion protein amino acids 306-424 (Cytoplasmic C-terminus) of rat Kir6.1
View immunogen

Conjugate

PE PE PE

Excitation/Emission Max

565/576 nm View spectra spectra

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein G

Storage buffer

95.46mM phosphate/2.48mM MES, pH 7.4, with 2mM EDTA

Contains

no preservative

Storage conditions

4°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2932198

Product Specific Information

A 1:100 dilution of MA5-45744 was sufficient for detection of Kir6.1 in 20 µg of mouse brain lysate by ECL immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. |Detects approximately 45kDa.

This antibody was formerly sold as clone S366-60.

Target Information

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. KCNJ8 is an integral membrane protein and inward-rectifier type potassium channel. KCNJ8, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins.Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ATP-sensitive inward rectifier potassium channel 8; Inward rectifier K(+) channel Kir6.1; inwardly rectifier K(+) channel Kir6.1; Inwardly rectifying potassium channel gene subfamily J-8 (ATP sensitive); Inwardly rectifying potassium channel gene, subfamily J-8 (ATP sensitive); inwardly rectifying potassium channel KIR6.1; Potassium channel, inwardly rectifying subfamily J member 8; potassium inwardly-rectifying channel, subfamily J, member 8; potassium voltage-gated channel subfamily J member 8; uKATP-1; unnamed protein product

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Gene Aliases: AI448900; gnite; KCNJ8; KIR6.1; slmbr; sltr; uKATP-1; UKATP1

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UniProt ID: (Human) Q15842, (Mouse) P97794, (Rat) Q63664

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Entrez Gene ID: (Human) 3764, (Mouse) 16523, (Rat) 25472

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Function(s)
inward rectifier potassium channel activity protein binding ATP binding ATP-activated inward rectifier potassium channel activity sulfonylurea receptor binding cation-transporting ATPase activity voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization voltage-gated ion channel activity G-protein activated inward rectifier potassium channel activity ion channel transporter
Process(es)
action potential blood vessel development response to hypoxia microglial cell activation kidney development vasculature development regulation of heart rate adaptive immune response response to ischemia heart morphogenesis ventricular cardiac muscle tissue development ion transport potassium ion transport apoptotic process response to stress inflammatory response heart development regulation of blood pressure cell proliferation determination of adult lifespan protein secretion response to xenobiotic stimulus gene expression fatty acid transport transmission of nerve impulse establishment of cell polarity response to lipopolysaccharide response to insulin response to ATP response to cytokine ion transmembrane transport regulation of ion transmembrane transport response to endoplasmic reticulum stress p38MAPK cascade vasodilation response to exogenous dsRNA NLRP3 inflammasome complex assembly fat cell differentiation fibroblast proliferation neurological system process neuromuscular process synaptic growth at neuromuscular junction defense response to virus cardiac pacemaker cell differentiation atrioventricular node cell differentiation coronary vasculature development glutamate secretion, neurotransmission CAMKK-AMPK signaling cascade calcium ion transmembrane transport potassium ion transmembrane transport circulatory system development inorganic cation transmembrane transport membrane repolarization during ventricular cardiac muscle cell action potential regulation of presynaptic membrane potential reactive gliosis transport across blood-brain barrier response to resveratrol potassium ion import across plasma membrane transport response to pH potassium ion import
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