The small-molecule drug discovery process is long, expensive, and risky, with a failure rate estimated at 97%. Our Thermo Scientific Maybridge screening and fragment libraries can shorten this process—and improve its chance of success—by helping to identify or produce high-quality, hit-like, lead-like, and drug-like compounds.
Maybridge screening compounds and libraries have been at the forefront of innovative screening compound design for over 50 years, supporting the needs of drug discovery scientists in their pursuit of novel molecules of pharmaceutical interest.
High-throughput screening (HTS) is an activity-based process that involves testing thousands or even tens of thousands of compounds to identify those that bind to the target. The process is like trying many keys to find one (or more) that fits a lock. When you find a hit, you have learned a great deal and can begin to develop it into a lead.
The Maybridge Screening Collection comprises over 50,000 synthetically derived organic compounds that are structurally and functionally diverse and demonstrate suitable pharmacokinetic properties while excluding potentially problematic structures.
Fragment screening is a structure-based process that has become a method of choice in the quest for rapid identification of new lead molecules in drug discovery. Compared to traditional compound screening, it offers a higher hit probability and fewer fragments that need to be screened. The process is like assembling building blocks into a key that fits into a lock. Finding a hit is easier but does not give you a complete answer.
The Maybridge fragment library, selected from our 30,000 high-quality chemical fragments, is a proven, industry-leading library due to its diversity, pharmacophoric content, and novelty.
Typically, about 95% of the compounds in our collection are available in >5 mg stock quantities, over 90% in >50 mg stock quantities, and a large proportion in gram quantities. This means that we can ensure a very high level of re-supply of originally tested compounds from the exact same stock.
To facilitate screening, selected compounds are available in two pre-plated formats, with stock available for follow-up when required.
|96-well plates||Pre-plated: 1 µmol dry films|
|96-well plates||Upon request: At mass ≥2 µmol or ≥ 0.5 mg as powder, dry films or frozen DMSO solutions|
|384-well plates||Pre-plated: 0.25 µmol dry films|
|384-well plates||Upon request: At mass >0.1 µmol or >0.1 mg as dry films or frozen DMSO solutions|
|Vials||At mass >2 µmol or 0.5 mg as powder or DMSO solutions|
Although our Maybridge compounds team can provide most major brands of plates and vials, we are happy to use those supplied by customers on request.
After identifying a hit, medicinal chemists need to understand why it produced the positive interaction. They typically unravel the pharmacological basis by investigating the structure-activity relationship (SAR) between the molecule and the target, usually by making an additional series of focused compounds, called libraries, to identify a lead. It s an iterative process of making compounds, screening, evaluating the results, making new compounds, and so on. Ultimately the process spins out a refined set of lead molecules that move forward to the next phase.
Hit-to-lead optimization of furosemide. To develop furosemide, a treatment for congestive heart failure and edema, medicinal chemists varied the heterocycle and linker. For each change, they evaluated its effect on drug potency, effectiveness, efficiency, toxicity, and other lead-like properties. Furosemide is commonly marketed by Sanofi-Aventis under the brand name Lasix.
To facilitate this development process, we offer more than 30,000 building blocks within our Thermo Scientific portfolio, including more than 3,000 specially selected heterocyclic compounds (some unique to our collection). These building blocks are designed for medicinal chemists conducting hit-to-lead and lead optimization through SAR development. Most of our building blocks are readily available from stock.
|Contains all key heterocyclic rings||Adds to the pharmacophoric profile of our target molecule|
|Includes major functional groups||Facilitates the full breadth of chemical synthesis techniques|
|Regioisomers||Allows systematical exploration of the structural diversity space and provides intellectual property protection|
|Minimal substitution||Allows easier SAR interpretation|
29th October 2020
In this webinar, Simon Pearce reviews the early-stage drug discovery process and how screening libraries help scientists find the proverbial needle in a haystack. The webinar explains how high-throughput screening (HTS) and fragment-based drug discovery (FBDD) are used to identify hits that can lead to the development of new drugs.
This section includes Thermo Fisher Scientific resources for HTS and fragment screening. For generic chemical resources, consult the Chemical Resource Library.
Product information sheets
For Research Use Only. Not for use in diagnostic procedures.