Orbitrap Excedion Pro Mass Spectrometer

Electron Transfer Dissociation (EASY-ETD) option combined with HCD (Higher-Energy Collisional Dissociation) fragmentation delivers unique EThcD (Electron-Transfer/Higher-Energy Collisional Dissociation) fragmentation data on a hybrid benchtop mass spectrometer.

For increased ion flux and gentle transfer of ions for lower limits of detection for a wider range of molecules, the high-sensitivity atmospheric pressure interface combines high-capacity ion transfer tube and electrodynamic ion funnel, optimized for labile compounds and efficient ion transfer.

MS/MS acquisition rates of up to 70 Hz in the Orbitrap mass analyzer with maximum resolution of 480,000 (FWHM) at m/z 200.

Enhanced dynamic range (eDR) mode enables five orders of magnitude intrascan dynamic range.

Hybrid-DIA combines the sensitivity and specificity of targeted experiments with the unbiased discovery of DIA-based shotgun proteomics in a single experiment.

Unique processing mode powered by Phased Spectrum Deconvolution Method (ΦSDM) improves the acquisition rate of TMTpro 32plex reagents experiments.

Adaptive RT for dynamic adjustment of chromatographic monitoring windows ensures reproducible measurements with sensitivity and specificity for comprehensive coverage of targeted compounds across large sample cohorts.

Ultra-high-field Orbitrap mass analyzer with scan speed up to 70 Hz — Scan speed indicates the speed that the instrument acquires MS2 mass spectra per second.

Enhanced dynamic range (eDR) — Full MS mass range is dissected into two Orbitrap subscans, each performing multiplexed isolation and overall MS1 acquisition of equidistant or customizable m/z sub-ranges with efficient ion delivery to the Orbitrap analyzer. Stitching of two Orbitrap subscans is achieved automatically and fully embedded in the data structure. The number of windows within each Orbitrap subscan can be adjusted according to individual needs.

TurboTMT intelligent data acquisition mode (TMTpro 32plex) — Unique processing mode powered by Phased Spectrum Deconvolution Method (ΦSDM) specifically designed to improve the acquisition rate of Thermo Scientific TMTpro 32plex reagents experiments.

Hybrid-DIA — Combines the sensitivity and specificity of targeted proteomics experiments with the unbiased discovery of DIA-based shotgun proteomics in a single experiment.

Enhanced stability — The new heater and sprayer design significantly enhances heat transfer, ensuring exceptional electrospray stability across a broad temperature range.

User-friendly design — Experience enhanced ease of use with adjustable and reproducible movement to simplify your workflow.

Versatile flow rate compatibility — Supports a wide range of flow rates from 1 - 2,000 µL/min, providing flexibility for various applications.

Optimized for labile compounds — Radio frequency (RF) device optimized for labile compounds efficiently capture ions as they leave the High-Capacity Transfer Tube (HCTT). Automatic tuning results in broad ion transmission curves with reduced ion losses, increasing sensitivity.

Fast and sensitive alternative fragmentation Electron Transfer Dissociation (ETD) generated from fluoranthene radical anions. The townsend discharge provides extremely stable and robust ionization. Compact size, located entirely within the footprint of the instrument.

ETD and EThcD fragmentation occur in the ion routing multipole followed by detection in the Orbitrap mass analyzer. The EThcD combination provides b- and y-type and c- and z-type fragment ions in a single Orbitrap spectrum.

Reduces noise by preventing neutrals and high-velocity clusters from entering the quadrupole mass filter using a double bent design geometry. Axial field along the length of the rods improves ion transfer robustness. To increase duty cycles up to 150%, a pre-accumulation of ions can be modulated with Automatic Gain Control (AGC).

To reduce carbon footprint and overall maintenance, Orbitrap Excedion Pro Mass Spectrometers come standard with a single rough dry pump instead of two oil pumps.

• 30% less energy consumption
• Reduced noise and heat production

Software solutions across all next-generation Thermo Scientific platforms for ease of use through different systems. Get meaningful results faster with edition-specific application templates that are ready to use and built into the method editor.

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