Vanquish UHPLC Systems

Separate your science from the status quo

Thermo Scientific Vanquish HPLC and UHPLC systems are the most advanced liquid chromatography instruments available. The Vanquish platform improves performance, repeatability, and dependability with no trade-offs in quality or ease-of-use. Vanquish platform users have all they need to solve their toughest analytical challenges with confidence.

Advanced liquid chromatography systems for solving tough analytical challenges

For any application—whether HPLC or UHPLC, small or large molecules, simple or complex mixtures—the Vanquish platform was designed to handle it all. This innovative, simple-to-operate, and easy-to-maintain platform delivers confident separations that push chromatographic boundaries and continually deliver robust results. Regardless of the configuration you choose, you will get a highly integrated solution with optimal fluidic connections, providing unsurpassed retention time and peak area precision.

You will also benefit from the industry-leading, easy-to-use, and compliant Thermo Scientific Chromeleon Chromatography Data System (CDS) with eWorkflow method setup, dedicated ePanels, Open Access, and smart tools. Chromeleon CDS delivers advanced system communication with single-point intelligent control and functionality. It also provides direct plugins for the Vanquish system to other manufacturers' chromatography data systems.

Choose your Vanquish liquid chromatography systems:

Increase productivity, up-time, and sample knowledge for a faster return on investment. Vanquish Duo HPLC and UHPLC systems expand the benefits of the Vanquish platform through two flow-paths to support four workflows (Dual LC, Tandem LC or LC-MS, Transcend Duo for LX-2, and Inverse Gradient) within one integrated system. With the addition of the second flow-path, your productivity is improved thanks to time savings, lowered cost-per-sample, no added bench space, and without compromise on performance, robustness, or ease-of-use.

Eight reasons to consider Thermo Scientific products for your liquid chromatography needs.

Eight reasons to consider Thermo Scientific products for your liquid chromatography needs - with advanced HPLC solutions that provide superior retention time stability, flexible lab integration with minimal maintenance.

Compare Vanquish HPLC and UHPLC systems

Vanquish Horizon
UHPLC System

Vanquish Flex
UHPLC Systems

Vanquish Core
HPLC Systems

    Unrivaled performance and throughput for applications requiring high-end UHPLC Binary or quaternary solvent blending for fast and reliable UHPLC or flexible method development Remove any disruptions from your routine HPLC analyses


System pressure
Up to 1500 bar

Up to 1000 bar

Up to 700 bar
Retention time precision
Flow range
5 mL/min

8 mL/min

10 mL/min
Design Modular

System components

Pump Vanquish Binary Pump H
The pump with the highest backpressure at 1500 bar, and ideal for any gradient performance from shallow to ballistic
Vanquish Binary Pump F
UHPLC performance for demanding routine applications up to 1000 bar

Vanquish Quaternary Pump F
UHPLC performance with more solvent flexibility up to 1000 bar

Vanquish Binary Pump C
Simplicity and throughput for routine HPLC applications up to 700 bar

Vanquish Quaternary Pump C
Flexibility and dependability for routine HPLC applications up to 700 bar

Vanquish Isocratic Pump C
Simplicity for basic HPLC applications up to 700 bar

Autosampler Vanquish Split Sampler HT
Excellent precision, accuracy, and short cycle times with innovative air-stream cooling and barcode reading for inventory management for all workflows up to 1500 bar
Vanquish Split Sampler FT
Enjoy the same benefits as the Vanquish Split Sampler HT for applications up to 1000 bar
Vanquish Dual Split Sampler C/CT

Delivering extreme dependability and reliability for routine HPLC applications up to 700 bar. Optional thermostatting for samples.
Extended sample capacity Vanquish Charger
An intelligent, robotic rack and plate feeder that automatically loads samples in the autosampler and extends the sample capacity of all Vanquish samplers to up to 8832 samples (23 wellplates or 12 vial racks) with innovative air-stream cooling and barcode reading for inventory management
Column compartment

Vanquish Column Compartment H

Provides two column thermostatting modes (still and forced air), active and passive solvent pre-heating, and post-column cooling for optimized control of your separations and advanced method transfer. Temperature range: 5–120 ˚C

Vanquish Column Compartment C

High performance and flexibility in thermostatting mode to simplify method transfer from any HPLC system. Temperature range: 5–85 ˚C

Virtually zero dead volume system connections Thermo Scientific Viper Fingertight Fittings
Order all the HPLC and UHPLC fittings and capillaries you need for your system or application in a single kit
= Not applicable = Poor = Good = Better = Best


Compatible components for all Vanquish UHPLC systems

Detector options Vanquish columns Chromeleon CDS
Extend pressure capabilities and robustness by using columns that were developed for Vanquish systems, allowing you to separate your science better, faster, and easier than ever before.
All Vanquish systems can be used with any of our HPLC and UHPLC columns
  • Streamlines your data processing
  • Industry-leading ease of use and intelligent functionalities
  • Outstanding data integrity
  • Unique user guidance and hardware automation features designed for Vanquish systems

Discover the best HPLC systems for your applications and budget

Discover the best HPLC system for your applications and budget

Use these tools to help you decide

HPLC Systems Selection Guide
Use this tool to rank the top HPLC instruments for your applications based on your responses to simple pull-down menus.

HPLC System Total Cost of Ownership Calculator
Use this tool to estimate your cost for purchasing and running Thermo Scientific HPLC and UHPLC systems. You can compare costs between instruments.

LC Method Transfer Calculator
Use this online calculator to transfer methods from HPLC to UHPLC conditions. Calculate the new gradient table, adjust sample volumes and run times if applicable.

Not sure which system is right for you?
Not sure which system is right for you?

Connect with an expert to help you decide

Contact us

Featured Vanquish webinar

Separate Your UHPLC Experience from the Status Quo

Dr. Frank Steiner and Dr. James Grinias present new features in the Vanquish platform that allow for easy method transfer, and discuss how thermal column environments can revolutionize your UHPLC experience. Discover how you can push chromatographic boundaries to separate your science from the status quo.

 Register to watch the webinar

Featured Vanquish UHPLC system videos