Thermo Scientific™

BM(PEG)2 (1,8-bismaleimido-diethyleneglycol)

Catalog number:  22336

 Related applications:

Protein Labeling & Crosslinking

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Thermo Scientific Pierce BM(PEG)2 is a bismaleimide-activated PEG compound for crosslinking between sulfhydryl (—SH) groups in proteins and other thiol molecules. The maleimide groups at either end of the PEG2 spacer react specifically and efficiently with reduced sulfhydryls at pH 6.5-7.5 to form stable thioether bonds.

Features of BM(PEG)2:

Reactive groups: maleimide (both ends)
Reactive towards: sulfhydryl groups
• Long, pegylated, sulfhydryl-to-sulfhydryl crosslinkers, composed of maleimide groups and 2-unit polyethylene glycol spacer arm
• PEG spacers provide unique advantages, including enhanced solubility, increased stability, reduced tendency toward aggregation and reduced immunogenicity
• Pure compounds with defined structure and molecular weight, ensuring reproducible protein-modification effects
• Ideal for small molecule or peptide conjugations

Alternative Names for BM(PEG)n:

• Bismaleimide-dPEG
• Mal-PEG-Mal
• BM(PEO)2

Product References:

Crosslinker Application Guide -- search for recent literature references for this product

Related Products
BMB (1,4-bismaleimidobutane)
BMH (bismaleimidohexane)
BMOE (bismaleimidoethane)
BM(PEG)3 (1,11-bismaleimido-triethyleneglycol)
For Research Use Only. Not for use in diagnostic procedures.


Crosslinker Type: Homobifunctional
Labeling Method: Chemical Labeling
Product Line: Pierce™
Product Size: 50 mg
Solubility: Water
Spacer: Long, Pegylated

Contents & storage

Store desiccated at 4°C. Shipped at ambient temperature.


Manuals & protocols