Vanquish Core HPLC Systems

Eliminate disruptions to your routine analytical work with the Thermo Scientific Vanquish Core HPLC system. No matter which systems you currently use, switching to Vanquish Core is simple and seamless. A full suite of method transfer tools, including tunable gradient delay volume, makes adoption easy. Like all members of our Vanquish product line, Vanquish Core HPLC systems offer hardware precision, detector sensitivity, and simplicity of operation.

Build your ideal HPLC or UHPLC with our step-by-step configurator


Simplified method transfer

The unique, tunable gradient delay volume (GDV) and multiple thermostatting modes help refine separations to match the originating system. Users can tune the idle volume without replumbing or requalifying the system. 

Experiment with adjusting the GDV to simplify your method transfer in our interactive demo.

Flexible separations

Thermo Scientific SmartFlow pumping technology includes automatic compensation for changes in eluent compressibility to ensure flow and gradient precision, independent of eluent composition and backpressure. The pump can operate up to 700 bar and is available in binary, quaternary, and dual-gradient options. 

Intelligent system tools

Two optional components are available to improve productivity, ensure compliance, and keep laboratories running smoothly. The Thermo Scientific Vanquish Solvent Monitor tracks solvent levels to prevent dry solvent channels and waste spills. Meanwhile, the touchscreen Vanquish User Interface provides visual monitoring of system status.

Versatility in analyte detection

A variety of detection options ensure you can collect the most information from your separation. Our portfolio includes diode array detection, near-universal charged aerosol detection, fluorescence detection, mass spectrometric detection and more. 

Easy and reliable tool-free connections

The Vanquish Core HPLC system is fitted with Thermo Scientific Viper fingertight fittings, which support near-zero dead volume connections and enable sharper peaks and tool-free setup.

CDS software

The Vanquish Core HPLC system integrates with Thermo Scientific Chromeleon Chromatography Data System (CDS) with compliance tools, networking capabilities, automation, and data processing. We offer standard instrument integration (SII) packages to connect Thermo Scientific HPLC systems to other CDS and MS software programs.


System specifications

The table below provides an overview of the Vanquish Core HPLC system specifications for a standard setup. Not all specifications are listed. Your specifications may differ based on the components of your system. Find the specification sheets for the system components in the Component specifications, below.

Category Vanquish Core HPLC Systems
System pressure, maximum 700 bar
Flow range 0–10 mL/min
Pump options (default gradient delay volume)

Binary (400 µL) 

Quaternary (679 µL) 


Delay volume dependent on pump(s) selected

Biocompatible No
pH range 1–13, chloride concentration up to 0.1 mol/L
System design Modular
Touchscreen user interface display compatible (optional) Yes
Solvent monitoring system compatible (optional) Yes
Customizable gradient delay volume to simplify method transfer  Yes, with method transfer kit
SmartInject technology for maximum injection precision and improved column lifetime Yes
Injection volume range

Standard: 0.01-100 µL
Optional: 0.01-1000 µL

Sample cooling

Yes, 4-40°C

Dependent on sampler selected

Sample capacity (standard)
Based on standard 12 mm OD vials (≤ 1.5 mL)

4 racks of 54 vials (≤ 1.5 mL) each, other rack formats available
+ capacity of 12 × 22.5 mm OD vials (≤ 10 mL) in the carousel

Sampler extension available (optional)

Yes, with Vanquish Charger
Column compartment thermostatting Yes, 5-85°C 
Still air and forced air
Column compartment pre-heater

Active (optional) 

Column compartment post-column cooler No
Detector choices

Vanquish Charged Aerosol Detector

Vanquish Diode Array Detector

Vanquish Fluorescence Detector

Vanquish Multiple Wavelength Detector

Vanquish Variable Wavelength Detector

Refractive Index Detector

Mass Spectrometer

Component specifications

Standard Vanquish Core HPLC systems are made up of the following components. Download the associated specifications sheet for more detail on each component.

  Vanquish Core Binary HPLC Vanquish Core Quaternary HPLC Vanquish Core Isocratic HPLC



Download Specification Sheet

Vanquish Binary Pump C Vanquish Quaternary Pump C/CN Vanquish Isocratic Pump C



Download Specification Sheet

Vanquish Split Sampler C/CT

Extended sample capacity (optional)


Download Specification Sheet

Vanquish Charger (optional)

Column compartment


Download Specification Sheet

Vanquish Column Compartment C

Virtually zero dead volume system connections


Download Specification Sheet

Viper UHPLC Fittings Kits



HPLC and UHPLC Detectors page
Optional components: Fraction Collector Visit our Vanquish Fraction Collector FT page

Contact us to get a quote or discuss an HPLC/UHPLC solution

For Research Use Only. Not for use in diagnostic procedures.