Search
Search
Advance nuclear receptor drug discovery with comprehensive screening services that generate high-quality biochemical and cell-based data to characterize ligand binding, receptor activation, and functional activity. Leveraging validated assay technologies and scientific expertise, we deliver actionable insights that support target validation, lead optimization, and confident candidate selection.
Expect and receive high-quality profiling data in days and steamline your lead discovery projects with SelectScreen Nuclear Receptor Profiling Services from Thermo Fisher Scientific.
Labs from pharmaceutical, biotech, consumer goods, and academic institutions have utilized SelectScreen Nuclear Receptor Profiling Service since their initiation in 2006.
Customize your nuclear receptor–based profiling project to get the right data for your research.
Standard service options include:
Currently, biochemical and cell-based nuclear receptor assays are available:
LanthaScreen biochemical competitive binding assays |
Technology overview | Protocol and assay conditions |
LanthaScreen biochemical coactivator assays |
Technology overview | Protocol and assay conditions |
GeneBLAzer cellular assays |
Technology overview | Protocol and assay conditions |
A stringent verification process helps ensure high-quality data, with each data point performed in duplicate. Strict quality control protocols ensure that any assay results not meeting set specifications will be automatically repeated, this includes a control inhibitor titration for each assay on every plate.
Assay |
GeneBLAzer cellular assay |
LanthaScreen biochemical assay |
|||||
Cell line |
Agonist |
Antagonist |
Coactivator agonist |
Coactivator inverse agonist |
Coactivator antagonist |
Competitive binding |
|
CAR |
N/A |
✓ |
✓ |
||||
ER-alpha |
UAS-bla GripTite 293 |
✓ |
✓ |
✓ |
✓ |
✓ |
|
ER-beta |
UAS-bla GripTite 293 |
✓ |
✓ |
✓ |
✓ |
✓ |
|
ERR-alpha |
UAS-bla HEK 293T |
✓ |
✓ |
||||
ERR-beta |
N/A |
✓ |
|||||
ERR-gamma |
N/A |
✓ |
|||||
FXR |
UAS-bla HEK 293T |
✓ |
✓ |
✓ |
|||
GR |
UAS-bla HEK 293T |
✓ |
✓ |
✓ |
✓ |
✓ |
|
LXR-alpha |
UAS-bla HEK 293T |
✓ |
✓ |
✓ |
|||
LXR-beta |
UAS-bla HEK 293T |
✓ |
✓ |
✓ |
|||
MR |
UAS-bla H |
✓ |
✓ |
||||
PPAR-alpha |
N/A |
✓ |
✓ |
✓ |
|||
PPAR-delta |
UAS-bla HEK 293T |
✓ |
✓ |
✓ |
✓ |
||
PPAR-gamma |
UAS-bla HEK 293H |
✓ |
✓ |
✓ |
✓ |
✓ |
|
PR |
UAS-bla HEK 293T |
✓ |
✓ |
✓ |
✓ |
||
PXR(SXR) |
N/A |
✓ |
|||||
RAR-alpha |
UAS-bla HEK 293T |
✓ |
✓ |
✓ |
|||
RAR-beta |
UAS-bla HEK 293T |
✓ |
✓ |
✓ |
✓ |
||
RAR-gamma |
UAS-bla HEK 293T |
✓ |
✓ |
✓ |
|||
RXR-alpha |
UAS-bla HEK 293T |
✓ |
✓ |
✓ |
|||
RXR-beta |
UAS-bla HEK 293T |
✓ |
✓ |
✓ |
|||
TR-alpha |
UAS-bla HEK 293T |
✓ |
✓ |
✓ |
|||
TR-beta |
UAS-bla HEK 293T |
✓ |
✓ |
✓ |
|||
VDR |
UAS-bla HEK 293T |
✓ |
✓ |
✓ |
|||
Personalized support is at the core of every SelectScreen project. From project initiation through data delivery, you'll work with a dedicated project manager who serves as your single point of contact, providing proactive communication, coordinating timelines and milestones, and ensuring proficient project execution.
Backed by experienced scientists and technical specialists, our team works as an extension of yours to deliver a responsive, collaborative experience and high-quality results tailored to your research goals.
For Research Use Only. Not for use in diagnostic procedures.