Thermo Scientific™

SMPH (Succinimidyl 6-((beta-maleimidopropionamido)hexanoate))

Catalog number:  22363

 Related applications:

Protein Labeling & Crosslinking

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Thermo Scientific Pierce SMPH is an amine-to-sulfhydryl crosslinker that contains NHS-ester and maleimide reactive groups at opposite ends of a long spacer arm (14.2 angstroms).

Features of SMPH:

Reactive groups: NHS ester and maleimide
Reactive towards: amino and sulfhydryl groups
• Slightly longer and more soluble than SMPB
• NHS ester reacts with primary amines at pH 7-9, forming a stable amide bond
• Maleimide reacts with -SH groups at pH 6.5-7.5, forming a stable thioether bond
• Non-cleavable
• Water-insoluble (dissolve first in DMF or DMSO)

Product References:
Crosslinker Application Guide -- search for recent literature references for this product

Related Products
SMPH (Succinimidyl 6-((beta-maleimidopropionamido)hexanoate))
For Research Use Only. Not for use in diagnostic procedures.


Crosslinker Type: Heterobifunctional
Labeling Method: Chemical Labeling
Product Line: Pierce™
Product Size: 50 mg
Solubility: DMF (Dimethylformamide), DMSO (Dimethylsulfoxide)
Spacer: Long

Contents & storage

Upon receipt store desiccated at 4°C. Product is shipped at ambient temperature.


Manuals & protocols