As scientists obtain and analyze genomic sequence information, more and more genetic variants are identified. As the field moves toward trying to understand the significance and potential utility of these variants, the need for rapid, reliable methods of detection has emerged.

Thermo Fisher offers real-time PCR products and other tools specifically for genotyping and genetic variation research, from isolating and purifying genomic DNA, selecting probe and primers, DNA amplification, performing allelic discrimination, and analyzing data.

Ideal for studying a small number of SNPs across fewer than 1,000 samples.

Ideal for studying a low to medium number of SNPs across more than 1,000 samples.

Accurate target quantitation for copy number analysis of specific targets.

Detect and quantitate very small amounts of mutant DNA in a background of wild type DNA using competitive allele-specific PCR (castPCR).

Detect genetic polymorphisms in known high-value DME pharmacogenetics markers, including the PharmaADME core markers.

High Resolution Melting (HRM) analysis is a post-PCR analysis method used to identify variations in nucleic acid sequences.  Thermo Fisher offers two HRM applications: methylation analysis and mutation scanning.

Resources

 TaqMan Assays for genetic variation research