Magnetic Bead-Based Sample Preparation

Featured magnetic bead-based sample preparation solutions

Magnetic bead-based sample preparation technology provides reliable and reproducible results for the purification and analyses of molecules, including DNA, RNA, proteins, cells, and exosomes. Magnetic beads keep the good stuff you’re looking for and remove everything else. Depending on your through-put needs and downstream research goals, we have a wide variety of magnetic bead-based solutions to help save you time and get exceptional results.

Thermo Scientific KingFisher automated purification systems

KingFisher instruments isolate DNA, RNA, proteins, cells, exosomes, and peptides for up to 96 samples, typically in 25–60 minutes. Easy-to-follow protocols with MagMAX and Dynabead optimized kits help remove manual steps and reduce overall processing time and errors.

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Applied Biosystems MagMAX kits

MagMAX kits extract DNA and RNA from a variety of biological samples. They are designed to be paired with liquid handlers and automated purification systems, or they can be used manually. These kits help ensure reproducibility of high-quality nucleic acid.

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Invitrogen Dynabeads kits

Dynabeads products and kits are available for many applications, including assays that require flexibility. Some kits are precoupled with a biomolecule (ligand) with an affinity for the desired target—antibody, protein or antigen, DNA/RNA probe, or other molecule.

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Magnetic bead-based extraction kits based on sample type and desired analyte

Use our selection tool to find the right magnetic bead-based kit for your sample preparation. Purify nucleic acids, proteins, cells, and exosomes from a wide range of sample types with optimized kits.

Explore our magnetic bead-based kits, reagents and protocols

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To isolate and extract…	We recommend…
DNA and/or RNA	Applied Biosystems MagMAX kits
DNA and/or RNA (not covered by MagMAX kits)	Invitrogen Dynabeads kits
Proteins for immunoprecipitation	Dynabeads reagents Thermo Scientific Pierce Magnetic beads and reagents
Proteins for peptide mapping	Thermo Scientific SMART Digest Immoaffinity kits
Cells and exosomes	Invitrogen Dynabeads reagents
Target analytes from cancer samples	Applied Biosystems MagMAX kits (nucleic acid) Invitrogen Dynabeads reagents (CTCs & exosomes) Thermo Scientific Pierce magnetic beads for mass spectrometry (proteins)

Why choose a magnetic bead-based sample prep solution?

No centrifugation or columns are required. Magnetic bead-based separation protocol is scalable and can be easily adapted for automation on KingFisher purification systems and liquid handling systems. It works with these three easy steps: bind, wash, elute.

Bind

Dynabeads magnetic beads bind to the desired target (e.g., cells, microorganisms, nucleic acids, peptides, proteins, complexes, etc.). In the example shown, an antibody is attached to the surface of the magnetic bead.

Wash

The beads respond to a magnetic field, allowing bound materials to be rapidly and efficiently collected on the magnet and separated from the rest of the sample. Unbound material remains in the supernatant and is removed by aspiration.

Elute

The bead-bound target is released from the surface of the beads in a suitable volume for use in downstream applications. Alternatively, the bead-bound target can be used directly while still attached to the beads.

Benefits of magnetic bead-based solutions

Consistency

Excellent binding to allow for specificity and optimal isolation due to the uniform bead size and surface.

Fewer complications

Less clogging because of mobile dispersion and regular density with efficient elution in small volumes.

Versatile solutions

Isolate different analytes from various sample types for use in wide range of applications.

Publication-ready results

Industry-leading data produced with Invitrogen Dynabeads and Applied Biosystems MagMAX and Thermo Scientific KingFisher products cited in more than 70,000 global publications.

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Custom solutions and OEM partnerships

We partner with leading life science companies to create customized magnetic beads, kits, and plastics tailored to specific applications and regulatory requirements. Magnetic bead-based technology is highly versatile, supporting a broad spectrum of scientific fields and applications. Our scientific specialists collaborate with your R&D and supply teams, offering sample preparation expertise to optimize molecular assays, immunoassays, vaccine development, and other life science applications. This enables us to assist our partners from the initial stages of assay development and validation through to scale-up and commercialization.

Premium consumables and instrumentation

All our premium consumables, including Dynabeads magnetic beads for protein and cell isolation and MagMAX nucleic acid purification kits, are validated with a distinct level of reproducibility within and between batches. Our offerings also include customization of existing instrumentation and software, such as KingFisher instruments and software, supply of instrument components, and development of new instruments and software, helping ensure that our solutions meet high standards of quality and performance.

Custom manufacturing and large-scale production

If you require a custom formulation, are looking for large-scale production capabilities, or need a manufacturing partner that meets specific quality or regulatory standards; our manufacturing services are here to support you. Our manufacturing capabilities offer scalable solutions that help ensure you receive high-quality, reliable products tailored to your needs.

Comprehensive technical support

Extensive proprietary knowledge enables customized product development, decreases quality control costs, and increases manufacturing efficiency, with hands-on support from R&D scientists. Our scientific specialists work in partnership with your R&D and supply teams, offering guidance specific to your lab’s customization needs on magnetic bead selection, chemistry formulation, protocol optimization, workflow analysis, and scale-up from prototype batches to bulk manufacturing, helping ensure both product performance and security of supply.

Schedule meeting with our protein and cell isolation specialists

Schedule meeting with our nucleic acid isolation specialists

Schedule meeting with our sample preparation instrumentation specialists