HyPerforma Single-Use Mixer

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Efficient and powerful mixing

The Thermo Scientific HyPerforma Single-Use Mixer (S.U.M.) was designed using a proven engineered mixer platform design and offers an ergonomic and efficient user experience for upstream and downstream mixing applications. The complete line of HyPerforma S.U.M.s includes 50, 100, 200, 500, 1,000, and 2,000 L sizes to support consistent scalability in a number of application usages from powder media and buffer hydration to advanced downstream harvest and intermediate pooling steps.

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Features and system highlights

System highlights

  • Touchscreen Console—enhanced user interface provides monitoring and control of the mixing parameters
  • Unique proprietary mixing system offers conventional overhead mixing while maintaining sterility and integrity of the S.U.B. BPC
  • Mixer vessel available with non-jacketed (no heat transfer) or water jacket (vessel side and bottom) for integration with external temperature control unit
  • Single-use contact surfaces for mixing, venting, and temperature sensing
  • Conical vessel bottom for better drainage and less hold-up volume
  • Open cart frame for easier cleaning
  • Load cells weighing systems enable accurate batch weight monitoring

Key features

  • Adjustable powder hanger that fits 1 kg, 5 kg, and 25 kg Powdertainer BPCs
  • Cable management system designed for organization of electrical cables, tubing, and line sets while making the unit easy to clean
  • Dedicated adjustable tool holder keeps necessary tools available for convenience
  • The Touchscreen Console for HyPerforma S.U.M. offers superior integrated sensor monitoring, automated mixing recipes, and pump control for pH and saline titration and for automatic fill and harvest of the S.U.M.

Areas of application

Critical upstream application steps

Critical downstream application steps
  • Media preparation
  • Final formulation steps
  • Buffer preparation
  • Harvest vessels
  • Large-volume mixing (up to 2,000 L)
  • Pooling and liquid transfer
  • Product suspension
  • Mixing and storing multiple batches
  • Buffer preparation
  • Viral inactivation
  • Acid/base titration

Help minimize risk with Thermo Scientific BioProcess Containers (BPCs) featuring the BioTitan Retention Device

Thermo Scientific BPCs are available for the HyPerforma S.U.M. in standard or customized configurations, with your choice of Thermo Scientific CX5-14 or Aegis 5-14 film. Thermo Scientific films have among the cleanest particulate profiles in the industry and are trusted for their robustness, flexibility, and mechanical properties.

S.U.M. BPC options include:
  • Open top liner for media/buffer hydration
  • Closed BPC with powder port for contained media/buffer hydration
  • Closed BPC with powder port and monitoring probe capability
  • Closed BPC for liquid-liquid mixing of critical sterile solutions, such as pooling of fractions or processing of intermediate solutions
  • Closed BPC for liquid-liquid mixing with monitoring probe capability
  • BioTitan Retention Device—an innovative replacement to traditional cable ties, providing a 360-degree seal, available for use on all HyPerforma single-use mixers

HyPerforma Mixer Touchscreen Console

In bioprocessing, mixing technologies can be found completing vital tasks across the entire workflow, and thus mixing equipment should be selected to best meet the demands of an increasingly complex industry. The Touchscreen Console can enhance your upstream and downstream processes by offering advanced sensor monitoring and user-defined automated mixing recipes. The Touchscreen Console is designed to improve yields, shorten process times, and optimize workflows.

Key advantages
 

Customized module user interface allows for superior process monitoring and automation. Modules include:

  • Agitation (mixing rpm)
  • Mass (utilization of load cell readings)
  • Temperature (1 or 2 RTDs)
  • Timer
  • pH (1 or 2 readings)
  • Conductivity (1 or 2 readings)
  • BPC pressure (automated BPC air fill)
  • Liquid pressure (pump control based on liquid pressure in lineset)
  • Pump control (up to four pumps, used for fill, harvest, and bolus control)
  • Automated and metered
  • Fill and harvest
  • Recipes (user defined process automation)
  • Auxiliary input

 

The HyPerforma S.U.M. with Touchscreen Console may be fully integrated with either Thermo Scientific HyPerforma G3 Bioprocess Controllers or controllers from other manufacturers, supporting an open-architecture mixing solution configured to your unique requirements.

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Single-Use Bioprocessing Equipment and Automation

We are committed to delivering exceptional performance, reliability, and quality.
 

Single-Use Bioprocessing

Our innovative single-use technologies enable you to accelerate biological manufacturing processes to create flexibility and operate more dynamically within upstream and downstream workflows.

BioProcessing Containers and Nalgene Bottles

We offer high-quality storage, transport, and sampling solutions, including Thermo Scientific BioProcess Containers (BPCs) and Thermo Scientific Nalgene containers.
 

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Additional bioprocessing resources

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For research use or further manufacturing. Not for diagnostic use or direct administration into humans or animals.