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Invitrogen
Kir6.1 (KCNJ8) Monoclonal Antibody (N366/60), APC
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FIGURE: 1 / 3
Kir6.1 (KCNJ8) Antibody (MA5-45741) in ICC/IF
Immunocytochemistry/Immunofluorescence analysis using human neuroblastoma cells. Fixation involved 4% Formaldehyde for 15 min at RT. Samples were incubated with Kir6.1 monoclonal antibody (Product # MA5-45741) at 1:100 for 60 min at RT, followed by Goat Anti-Mouse ATTO 488 at 1:100 for 60 min at RT. Counterstain used was Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1,000, 1:5,000 for 6... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-45741
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
N366/60
Immunogen
Fusion protein amino acids 306-424 (Cytoplasmic C-terminus) of rat Kir6.1
Conjugate
APC
APC
APC
Excitation/Emission Max
651/660 nm
View spectra
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
95.46mM phosphate/2.48mM MES, pH 7.4, with 2mM EDTA
Contains
no preservative
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
A 1:100 dilution of MA5-45741 was sufficient for detection of Kir6.1 in 20 µg of mouse brain lysate by ECL immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. |Detects approximately 45kDa.
This antibody was formerly sold as clone S366-60.
Target Information
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. KCNJ8 is an integral membrane protein and inward-rectifier type potassium channel. KCNJ8, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins.Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: inward rectifier K(+) channel Kir6.1; inwardly rectifier K(+) channel Kir6.1; Inwardly rectifying potassium channel gene, subfamily J-8 (ATP sensitive); inwardly rectifying potassium channel KIR6.1; potassium channel, inwardly rectifying subfamily J member 8; potassium voltage-gated channel subfamily J member 8; unnamed protein product
Gene Aliases: gnite; KIR6.1; slmbr; sltr; uKATP-1; UKATP1
UniProt ID: (Human) Q15842, (Mouse) P97794, (Rat) Q63664
Entrez Gene ID: (Human) 3764, (Mouse) 16523, (Rat) 25472
inward rectifier potassium channel activity
protein binding
ATP binding
ATP-activated inward rectifier potassium channel activity
sulfonylurea receptor binding
cation-transporting ATPase activity
voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
kidney development
potassium ion transport
transmembrane transport
potassium ion transmembrane transport
inorganic cation import across plasma membrane
membrane repolarization during ventricular cardiac muscle cell action potential
regulation of presynaptic membrane potential
transport across blood-brain barrier
potassium ion import across plasma membrane
action potential
blood vessel development
response to hypoxia
microglial cell activation
vasculature development
regulation of heart rate
adaptive immune response
response to ischemia
heart morphogenesis
ventricular cardiac muscle tissue development
apoptotic process
response to stress
inflammatory response
heart development
regulation of blood pressure
cell proliferation
determination of adult lifespan
protein secretion
response to xenobiotic stimulus
phloem or xylem histogenesis
gene expression
fatty acid transport
transmission of nerve impulse
establishment of cell polarity
response to lipopolysaccharide
response to insulin
response to ATP
response to cytokine
response to endoplasmic reticulum stress
p38MAPK cascade
vasodilation
response to exogenous dsRNA
NLRP3 inflammasome complex assembly
fat cell differentiation
fibroblast proliferation
neurological system process
neuromuscular process
synaptic growth at neuromuscular junction
neuron apoptotic process
defense response to virus
cardiac pacemaker cell differentiation
atrioventricular node cell differentiation
coronary vasculature development
glutamate secretion, neurotransmission
CAMKK-AMPK signaling cascade
calcium ion transmembrane transport
circulatory system development
reactive gliosis
response to resveratrol
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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