Antibodies that detect FAS (CD95) can be used in several scientific applications, including Flow Cytometry, Western Blot, ELISA, Immunohistochemistry (Paraffin) and Immunocytochemistry. These antibodies target FAS (CD95) in Human, Mouse, Rat, Canine and Non-human primate samples. Our FAS (CD95) monoclonal, polyclonal and recombinant monoclonal antibodies are developed in Mouse, Rabbit and Goat. These antibodies have been verified by Relative expression, Cell treatment and Knockout to confirm specificity to FAS (CD95). Find the FAS (CD95) antibody that fits your needs. Choose from 1 of 81 FAS (CD95) antibodies, which have been validated in experiments with 318 publications and 318 images featured in our data gallery.
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FAS (Fas, CD95, APO-1) is a 46 kDa transmembrane glycoprotein that functions as a cell death receptor of the TNFR (tumor necrosis factor receptor) superfamily. FAS also exists in a soluble form that weight approximately 26kDa. Stimulation of FAS results in aggregation of its intracellular FAS-associated death domains (FADD), formation of the death-inducing signaling complex (DISC) and activation of caspases. The auto-proteolytic processing of the caspases in the complex trigger a downstream cascade that leads to apoptosis. FAS has been shown to activate NF-kappaB, MAPK3/ERK1, MAPK8/JNK, and is involved in transducing the proliferating signals in normal diploid fibroblast and T cells. At least eight alternatively spliced transcript variants encoding seven distinct isoforms have been described. The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full-length isoform. The Fas/Fas ligand system has been shown to play a role in a number of human diseases such as AIDS, hepatitis and cancer. It is also assumed that induction of apoptosis through FAS ligand pathway is predominantly involved in anti-viral immune responses.
Apo-1 antigen; Apo-1 Fas; Apo1 antigen; Apoptosis-mediating surface antigen FAS; CD95; Fas (TNF receptor superfamily member); Fas antigen; FASLG receptor; lymphoproliferation; OTTHUMP00000020045; OTTHUMP00000020046; OTTHUMP00000020051; OTTHUMP00000059646; Tumor necrosis factor receptor superfamily member 6
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