Transcend LX Multichannel UHPLC Systems

High throughput for clinical LC-MS applications.

Transcend LX Multichannel UHPLC Systems

Improve your LC-MS throughput and get a faster return on investment with a Thermo Scientific Transcend Multichannel LX UHPLC Systems. These UHPLC systems features unique multichannel technology that uses up to four separate LC channels in combination with a single mass spectrometer to increase throughput. Transcend Multichannel LX UHPLC systems offer a new level of simplicity and cost-effectiveness. Thermo Scientific Aria MX software, featuring an intuitive graphical interface, makes method setup easy and schedules all aspects of the system, including scheduling and management for multiple methods on multiple channels, simultaneously.


Increased mass spectrometer utilization

Transcend multichannel systems have two or four LC channels that operate in parallel, independently, into a single mass spectrometer to double or quadruple throughput. One method can be run on all channels or each channel can run a different method simultaneously.

Extended sample capacity

Sample capacity can be extended from six to twelve 96- or 384-well plates by adding another cool stack to the Thermo Scientific TriPlus RSI autosampler for greater throughput. Thermo Scientific Transcend VLX-2 offers increased sample capacity with the Thermo Scientific Vanquish Charger module for a total capacity of up to nearly 9000 samples while the barcode reader simultaneously manages the complete inventory.

Improved throughput

Multichannel technology increases throughput two- to four-fold using a single instrument with no need for new method development, accelerating laboratory output and revenue generation.

Easy setup and system control

Thermo Scientific Aria MX software manages and controls pump operation, valve switching, cleaning, and gradients. Quickly develop methods and run batches of samples while managing multiple LC-MS methods on multiple channels simultaneously. Aria MX software is compatible with Thermo Scientific XCalibur or TraceFinder software.

How does multichannel LC-MS work?

Our multichannel LC system is designed specifically for LC-MS and allows you to run two of the same or two different applications using one mass spectrometer. Two channels run staggered LC-MS analyses, ensuring the mass spectrometer is never idle. The diagram below illustrates the resulting MS signal when running two different applications on the Transcend Multichannel LX UHPLC system simultaneously.

Maximize MS utilization by using multiple channels with intelligent scheduling to run the second analysis during column reconditioning. 

System specifications

The table below provides an overview of the Transcend Multichannel LX UHPLC systems specifications for a standard setup. Not all specifications are listed. Your specifications may differ based on the components of your system. Find the specification sheets for the system components in the Component specifications, below.

Category Transcend (F/H) VLX-2 UHPLC Systems Transcend Multichannel LX-2 and LX-4 UHPLC Systems
System pressure, maximum 1000 (F) or 1500 bar (H) 1000 bar
Flow range 0-8 mL/min (F) or 0-5 mL/min (H) 0-8 mL/min
Pump options (default gradient delay volume)

Binary Pump F (35 µL)
Binary Pump H (100 µL)

Binary (100 µL)
Biocompatible Yes
pH range 2–12, chloride concentration up to 1 mol/L
System design Modular
Touchscreen user interface display compatible (optional) Yes, depends on system configuration No
Solvent monitoring system compatible (optional) No
Customizable gradient delay volume to simplify method transfer Not applicable
SmartInject technology for maximum injection precision and improved column lifetime Yes No
Injection volume range Standard: 0.01-25 µL
Optional: 0.01-100 µL
Standard: 0.01-100 µL
Optional: up to 10,000 µL
Sample cooling Yes

Sample capacity (standard)

Based on standard 12 mm OD vials (≤ 1.5 mL)

4 racks of 54 vials (≤ 1.5mL) each,
other rack formats available +
capacity of 12 x 22.5 mm OD vials (≤ 10 mL)
in the carousel

6 racks that hold 54 vials each
Sampler extension available (optional) Yes, with Vanquish Charger Yes, with drawers
Column compartment thermostatting Yes, 5-120°C
Still air and forced air
Optional sleeve heater

Column compartment pre-heater

Active and passive

Column compartment post-column cooler Yes n.a.
Compatible Detectors

Mass Spectrometer

Component specifications

Standard Transcend Multichannel LX UHPLC systems are made up of the following components. Download the associated specifications sheet for more detail on each component. 

  Transcend LX-2

Transcend LX-4

Transcend VLX-2



Download Specification Sheet

Vanquish Binary Pump F

Vanquish Binary Pump F

2 Vanquish Binary Pump F  or 2 Vanquish Binary Pump H



Triplus RSI Vanquish Dual Split Sampler FT or Vanquish Dual Split Sampler HT

Extended sample capacity (optional)


3- or 6-drawer cool stack 

Vanquish Charger 



Flow path switching


2-valve interface module Vanquish Column Compartment H



One mass spectrometer

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For Research Use Only. Not for use in diagnostic procedures.