Scalable, validation-ready workflows for reliable, high-throughput analyses

Our workflows and solutions are purpose-built for reliable, accurate detection of organic and emerging contaminants, including per-fluoroalkyl substances (PFAS) and pesticides. In combination with our validation-ready methods, these workflows make environmental analysis and food testing more accessible and efficient than ever before. Choose one of our intelligent sample preparation options and combine it with our recommended hardware and software configurations into a workflow that will not only meet your needs today, but offers the scalability to keep you ready for what’s next.


Introducing EFOX Workflow Solutions

Regulated analyses of both environmental and food samples require traceable, defensible results for targeted quantitation. Our seamless workflows feature automated sample preparation, which reduces the variability inherent in manual sample preparation, reliable liquid chromatography systems, familiar, powerful mass spectrometry and software that seamlessly integrates instrument control, data acquisition, processing, quantitation, and compliant reporting. Together, these instruments create a streamlined, end-to-end solution that empowers laboratories to confidently meet evolving regulatory requirements and deliver accurate results from sample to report.


DLLME-EFOX Edition triple-quadrupole LC-MS workflow

For food and environmental labs, this workflow features automated dispersive liquid-liquid micro extraction (DLLME) sample preparation, using the Thermo Scientific TriPlus RSH SMART autosampler. It includes robust chromatographic separation using the Thermo Scientific Vanquish Duo UHPLC system, paired with our familiar and trusted Thermo Scientific TSQ Altis Plus EFOX Edition Triple Quadrupole Mass Spectrometer and Thermo Scientific Chromeleon software, which unifies instrument and data control. This integrated workflow offers excellent quantitative performance for regulated labs.

Workflow for PFAS quantitation using a triple quadrupole MS approach

Learn how the TSQ Altis Plus triple quadrupole mass spectrometer enhances PFAS detection in water.

TriPlus RSH SMART Autosampler

Mitigate the variability that comes with manual sample preparation and produce clean extracts that reduce matrix interference and enable reliable, reproducible separations. The DLLME technique can be performed using a TriPlus RSH SMART Autosampler with just a single manual step for 2-54 samples.

Vanquish Duo UHPLC system

Achieve flexible, high-performance UHPLC separations using the Vanquish Duo UHPLC system with Thermo Scientific Hypersil GOLD C8 and C18 LC columns to enhance laboratory productivity. The system offers two configurations – one for maximum regulatory confidence and another for optimized throughput.

TSQ Altis Plus EFOX Edition MS

Get highly selective and precise quantitation using advanced SRM technology and optimized ion transmission for pesticides, PFAS and other analytes at ultra-trace levels, meeting regulatory requirements.

Chromeleon software

Chromeleon software offers unified instrument and data control, with simplified training and guided workflows for routine users. It requires little manual intervention and provides clear, traceable data processing for your analyses.


DLLME-EFOX Series HRAM LC-MS workflow

For analysis of organic contaminants, including PFAS and pesticides, this workflow supports regulatory-compliant targeted quantitation of both environmental and food samples in routine labs with minimal method development required. Like the DLLME-EFOX Edition triple-quadrupole LC-MS workflow, it uses the DLLME sample preparation technique but also enables full-scan HRAM detection and retrospective analysis for evolving contaminant lists by employing LC-MS featuring our high-resolution accurate mass (HRAM) Thermo Scientific Orbitrap Exploris EFOX Mass Detector. This workflow keeps your lab future-ready by maintaining the scalability required for emerging contaminant compounds.

Workflow for PFAS quantitation using a full-scan high-resolution MS approach

See how the Orbitrap Exploris EFOX Mass Detector quantitates PFASS in methanolic extracts using full scan HRMS mode.

TriPlus RSH SMART Autosampler

Mitigate the variability that comes with manual sample preparation and produce clean extracts that reduce matrix interference and enable reliable, reproducible separations. The DLLME technique can be performed using a TriPlus RSH SMART Autosampler with just a single manual step for 2-54 samples.

Vanquish Duo UHPLC system

Achieve flexible, high-performance UHPLC separations using the Vanquish Duo UHPLC system with Thermo Scientific Hypersil GOLD C8 and C18 LC columns to enhance laboratory productivity. The system offers two configurations – one for maximum regulatory confidence and another for optimized throughput.

