Note: Not available in US and Canada. Available in selected countries. Please contact your Thermo Fisher Scientific representative for availability.

Robust and streamlined analysis of prenatal and miscarriage samples for the reliable detection of chromosomal abnormalities, submicroscopic aberrations, loss/absence of heterozygosity (LOH/AOH), uniparental disomy (UPD), and mosaics.

Approximately 50% of miscarriages are caused by chromosomal abnormalities. Traditional cytogenetic techniques such as karyotyping and FISH are limited by cell culture failure and usually lack the appropriate sensitivity.

CytoScan™ Optima Suite has been designed with input from the cytogenetics community worldwide and empirically optimized from CytoScan HD Suite. CytoScan Optima Array offers whole-genome coverage for accurate detection of chromosomal abnormalities with increased probe coverage targeting 396 relevant regions for prenatal and miscarriage applications.

CytoScan Optima Suite includes arrays, reagents, and easy-to-use data analysis software for a cost-effective and streamlined analysis of your prenatal and product of conception (POC) samples.

CytoScan Optima Suite provides

Whole-genome coverage and higher resolution in key genetic regions to enable the detection of the following:

CytoScan Optima Suite provides

Whole-chromosome aneuploidies and submicroscopic gains and losses. This POC sample shows a 46 MB duplication in blue followed by a submicroscopic 2.2 MB deletion in red.




LOH/AOH. This sample shows three confirmed purple LOH/AOH segments of different sizes and locations.

Triploidy and maternal cell contamination


Triploidy and maternal cell contamination.
This whole-genome view shows four lines in the allelic difference track concordant with a triploidy in this first trimester POC sample.

Low-level mosaicism


Low-level mosaicism. An increase in the signal in chromosome 2 shows a ~20% mosaic trisomy in this chorionic villi (CVS) sample.

Arrays and an optimized reagent kit for streamlined workflow

Arrays and an optimized reagent kit for streamlined workflow

The Optima Kit contains the arrays and all the reagents (including the Taq polymerase) required to perform the CytoScan Optima assay. Results can be obtained in as few as 2.5 days. The protocol also contains stopping points to accommodate your schedule. Learn more ›

An intuitive and flexible workflow for accurate analysis

An intuitive and flexible workflow for accurate analysis

Chromosome Analysis Suite (ChAS) software was developed with input from leading experts and enables you to easily view and summarize chromosomal aberrations across the genome. ChAS also includes:

  • A database to store your data
  • Trio tool analysis
  • Flexible reporting tools
  • Updated external annotations
  • A built-in reference from CVS, amniocytes, cultured cells, POC, and blood samples

Learn more ›

First-class customer training and support

Customer training is required for the CytoScan Optima Suite. Different training programs are available based upon your experience level; please contact your Thermo Fisher Scientific representative for details.

Note: NetAffx Annotation Files are intended for use in automated analysis. Some are not compatible with all spreadsheet applications. Please use the NetAffx Analysis Center to limit download data to your probesets of interest. Annotation CSV files for the exon arrays are split into a probeset level annotation file and a transcript cluster level annotation file; exon array CSV files are compatible with ExACT.

Comparative transcriptional profiling of orange fruit in response to the biocontrol yeast Kloeckera apiculata and its active compounds
Liu, P.; Chen, K.; Li, G. F.; Yang, X. P.; Long, C. A. BMC Genomics 17(), NPG, 2016

A novel comparative pattern analysis approach identifies chronic alcohol mediated dysregulation of transcriptomic dynamics during liver regeneration
Kuttippurathu, L.; Juskeviciute, E.; Dippold, R. P.; Hoek, J. B.; Vadigepalli, R. BMC Genomics 17(), NPG, 2016

Anti-VP6 VHH: An Experimental Treatment for Rotavirus A-Associated Disease
Maffey, L.; Vega, C. G.; Mino, S.; Garaicoechea, L.; Parreno, V. Plos One 11(9), NPG, 2016

A cross-modal genetic framework for the development and plasticity of sensory pathways
Frangeul, L.; Pouchelon, G.; Telley, L.; Lefort, S.; Luscher, C.; Jabaudon, D. Nature 538(7623), 96-8, 2016

Phenotypic and Molecular Alterations in the Mammary Tissue of R-Spondin1 Knock-Out Mice during Pregnancy
Chadi, S.; Polyte, J.; Lefevre, L.; Castille, J.; Ehanno, A.; Laubier, J.; Jaffrezic, F.; Le Provost, F. Plos One 11(9), NPG, 2016