Optimized for biopharmaceutical excellence

The Thermo Scientific Orbitrap Excedion Pro BioPharma Hybrid Mass Spectrometer addresses the unique challenges of biopharmaceutical research. With enhanced precision, sensitivity, and dynamic range, this advanced instrument excels in the analysis of biotherapeutics/biopharmaceuticals from peptides to advanced bispecifics and everything in between.

 

Unlock new potential in your biopharmaceutical applications. With cutting-edge technology and innovative features that ensure accurate and reliable results, Orbitrap Excedion Pro BioPharma MS empowers researchers to push the boundaries of biopharmaceutical science.


Higher sensitivity with alternative fragmentation and new capabilities

Fast and sensitive alternative fragmentation

Electron Transfer Dissociation (EASY-ETD) option combined with HCD (Higher-Energy Collisional Dissociation) fragmentation delivers unique EThcD (Electron-Transfer/Higher-Energy Collisional Dissociation) fragmentation data on a hybrid benchtop mass spectrometer.

Lower limits of detection for a wider range of molecules

For increased ion flux and gentle transfer of ions for lower limits of detection for a wider range of molecules, the high-sensitivity atmospheric pressure interface combines high-capacity ion transfer tube and electrodynamic ion funnel, optimized for labile compounds and efficient ion transfer.

Superior acquisition rate and resolution

MS/MS acquisition rates of up to 70 Hz in the Orbitrap mass analyzer with maximum resolution of 480,000 (FWHM) at m/z 200.

Enhanced intra scan dynamic range

Enhanced dynamic range (eDR) mode enables five orders of magnitude intrascan dynamic range under defined conditions.

Enhanced performance for larger molecules

Extended mass range up to m/z 12,000 with application mode “Intact Protein”.

Comprehensive coverage of targeted compounds

Adaptive RT for dynamic adjustment of chromatographic monitoring windows ensures reproducible measurements with sensitivity and specificity.


Features of Orbitrap Excedion Pro BioPharma Mass Spectrometer

With the Orbitrap Excedion Pro BioPharma Mass Spectrometer, you don't just meet your goals; you exceed them! Embrace the future of mass spectrometry and unlock new possibilities in your research and development endeavors. Discover the power of innovation and exceed your expectations with the Orbitrap Excedion Pro BioPharma MS.

Orbitrap technology

Ultra-high-field Orbitrap mass analyzer with scan speed up to 70 Hz — Scan speed indicates the speed that the instrument acquires MS2 mass spectra per second.

 

Extended mass range up to m/z 12,000 (unique to BioPharma Edition) — for characterization of intact proteins under native and denatured conditions.

 

Enhanced dynamic range (eDR) — Full MS mass range is dissected into two Orbitrap subscans, each performing multiplexed isolation and overall MS1 acquisition of equidistant or customizable m/z sub-ranges with efficient ion delivery to the Orbitrap analyzer. Stitching of two Orbitrap subscans is achieved automatically and fully embedded in the data structure. The number of windows within each Orbitrap subscan can be adjusted according to individual needs.

 

TurboTMT intelligent data acquisition mode (TMTpro 32plex) — Unique processing mode powered by Phased Spectrum Deconvolution Method (ΦSDM) specifically designed to improve the acquisition rate of Thermo Scientific TMTpro 32plex reagents experiments.

Thermo Scientific OptaMax Plus Ion Source

Enhanced stability — The new heater and sprayer design significantly enhances heat transfer, ensuring superior electrospray stability across a broad temperature range.

 

User-friendly design — Experience enhanced ease of use with adjustable and reproducible movement to simplify your workflow.

 

Versatile flow rate compatibility — Supports a wide range of flow rates from 1 - 2,000 µL/min, providing flexibility for various applications.

Electrodynamic ion funnel (EDIF)

Radio frequency (RF) device, optimized for labile compounds, efficiently captures ions as they leave the High-Capacity Transfer Tube (HCTT). Automatic tuning results in broad ion transmission curves with reduced ion losses and increased sensitivity.

EASY-ETD option

Fast and sensitive alternative fragmentation Electron Transfer Dissociation (ETD) generated from fluoranthene radical anions. The townsend discharge provides extremely stable and robust ionization. The EASY-ETD option is compact and contained entirely within the footprint of the instrument.

Intact Protein mode and fast and sensitive alternative fragmentation

With application mode ‘Intact Protein’ (unique to BioPharma Edition), the pressure regimes inside the Ion-Routing Multipole (low, standard and high) can be selected for best performance with native and denaturing conditions.

 

ETD and EThcD fragmentation occur in the ion routing multipole followed by detection in the Orbitrap mass analyzer.

 

The EThcD combination provides b- and y-type and c- and z-type fragment ions in a single Orbitrap spectrum.

Bent trap

Reduces noise by preventing neutrals and high-velocity clusters from entering the quadrupole mass filter using a double bent design geometry. Axial field along the length of the rods improves ion transfer robustness. To increase duty cycles up to 150% a pre-accumulation of ions can be modulated with Automatic Gain Control (AGC).

Improve sustainability with less maintenance

To reduce carbon footprint and overall maintenance, Orbitrap Excedion Pro Mass Spectrometers come standard with a single rough dry pump instead of two oil pumps.

  • 30% less energy consumption
  • Reduced noise and heat production

Streamlined instrument control software

Software solutions across all next-generation Thermo Scientific platforms for ease of use through different systems. Get meaningful results faster with edition-specific application templates that are ready to use and built into the method editor.


Resources

Discover how you can unlock the full potential of your research with innovative features and capabilities.

Review precise specifications to determine the Orbitrap Excedion Pro BioPharma Mass Spectrometer that meets your needs.


Service and support

Unity Lab Services provides world-class service solutions to support your instruments. Our comprehensive service portfolio was designed to meet the needs of your lab.

  • Instrument service plans
  • On-demand services
    • Compliance services
    • Preventive maintenance
    • Installation
  • Education

 

Managing services for your instrument has never been easier. Services Central is a centralized online platform that enables you and your colleagues to request service, view service request status and service history, check service plan or warranty coverage, access manuals, and more.


For Research Use Only. Not for use in diagnostic procedures.