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          System Message

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          LOADING ...
          See other LRRK2 SIRNA Assays ›
          Gene Symbol:
          LRRK2
          Gene Name:
          leucine rich repeat kinase 2
          Gene Aliases:
          AURA17, DARDARIN, PARK8, RIPK7, ROCO2
          Chromosome Location:
          Chr.12: 40224895 - 40369285 on Build GRCh38
          UniGene ID:
          Hs.187636
          Species:
          Human
          Species Specific ID (Flybase ID):
          -
          siRNA ID s536273

          Purification
          Size
          Availability Inventoried
          Catalog # 4392420
          Price
          Your Price
          Online offer:
          Check your price ›
          • Genomic Map
          • siRNA Details
          • More Information

          Genomic Map

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          siRNA Details

          Gene Symbol: LRRK2
          Interrogated Sequence Translated Protein Targeted Exon(s) siRNA Location IMAGE Clone ID
          RefSeq NM_198578.3 NP_940980.3 27 3840
          XM_005268629.3 XP_005268686.1 27 3956
          XM_011537877.2 XP_011536179.1 27 3956
          XM_011537881.2 XP_011536183.1 27 3956
          XM_011537882.2 XP_011536184.1 27 3956
          XM_017018786.1 XP_016874275.1 27 3956
          XM_017018787.1 XP_016874276.1 6 784
          XM_017018789.1 XP_016874278.1 27 3956
          GenBank mRNA AK127729.1 - 18 2570
          AK131537.1 - 2 144
          AL832453.2 - 6 1015
          AY792511.1 - 27 3719
          BC117180.1 - 27 3777 40125731

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          More Information


          Panther Classification:

          Molecular Function -

          scaffold/adaptor protein

          Gene Ontology Categories:

          Function(s) Process(es)

          MAPK cascade
          activation of MAPKK activity
          activation of MAPK activity
          negative regulation of protein phosphorylation
          positive regulation of protein phosphorylation
          protein phosphorylation
          endocytosis
          autophagy
          response to oxidative stress
          mitochondrion organization
          Golgi organization
          lysosome organization
          small GTPase mediated signal transduction
          neuromuscular junction development
          determination of adult lifespan
          cellular response to starvation
          regulation of autophagy
          positive regulation of autophagy
          regulation of protein kinase A signaling
          negative regulation of protein processing
          regulation of neuron maturation
          negative regulation of macroautophagy
          phosphorylation
          peptidyl-serine phosphorylation
          peptidyl-threonine phosphorylation
          calcium-mediated signaling
          olfactory bulb development
          tangential migration from the subventricular zone to the olfactory bulb
          positive regulation of protein ubiquitination
          negative regulation of protein binding
          positive regulation of protein binding
          positive regulation of proteasomal ubiquitin-dependent protein catabolic process
          negative regulation of GTPase activity
          cellular response to oxidative stress
          cellular protein localization
          intracellular signal transduction
          regulation of kidney size
          exploration behavior
          locomotory exploration behavior
          regulation of lysosomal lumen pH
          regulation of locomotion
          regulation of membrane potential
          positive regulation of programmed cell death
          positive regulation of MAP kinase activity
          positive regulation of GTPase activity
          GTP metabolic process
          protein autophosphorylation
          intracellular distribution of mitochondria
          neuron projection morphogenesis
          regulation of calcium-mediated signaling
          mitochondrion localization
          regulation of mitochondrial depolarization
          regulation of synaptic transmission, glutamatergic
          canonical Wnt signaling pathway
          excitatory postsynaptic potential
          regulation of dopamine receptor signaling pathway
          positive regulation of dopamine receptor signaling pathway
          regulation of canonical Wnt signaling pathway
          regulation of dendritic spine morphogenesis
          protein localization to mitochondrion
          neuron death
          cellular response to manganese ion
          reactive oxygen species metabolic process
          regulation of mitochondrial fission
          positive regulation of canonical Wnt signaling pathway
          negative regulation of excitatory postsynaptic potential
          regulation of neuron death
          negative regulation of neuron death
          negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
          positive regulation of protein autoubiquitination
          regulation of neuroblast proliferation
          regulation of synaptic vesicle transport
          negative regulation of late endosome to lysosome transport
          negative regulation of autophagosome assembly
          negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation
          negative regulation of hydrogen peroxide-induced cell death
          negative regulation of protein targeting to mitochondrion
          negative regulation of protein processing involved in protein targeting to mitochondrion
          cellular response to dopamine
          Wnt signalosome assembly
          regulation of retrograde transport, endosome to Golgi
          regulation of branching morphogenesis of a nerve
          regulation of synaptic vesicle exocytosis
          negative regulation of peroxidase activity
          SNARE binding
          glycoprotein binding
          actin binding
          GTPase activity
          protein kinase activity
          protein serine/threonine kinase activity
          MAP kinase kinase activity
          GTPase activator activity
          protein binding
          ATP binding
          GTP binding
          microtubule binding
          tubulin binding
          kinase activity
          Rho GTPase binding
          syntaxin-1 binding
          receptor signaling complex scaffold activity
          clathrin binding
          GTP-dependent protein kinase activity
          peroxidase inhibitor activity
          co-receptor binding
          identical protein binding
          protein homodimerization activity
          ion channel binding
          protein kinase A binding
          beta-catenin destruction complex binding

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