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          System Message

          OKCancel
          LOADING ...
          See other SIRT1 SIRNA Assays ›
          Gene Symbol:
          SIRT1
          Gene Name:
          sirtuin 1
          Gene Aliases:
          SIR2, SIR2L1, SIR2alpha
          Chromosome Location:
          Chr.10: 67884669 - 67918390 on Build GRCh38
          UniGene ID:
          Hs.369779
          Species:
          Human
          Species Specific ID (Flybase ID):
          -
          siRNA ID 136458

          Purification
          Size
          Availability Inventoried
          Catalog # AM16708
          Price 4,126.00
          Your Price
          Online offer:
          4126.0
          Check your price ›
          • Genomic Map
          • siRNA Details
          • More Information

          Genomic Map

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          siRNA Details

          Gene Symbol: SIRT1
          Interrogated Sequence Translated Protein Targeted Exon(s) siRNA Location IMAGE Clone ID
          RefSeq NM_012238.4 NP_036370.2 2, 3 597
          GenBank mRNA AF083106.2 - 2, 3 597
          AF235040.1 - 2, 3 592
          AK289743.1 - 2, 3 333
          AL136741.1 - 2, 3 212
          BC012499.1 - 2, 3 177 4518906

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          More Information


          Other Species Targeted

          This siRNA also targets the following transcripts in Rat: XM_006256146.

          Gene Ontology Categories:

          Function(s) Process(es)

          single strand break repair
          negative regulation of transcription from RNA polymerase II promoter
          chromatin silencing at rDNA
          pyrimidine dimer repair by nucleotide-excision repair
          DNA synthesis involved in DNA repair
          angiogenesis
          ovulation from ovarian follicle
          cellular glucose homeostasis
          positive regulation of protein phosphorylation
          positive regulation of endothelial cell proliferation
          positive regulation of adaptive immune response
          DNA replication
          DNA repair
          chromatin organization
          chromatin silencing
          establishment of chromatin silencing
          maintenance of chromatin silencing
          methylation-dependent chromatin silencing
          transcription, DNA-templated
          rRNA processing
          protein ADP-ribosylation
          protein deacetylation
          triglyceride mobilization
          cellular response to DNA damage stimulus
          response to oxidative stress
          spermatogenesis
          regulation of mitotic cell cycle
          muscle organ development
          cell aging
          positive regulation of cell proliferation
          cellular response to starvation
          negative regulation of gene expression
          positive regulation of cholesterol efflux
          regulation of lipid storage
          regulation of glucose metabolic process
          macrophage cytokine production
          positive regulation of phosphatidylinositol 3-kinase signaling
          viral process
          positive regulation of macroautophagy
          protein ubiquitination
          histone deacetylation
          peptidyl-lysine acetylation
          macrophage differentiation
          negative regulation of cell growth
          negative regulation of transforming growth factor beta receptor signaling pathway
          negative regulation of prostaglandin biosynthetic process
          protein destabilization
          positive regulation of chromatin silencing
          negative regulation of TOR signaling
          regulation of endodeoxyribonuclease activity
          negative regulation of NF-kappaB transcription factor activity
          response to insulin
          circadian regulation of gene expression
          regulation of protein import into nucleus, translocation
          leptin-mediated signaling pathway
          regulation of smooth muscle cell apoptotic process
          peptidyl-lysine deacetylation
          cellular triglyceride homeostasis
          regulation of peroxisome proliferator activated receptor signaling pathway
          regulation of cell proliferation
          negative regulation of phosphorylation
          response to hydrogen peroxide
          behavioral response to starvation
          cholesterol homeostasis
          intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
          positive regulation of apoptotic process
          negative regulation of apoptotic process
          negative regulation of I-kappaB kinase/NF-kappaB signaling
          proteasome-mediated ubiquitin-dependent protein catabolic process
          positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
          negative regulation of sequence-specific DNA binding transcription factor activity
          negative regulation of DNA damage response, signal transduction by p53 class mediator
          response to leptin
          positive regulation of MHC class II biosynthetic process
          negative regulation of fat cell differentiation
          positive regulation of DNA repair
          positive regulation of angiogenesis
          negative regulation of transcription, DNA-templated
          positive regulation of transcription from RNA polymerase II promoter
          positive regulation of insulin receptor signaling pathway
          white fat cell differentiation
          negative regulation of helicase activity
          positive regulation of histone H3-K9 methylation
          negative regulation of protein kinase B signaling
          fatty acid homeostasis
          negative regulation of androgen receptor signaling pathway
          histone H3-K9 modification
          cellular response to hydrogen peroxide
          regulation of bile acid biosynthetic process
          UV-damage excision repair
          histone H3 deacetylation
          cellular response to tumor necrosis factor
          negative regulation of histone H3-K14 acetylation
          cellular response to hypoxia
          cellular response to ionizing radiation
          regulation of protein serine/threonine kinase activity
          regulation of brown fat cell differentiation
          stress-induced premature senescence
          regulation of cellular response to heat
          negative regulation of neuron death
          negative regulation of protein acetylation
          negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
          negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
          positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
          positive regulation of adipose tissue development
          histone H3-K9 deacetylation
          positive regulation of macrophage apoptotic process
          negative regulation of cAMP-dependent protein kinase activity
          positive regulation of cAMP-dependent protein kinase activity
          negative regulation of histone H4-K16 acetylation
          negative regulation of cellular response to testosterone stimulus
          negative regulation of peptidyl-lysine acetylation
          negative regulation of cellular senescence
          positive regulation of cellular senescence
          core promoter sequence-specific DNA binding
          p53 binding
          transcription corepressor activity
          NAD+ ADP-ribosyltransferase activity
          histone deacetylase activity
          protein binding
          protein C-terminus binding
          transcription factor binding
          NAD-dependent histone deacetylase activity
          deacetylase activity
          enzyme binding
          protein deacetylase activity
          NAD-dependent protein deacetylase activity
          nuclear hormone receptor binding
          histone binding
          identical protein binding
          HLH domain binding
          bHLH transcription factor binding
          metal ion binding
          NAD-dependent histone deacetylase activity (H3-K9 specific)
          mitogen-activated protein kinase binding
          NAD+ binding
          keratin filament binding

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          Host server : magellan-search-green-55658555d6-pnd5g:80/100.66.79.83:80.
          git-commit: ec8e7df5f8fec8d765bd419205f1b5046a016d37
          git-url: https://github.com/thermofisher/magellan-search
          git-branch: release/2.41.0-Offline