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Invitrogen
Kir6.1 (KCNJ8) Monoclonal Antibody (N366/60), PerCP
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FIGURE: 1 / 3
Kir6.1 (KCNJ8) Antibody (MA5-45743) in ICC/IF
Immunocytochemistry/Immunofluorescence analysis using human neuroblastoma cells. Fixation involved 4% Formaldehyde for 15 min at RT. Samples were incubated with Kir6.1 monoclonal antibody (Product # MA5-45743) at 1:100 for 60 min at RT, followed by Goat Anti-Mouse ATTO 488 at 1:100 for 60 min at RT. Counterstain used was Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1,000, 1:5,000 for 6... View More
Product Details
MA5-45743
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
N366/60
Immunogen
Fusion protein amino acids 306-424 (Cytoplasmic C-terminus) of rat Kir6.1
Conjugate
Excitation/Emission Max
482/675 nm
View spectra
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
95.64mM phosphate/2.48mM MES, pH 7.4, with 0.5M EDTA
Contains
no preservative
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
A 1:100 dilution of MA5-45743 was sufficient for detection of Kir6.1 in 20 µg of mouse brain lysate by ECL immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. |Detects approximately 45kDa.
This antibody was formerly sold as clone S366-60.
Target Information
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. KCNJ8 is an integral membrane protein and inward-rectifier type potassium channel. KCNJ8, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins.Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATP-sensitive inward rectifier potassium channel 8; Inward rectifier K(+) channel Kir6.1; inwardly rectifier K(+) channel Kir6.1; Inwardly rectifying potassium channel gene subfamily J-8 (ATP sensitive); Inwardly rectifying potassium channel gene, subfamily J-8 (ATP sensitive); inwardly rectifying potassium channel KIR6.1; Potassium channel, inwardly rectifying subfamily J member 8; potassium inwardly-rectifying channel, subfamily J, member 8; potassium voltage-gated channel subfamily J member 8; uKATP-1; unnamed protein product
Gene Aliases: AI448900; gnite; KCNJ8; KIR6.1; slmbr; sltr; uKATP-1; UKATP1
UniProt ID: (Human) Q15842, (Mouse) P97794, (Rat) Q63664
Entrez Gene ID: (Human) 3764, (Mouse) 16523, (Rat) 25472
inward rectifier potassium channel activity
protein binding
ATP binding
ATP-activated inward rectifier potassium channel activity
sulfonylurea receptor binding
cation-transporting ATPase activity
voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
voltage-gated ion channel activity
G-protein activated inward rectifier potassium channel activity
ion channel
transporter
action potential
blood vessel development
response to hypoxia
microglial cell activation
kidney development
vasculature development
regulation of heart rate
adaptive immune response
response to ischemia
heart morphogenesis
ventricular cardiac muscle tissue development
ion transport
potassium ion transport
apoptotic process
response to stress
inflammatory response
heart development
regulation of blood pressure
cell proliferation
determination of adult lifespan
protein secretion
response to xenobiotic stimulus
gene expression
fatty acid transport
transmission of nerve impulse
establishment of cell polarity
response to lipopolysaccharide
response to insulin
response to ATP
response to cytokine
ion transmembrane transport
regulation of ion transmembrane transport
response to endoplasmic reticulum stress
p38MAPK cascade
vasodilation
response to exogenous dsRNA
NLRP3 inflammasome complex assembly
fat cell differentiation
fibroblast proliferation
neurological system process
neuromuscular process
synaptic growth at neuromuscular junction
defense response to virus
cardiac pacemaker cell differentiation
atrioventricular node cell differentiation
coronary vasculature development
glutamate secretion, neurotransmission
CAMKK-AMPK signaling cascade
calcium ion transmembrane transport
potassium ion transmembrane transport
circulatory system development
inorganic cation transmembrane transport
membrane repolarization during ventricular cardiac muscle cell action potential
regulation of presynaptic membrane potential
reactive gliosis
transport across blood-brain barrier
response to resveratrol
potassium ion import across plasma membrane
transport
response to pH
potassium ion import
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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