Single Cell Proteomics Reveal the Full Complexity of Cellular Diversity

Go Beyond
Limited Samples to Single Cells

By collaborating with the scientific community, we've developed innovations that allow you to move away from bulk sample to single cell proteomics analysis. Our latest improvements in Thermo Scientific Orbitrap mass spectrometers deliver more proteins per cell and from tens to hundreds of cells per day from cell populations, cell types and states, on a cell-to-cell basis, generating maximum insights that assess cell heterogeneity and rare cell types. So now you can go beyond faster to biological discoveries.

  • Analyze how cellular heterogeneity affects the biological system
  • Identify and characterize rare cell types and limited samples
  • Identify and quantify proteins with greater depth and coverage in a single cell
  • Maximize sensitivity with the Thermo Scientific FAIMS Pro Interface
  • Enhance sensitivity and throughput by multiplexing cells with TMT isobaric labeling
Orbitrap Mass Spectrometry Workflow for limited samples

Top

Single Cell Dark Red Divider

Webinars

Nature research
One cell at a time: single cell proteomics becomes a reality

Dr. Ryan Kelly, Associate professor, Chemistry and Biochemistry, Brigham Young University

 
Ryan Kelly

On-demand

Nature research
Multiplexed single cell proteomics: A marriage of sensitivy and throughput
Dr. Erwin Schoof, Head of Proteomics Facility, Technical University of Denmark Postdoctorial Fellow, Copenhagen University
 
Erwin Schoof

On-demand

Top

Single Cell Dark Red Divider

Scientific posters

High-throughput single cell proteomics analysis with nanodroplet sample processing, multiplex TMT labeling and ultra-sensitive LC/MS
High-throughput single cell proteomics analysis with nanodroplet sample processing, multiplex TMT labeling and ultra-sensitive LC/MS

Presented at HUPO 2019

View poster

Top

Single Cell Dark Red Divider

Recommended products


Orbitrap Exploris 480 Mass Spectrometer

Orbitrap Exploris 480 Mass Spectrometer

Obtain maximum quantitative insights with industry-leading single cell sensitivity and extraordinary accuracy, precision and simplicity. With curated workflows that deliver greater usability, the Orbitrap Exploris 480 Mass Spectrometer accelerates your path to large scale studies, delivering maximum insights from limited samples and single cells, with proven high data quality and time savings, so you can go beyond faster to actionable outcomes.

Learn more

Orbitrap Eclipse Tribrid Mass Spectrometer

Orbitrap Eclipse Tribrid Mass Spectrometer

With innovations that deliver maximum sensitivity and throughput, the Orbitrap Eclipse Tribrid mass spectrometer allows you to move away from bulk sample to rare cell and single cell proteomics analysis. In combination with TMT multiplexing reagents and the FAIMS Pro Interface, we deliver more proteins per cell, profiling and quantifying proteins from tens to hundreds of cells per day, generating maximum insights that assess cell heterogeneity and rare cell type, so you can go beyond faster to biological discoveries.

Learn more


FAIMS Pro Interface

FAIMS Pro Interface

Achieve superior selectivity and enable more proteins to be identified while reducing time-consuming sample preparation steps with the next generation differential ion mobility FAIMS Pro interface. The FAIMS Pro interface reduces singly charged chemical noise and matrix interferences, resulting in the enhancement of peptide ions maximizing the sensitivity needed for single cell proteomics analysis.

Learn more

TMTpro 16plex Label Reagent Set

Thermo Scientific Tandem Mass Tag Reagents are designed to enable identification and quantitation of proteins in different samples using tandem mass spectrometry. To increase throughput for single cell proteomics analysis, the new TMTpro 16plex label reagent set delivers the ability to analyze more than 100 single cells per day per HRAM Tribrid MS instrument with the use of a booster channel to maximize sensitivity needed for single cell analysis.

Learn more


Top

Single Cell Dark Red Divider

Publications