Limited Samples to Single Cells
By collaborating with the scientific community, we've developed innovations that allow you to move away from bulk sample to single cell proteomics analysis. Our latest improvements in Thermo Scientific Orbitrap mass spectrometers deliver more proteins per cell and from tens to hundreds of cells per day from cell populations, cell types and states, on a cell-to-cell basis, generating maximum insights that assess cell heterogeneity and rare cell types. So now you can go beyond faster to biological discoveries.
- Analyze how cellular heterogeneity affects the biological system
- Identify and characterize rare cell types and limited samples
- Identify and quantify proteins with greater depth and coverage in a single cell
- Maximize sensitivity with the Thermo Scientific FAIMS Pro Interface
- Enhance sensitivity and throughput by multiplexing cells with TMT isobaric labeling
High-throughput single cell proteomics analysis with nanodroplet sample processing, multiplex TMT labeling and ultra-sensitive LC/MS
Presented at HUPO 2019
Obtain maximum quantitative insights with industry-leading single cell sensitivity and extraordinary accuracy, precision and simplicity. With curated workflows that deliver greater usability, the Orbitrap Exploris 480 Mass Spectrometer accelerates your path to large scale studies, delivering maximum insights from limited samples and single cells, with proven high data quality and time savings, so you can go beyond faster to actionable outcomes.
With innovations that deliver maximum sensitivity and throughput, the Orbitrap Eclipse Tribrid mass spectrometer allows you to move away from bulk sample to rare cell and single cell proteomics analysis. In combination with TMT multiplexing reagents and the FAIMS Pro Interface, we deliver more proteins per cell, profiling and quantifying proteins from tens to hundreds of cells per day, generating maximum insights that assess cell heterogeneity and rare cell type, so you can go beyond faster to biological discoveries.
Achieve superior selectivity and enable more proteins to be identified while reducing time-consuming sample preparation steps with the next generation differential ion mobility FAIMS Pro interface. The FAIMS Pro interface reduces singly charged chemical noise and matrix interferences, resulting in the enhancement of peptide ions maximizing the sensitivity needed for single cell proteomics analysis.
Thermo Scientific Tandem Mass Tag Reagents are designed to enable identification and quantitation of proteins in different samples using tandem mass spectrometry. To increase throughput for single cell proteomics analysis, the new TMTpro 16plex label reagent set delivers the ability to analyze more than 100 single cells per day per HRAM Tribrid MS instrument with the use of a booster channel to maximize sensitivity needed for single cell analysis.