SUM_Main_Final-showcase

The Thermo Scientific HyPerforma Single-Use Mixer (S.U.M.) has been designed using a proven engineered mixer platform design and offers a more ergonomic and efficient user experience for upstream and downstream mixing applications. The complete line of HyPerforma S.U.M.s includes 50, 100, 200, 500, 1,000 and 2,000 L sizes that helps ensure consistent scalability while providing a number of application usages from powder media and buffer hydration to advanced downstream harvest and intermediate pooling steps.

The Touchscreen Console for HyPerforma S.U.M. provides superior integrated sensor monitoring, automated mixing recipes, and pump control for pH and saline titration and for automatic fill and harvest of the S.U.M.

In bioproduction, mixing technologies can be found completing vital tasks across the entire workflow, and thus mixing equipment should be selected to best meet the demands of an increasingly complex industry. Enhance your upstream and downstream processes with the Touchscreen Console for S.U.M. The Touchscreen Console provides the user with advanced sensor monitoring and user-defined automated mixing recipes. The Touchscreen Console will help improve yields, shorten process times, and optimize workflows.

Key advantages
Customized module user interface allows for superior process monitoring and automation. Modules include:

areas-of=review
  • Agitation (mixing rpm)
  • Mass (utilization of load cell readings)
  • Temperature (1 or 2 RTDs)
  • Timer
  • pH (1 or 2 readings)
  • Conductivity (1 or 2 readings)
  • BPC pressure (automated BPC air fill)
  • Liquid pressure (Pump control based on liquid pressure in lineset)
  • Pump control (up to four pumps, used for fill, harvest, and bolus control
  • Automated and metered
  • Fill and harvest
  • Recipes (user defined process automation)
  • Auxiliary input

As an engineering to order product, the HyPerforma S.U.M. with touchscreen console may be fully integrated with either Thermo Scientific HyPerforma G3 Bioprocess Controllers, or controllers from other manufacturers, providing an open-architecture mixing solution configured to your unique requirements.

The touchscreen console has the capability to integrate Thermo Scientific TruBio automation software powered by Emerson’s DeltaV Distributed Control platform, enables users to optimize data acquisition, while maintaining full compliance with 21 CFR Part 11.

System highlights

  • Touchscreen Console – Enhanced user interface provides monitoring and control of the mixing parameters
  • Unique proprietary mixing system that provides conventional overhead mixing while maintaining sterility and integrity of the S.U.B. BPC
  • Mixer vessel offered with non-jacketed (no heat transfer) or water jacket (vessel side and bottom) for integration with external temperature control unit
  • Single-use contact surfaces for mixing, venting, and temperature sensing
  • Conical vessel bottom for better drainage and less hold-up volume
  • Open cart frame for easier cleaning
  • Load cells weighing systems enable accurate batch weight monitoring

Key features

  • Adjustable powder hanger that fits 1 kg, 5 kg, 25 kg Powdertainer BPCs
  • Cable management system provides greater organization for electrical cables, tubing and line sets while making the unit easier to clean
  • Dedicated adjustable tool holder keeps necessary tools available for convenience
areas-application

Critical upstream application steps:

  • Media preparation
  • Final formulation steps
  • Buffer preparation
  • Harvest vessels
  • Large-volume mixing (up to 2,000 L)

Critical downstream application steps:

  • Pooling and liquid transfer
  • Product suspension
  • Mixing and storing multiple batches
  • Buffer preparation
  • Viral inactivation
  • Acid/base titration

In bioproduction, mixing technologies can be found completing vital tasks across the entire workflow, and thus mixing equipment should be selected to best meet the demands of an increasingly complex industry. Enhance your upstream and downstream processes with the Touchscreen Console for S.U.M. The Touchscreen Console provides the user with advanced sensor monitoring and user-defined automated mixing recipes. The Touchscreen Console will help improve yields, shorten process times, and optimize workflows.

Key advantages
Customized module user interface allows for superior process monitoring and automation. Modules include:

areas-of=review
  • Agitation (mixing rpm)
  • Mass (utilization of load cell readings)
  • Temperature (1 or 2 RTDs)
  • Timer
  • pH (1 or 2 readings)
  • Conductivity (1 or 2 readings)
  • BPC pressure (automated BPC air fill)
  • Liquid pressure (Pump control based on liquid pressure in lineset)
  • Pump control (up to four pumps, used for fill, harvest, and bolus control
  • Automated and metered
  • Fill and harvest
  • Recipes (user defined process automation)
  • Auxiliary input

As an engineering to order product, the HyPerforma S.U.M. with touchscreen console may be fully integrated with either Thermo Scientific HyPerforma G3 Bioprocess Controllers, or controllers from other manufacturers, providing an open-architecture mixing solution configured to your unique requirements.

The touchscreen console has the capability to integrate Thermo Scientific TruBio automation software powered by Emerson’s DeltaV Distributed Control platform, enables users to optimize data acquisition, while maintaining full compliance with 21 CFR Part 11.

System highlights

  • Touchscreen Console – Enhanced user interface provides monitoring and control of the mixing parameters
  • Unique proprietary mixing system that provides conventional overhead mixing while maintaining sterility and integrity of the S.U.B. BPC
  • Mixer vessel offered with non-jacketed (no heat transfer) or water jacket (vessel side and bottom) for integration with external temperature control unit
  • Single-use contact surfaces for mixing, venting, and temperature sensing
  • Conical vessel bottom for better drainage and less hold-up volume
  • Open cart frame for easier cleaning
  • Load cells weighing systems enable accurate batch weight monitoring

Key features

  • Adjustable powder hanger that fits 1 kg, 5 kg, 25 kg Powdertainer BPCs
  • Cable management system provides greater organization for electrical cables, tubing and line sets while making the unit easier to clean
  • Dedicated adjustable tool holder keeps necessary tools available for convenience
areas-application

Critical upstream application steps:

  • Media preparation
  • Final formulation steps
  • Buffer preparation
  • Harvest vessels
  • Large-volume mixing (up to 2,000 L)

Critical downstream application steps:

  • Pooling and liquid transfer
  • Product suspension
  • Mixing and storing multiple batches
  • Buffer preparation
  • Viral inactivation
  • Acid/base titration
Solutions utilizing the HyPerforma S.U.M. with Touchscreen Console

Related products

TruBio Automation Software

Thermo Scientific TruBio, TruChrom, and TruPur automation software platforms are capable of controlling bioreactor systems from research to commercial manufacturing.

HyPerforma Bioprocess Controllers

Thermo Scientific HyPerforma G3 Bioprocess Controllers provide ease of data transferability and scalability throughout your process and incorporates innovative features that enhance productivity, quality, and reproducibility.

Ordering information

Bioprocessing resources

Access a targeted collection of scientific application notes, case studies, posters, white papers and more for bioprocessing: