Vanquish HPLC and UHPLC Systems

Thermo Scientific Vanquish HPLC & UHPLC Systems

Our base systems support a range of pressures, flow rates, column dimensions, and detector options to meet your application and performance needs.

Description
Vanquish Core HPLC Systems	Vanquish Flex UHPLC Systems	Vanquish Horizon UHPLC Systems	Vanquish Neo UHPLC System
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A dependable workhorse for your high-volume QC analysis	Run HPLC and UHPLC analyses on a single system	Run smaller particles and column dimensions with confidence	Delivers robust separations 24/7 to support your high-sensitivity LC-MS workflows
Pump options
Binary, quaternary, dual & isocratic	Binary, quaternary & dual	Binary	Binary
Maximum system pressure
700 bar	1000 bar	1500 bar	1500 bar
Flow range
0.001–10 mL/min	0.001–8 mL/min	0.001–5 mL/min	1 nL/min–100 μL/min
Column particle size
3–5 µm	1.5–3 µm	< 3 µm	≤ 3 µm
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Application-specific systems

Our application-specific instruments can help you maximize productivity, sample knowledge and purity, or optimize methods.

System feature
Vanquish Duo HPLC & UHPLC Systems	Vanquish Online 2D-LC Systems	Vanquish Analytical Purification LC Systems	Vanquish Method Development System
Run two analyses, simultaneously, on one instrument	Improve analysis of complex samples or simplify separation of poorly resolved analytes	High-performance fractionation capabilities to deliver you ultra-pure products	Accelerate and optimize your method by testing different buffers mixtures across six columns
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Smarter, faster, and greener by design workflows

Featuring a handful of new enhancements with replaceable parts to help increase your return on investment and support your sustainability goals. Our Vanquish LC Systems are now easier to use, more reliable, and include torque-controlled fingertight fittings as standard.

Easier to use

Tool-free torque-controlled fitting technology helps you lock in confident fluidic connections
Full suite of built-in tools to ease method transfer and support cross-lab data consistency
Perform system prep work at instrument with enhanced Vanquish User Interface

Greater ROI

Supports a wide pressure range to accommodate using columns with smaller dimensions
Dual-channel instruments double your throughput without taking up more bench space
Automatic vessel bottom recognition helps you get more from each sample
Optional auto-sampler extension to maximize your daily sample capacity

Greener by design

Platinum ACT 2.0 instrument rating supports eco-conscious labs
Manufactured in facilities fully powered by renewable energy
More sustainable packing for Viper TQ UHPLC Fittings
Replaceable capillaries for column active pre-heaters

What our customers love

I love my Vanquish HPLC so much because its performance is so reliable. During the pandemic, we didn't get a chance to work on it, and it was turned off for over a year. But after we returned to the lab, we did quick routine maintenance and injected some QC samples. The retention times of the standards aligned SO WELL with previous QCs. I was absolutely in awe of the reproducibility. I would definitely recommend Vanquish to my colleagues.
— Harong L. | Academia

My Vanquish UHPLC, named Cynthia, has been a fantastic addition to my lab space. Fast run times, robust methodology, and the ease of use for Chromeleon makes Cynthia a vital part of my lab team!
— Bjorn L. | Industry

We performed a method translation from a dated HPLC method to UHPLC on the Vanquish. The new method allows this test to be performed within one shift instead of across multiple shifts/personnel.
— Nicholas G., | Pharma