Orbitrap Exploris EFOX Mass Detector

Use the full-scan, high-resolution accurate mass (HRAM) acquisition of the Orbitrap Exploris EFOX Mass Detector to enable retrospective data analysis and add new compounds of interest to your analyses without developing a new method or re-injecting your sample.

Chromeleon software

Chromeleon software offers unified instrument and data control, with simplified training and guided workflows for routine users. It requires little manual intervention and provides clear, traceable data processing for your analyses.


Solid-Phase Extraction-Triple Quadrupole LC-MS workflow

For environmental testing, this workflow uses solid-phase extraction for automated sample preparation with the Thermo Scientific Dionex AutoTrace 280 Solid Phase Extraction (SPE) system. This sample preparation system provides fully automated SPE for consistent extraction and concentration of trace contaminants from matrices, enhancing reproducibility while minimizing hands-on time and solvent usage. Like the DLLME-EFOX Edition triple-quadrupole LC-MS workflow, it uses the Vanquish Duo UHPLC system and the TSQ Altis Plus EFOX Edition Mass Spectrometer for a streamlined, end-to-end solution that empowers laboratories to confidently meet evolving regulatory requirements and deliver accurate results from sample to report.

Dionex AutoTrace 280 PFAS Solid-Phase Extraction Instrument

This automated sample preparation instrument boosts productivity and reduces the cost of analysis and processing up to six samples at once with just 15 minutes of operator time. The instrument meets the requirements of US EPA 500 and 600 series methods including compliance with regulated methods such as US EPA 537, 537.1 and 533.

Vanquish Duo UHPLC system

Achieve flexible, high-performance UHPLC separations using the Vanquish Duo UHPLC system with Thermo Scientific LC columns to enhance laboratory productivity. The system offers two configurations – one for maximum regulatory confidence and another for optimized throughput.

TSQ Altis Plus EFOX Edition MS

Get highly selective and precise quantitation using advanced SRM technology and optimized ion transmission for pesticides, PFAS and other analytes at ultra-trace levels, meeting regulatory requirements.

Chromeleon software

Chromeleon software offers unified instrument and data control, with simplified training and guided workflows for routine users. It requires little manual intervention and provides clear, traceable data processing for your analyses.


Accelerated Solvent Extraction-Triple Quadrupole LC-MS workflow

Our solid-matrix workflow for complex environmental and food testing uses accelerated solvent extraction, using the Thermo Scientific EXTREVA ASE Accelerated Solvent Extractor for sample preparation. The EXTREVA ASE system ensures efficient recovery of analytes from demanding samples such as soil, sediment, feed, and processed foods, supporting consistent preparation and reduced manual handling. In combination with the Vanquish Duo UHPLC system, the TSQ Altis Plus EFOX Edition Triple Quadrupole Mass Spectrometer and Chromeleon software, this workflow delivers high-performance, regulation-focused analysis.

EXTREVA ASE Accelerated Solvent Extractor

Automate and simplify sample preparation for complex environmental samples using the EXTREVA ASE system. With the capability to extract four samples parallel, it increases throughput while cutting solvent consumption up to 50 percent, while minimizing background noise to give you more accurate, trace-level detection and quantitation from your LC-MS analysis

Vanquish Duo UHPLC system

Achieve flexible, high-performance UHPLC separations using the Vanquish Duo UHPLC system with Thermo Scientific LC columns to enhance laboratory productivity. The system offers two configurations – one for maximum regulatory confidence and another for optimized throughput.

TSQ Altis Plus EFOX Edition MS

Get highly selective and precise quantitation using advanced SRM technology and optimized ion transmission for pesticides, PFAS and other analytes at ultra-trace levels, meeting regulatory requirements.

Chromeleon software

Chromeleon software offers unified instrument and data control, with simplified training and guided workflows for routine users. It requires little manual intervention and provides clear, traceable data processing for your analyses.


Our General Purpose product-lines are not intended for in vitro diagnostic purposes in accordance with our product documentation, manuals, and labels. They are designated for General Laboratory Use Only.

Our Products have not been tested or validated for such applications and their use for in vitro diagnostic purposes may result in inaccurate results and, more seriously, health and safety risks.

 

For General Lab Use Only - Not For Diagnostic Procedures.