Orbitrap Excedion Pro BioPharma Edition Mass Spectrometer

Electron Transfer Dissociation (EASY-ETD) option combined with HCD (Higher-Energy Collisional Dissociation) fragmentation delivers unique EThcD (Electron-Transfer/Higher-Energy Collisional Dissociation) fragmentation data on a hybrid benchtop mass spectrometer.

For increased ion flux and gentle transfer of ions for lower limits of detection for a wider range of molecules, the high-sensitivity atmospheric pressure interface combines high-capacity ion transfer tube and electrodynamic ion funnel, optimized for labile compounds and efficient ion transfer.

MS/MS acquisition rates of up to 70 Hz in the Orbitrap mass analyzer with maximum resolution of 480,000 (FWHM) at m/z 200.

Enhanced dynamic range (eDR) mode enables five orders of magnitude intrascan dynamic range under defined conditions.

Extended mass range up to m/z 12,000 with application mode “Intact Protein”.

Adaptive RT for dynamic adjustment of chromatographic monitoring windows ensures reproducible measurements with sensitivity and specificity.

Ultra-high-field Orbitrap mass analyzer with scan speed up to 70 Hz — Scan speed indicates the speed that the instrument acquires MS2 mass spectra per second.

Extended mass range up to m/z 12,000 (unique to BioPharma Edition) — for characterization of intact proteins under native and denatured conditions.

Enhanced dynamic range (eDR) — Full MS mass range is dissected into two Orbitrap subscans, each performing multiplexed isolation and overall MS1 acquisition of equidistant or customizable m/z sub-ranges with efficient ion delivery to the Orbitrap analyzer. Stitching of two Orbitrap subscans is achieved automatically and fully embedded in the data structure. The number of windows within each Orbitrap subscan can be adjusted according to individual needs.

TurboTMT intelligent data acquisition mode (TMTpro 32plex) — Unique processing mode powered by Phased Spectrum Deconvolution Method (ΦSDM) specifically designed to improve the acquisition rate of Thermo Scientific TMTpro 32plex reagents experiments.

Enhanced stability — The new heater and sprayer design significantly enhances heat transfer, ensuring superior electrospray stability across a broad temperature range.

User-friendly design — Experience enhanced ease of use with adjustable and reproducible movement to simplify your workflow.

Versatile flow rate compatibility — Supports a wide range of flow rates from 1 - 2,000 µL/min, providing flexibility for various applications.

Radio frequency (RF) device, optimized for labile compounds, efficiently captures ions as they leave the High-Capacity Transfer Tube (HCTT). Automatic tuning results in broad ion transmission curves with reduced ion losses and increased sensitivity.

Fast and sensitive alternative fragmentation Electron Transfer Dissociation (ETD) generated from fluoranthene radical anions. The townsend discharge provides extremely stable and robust ionization. The EASY-ETD option is compact and contained entirely within the footprint of the instrument.

With application mode ‘Intact Protein’ (unique to BioPharma Edition), the pressure regimes inside the Ion-Routing Multipole (low, standard and high) can be selected for best performance with native and denaturing conditions.

ETD and EThcD fragmentation occur in the ion routing multipole followed by detection in the Orbitrap mass analyzer.

The EThcD combination provides b- and y-type and c- and z-type fragment ions in a single Orbitrap spectrum.

Reduces noise by preventing neutrals and high-velocity clusters from entering the quadrupole mass filter using a double bent design geometry. Axial field along the length of the rods improves ion transfer robustness. To increase duty cycles up to 150% a pre-accumulation of ions can be modulated with Automatic Gain Control (AGC).

To reduce carbon footprint and overall maintenance, Orbitrap Excedion Pro Mass Spectrometers come standard with a single rough dry pump instead of two oil pumps.

• 30% less energy consumption
• Reduced noise and heat production

Software solutions across all next-generation Thermo Scientific platforms for ease of use through different systems. Get meaningful results faster with edition-specific application templates that are ready to use and built into the method editor.

Unity Lab Services provides world-class service solutions to support your instruments. Our comprehensive service portfolio was designed to meet the needs of your lab.

• Instrument service plans
• On-demand services
  • Compliance services
  • Preventive maintenance
  • Installation
• Education

Managing services for your instrument has never been easier. Services Central is a centralized online platform that enables you and your colleagues to request service, view service request status and service history, check service plan or warranty coverage, access manuals, and more.