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Every GPCR discovery begins with meaningful biological insights. SelectScreen GPCR Services offers comprehensive profiling and screening solutions that enable researchers to characterize receptor function, evaluate compound activity, and streamline lead optimization with speed, accuracy, and confidence. Backed by validated assay technologies, physiologically relevant cell models, and extensive target coverage, we help ensure you get reliable data that supports informed decisions throughout the drug discovery process.
The SelectScreen Cell-based GPCR Profiling Service utilizes Thermo Fisher Scientific's portfolio of cryopreserved GeneBLAzer and Tango functionally validated assays for GPCRs and offers:
You also choose whether you want your compounds profiled in agonist or antagonist mode. All of our functional cell lines are offered in both modes. Counter-screen your “hits” against our parental cell lines when utilizing our GeneBLAzer platform to evaluate non-specific effects.
A stringent verification process helps ensure excellent data quality. Each data point is performed in duplicate. Strict quality control protocols help ensure that any assay results not meeting set specifications will be automatically repeated. EC50 or IC50 value determinations for each GPCR are performed with known agonist and/or antagonist (when available) to determine data validity and consistency.
All of the functional, GPCR-specific GeneBLAzer and Tango cell lines used in the SelectScreen Cell-based GPCR Profiling (SSCG) Service offer superior response profiles as a result of optimization of assay conditions and selection of high-responding cell populations. All GeneBLAzer and Tango cell lines in the portfolio were researched and developed by Thermo Fisher Scientific; we verify the consistency, reliability, and performance of each cell line.
GPCR-specific GeneBLAzer and Tango cell lines:
The GeneBLAzer and Tango cell lines in the service are tested and documented to show a high level of performance. These assays meet the following specifications:
Listed below are the GPCR targets available for profiling. Our list of targets represents a cross section of GPCR families, with most of the GPCRs falling into the Class A category of GPCR targets, with a smaller number in Class B.
If your target of interest is not on the list below, additional catalog GPCR cell lines may be profiled using our Custom Services.
Family |
Receptor |
Parental cell line |
|---|---|---|
Acetylcholine (Muscarinic) |
M1 |
NFAT-bla CHO-K1 |
Acetylcholine (Muscarinic) |
M2 |
U2OS |
Acetylcholine (Muscarinic) |
M3 |
NFAT-bla CHO-K1 |
Acetylcholine (Muscarinic) |
M4 |
Gqo5-NFAT-bla CHO-K1 |
Acetylcholine (Muscarinic) |
M4 |
U2OS |
Acetylcholine (Muscarinic) |
M5 |
NFAT-bla CHO-K1 |
Adenosine |
ADORA1 |
U2OS |
Adenosine |
ADORA3 |
U2OS |
Adrenoreceptor |
ADRA1A |
NFAT-bla CHO-K1 |
Adrenoreceptor |
ADRA1B |
NFAT-bla CHO-K1 |
Adrenoreceptor |
ADRA2A |
Gqo5-NFAT-bla CHO-K1 |
Adrenoreceptor |
ADRA2A |
U2OS |
Adrenoreceptor |
ADRB1 |
CRE-bla CHO-K1 |
Adrenoreceptor |
ADRB2 |
CRE-bla CHO-K1 |
Adrenoreceptor |
ADRB3 |
CRE-bla CHO-K1 |
Angiotensin |
AGTR1 |
U2OS |
Angiotensin-Like |
AGTRL1 |
U2OS |
Bradykinin |
B1 |
NFAT-bla CHO-K1 |
Bradykinin |
B2 |
NFAT-bla CHO-K1 |
Calcitonin |
CALCR |
CRE-bla Freestyle 293F |
Calcitonin |
CALCRL:RAMP1 |
CRE-bla Freestyle 293F |
Calcitonin |
CALCRL:RAMP3 |
CRE-bla Freestyle 293F |
Calcium Sensing |
CaSR |
Gqo5-NFAT-bla CHO-K1 |
Cannabinoid |
CNR1 |
Galpha15-NFAT-bla CHO-K1 |
Cannabinoid |
CNR2 |
U2OS |
Chemokine |
CCR1 |
U2OS |
Chemokine |
CCR2 |
U2OS |
Chemokine |
CCR3 |
U2OS |
Chemokine |
CCR4 |
U2OS |
Chemokine |
CCR5 |
U2OS |
Chemokine |
CCR6 |
U2OS |
Chemokine |
CCR7 |
U2OS |
Chemokine |
CXCR1 |
U2OS |
Chemokine |
CXCR2 |
U2OS |
Chemokine |
CXCR3 |
U2OS |
Chemokine |
CXCR4 |
U2OS |
Chemokine |
CXCR6 |
U2OS |
Chemokine |
CXCR7 |
U2OS |
Chemokine Like |
CMKLR1 |
U2OS |
Cholecystokinin |
CCKAR |
NFAT-bla HEK 293T |
Cholecystokinin |
CCKBR |
NFAT-bla HEK 293T |
Complement Component |
C5AR1 |
Galpha15-NFAT-bla CHO-K1 |
Corticotropin Releasing Factor |
CRHR1 |
CRE-bla CHO-K1 |
Corticotropin Releasing Factor |
CRHR2 |
CRE-bla CHO-K1 |
Dopamine |
D1 |
CRE-bla CHO-K1 |
Dopamine |
D2 |
Gqo5-NFAT-bla CHO-K1 |
Endothelial Differentiation Gene |
EDG1 |
U2OS |
Endothelial Differentiation Gene |
EDG2 |
U2OS |
Endothelial Differentiation Gene |
EDG3 |
Galpha15-NFAT-bla HEK 293T |
Endothelial Differentiation Gene |
EDG4 |
U2OS |
Endothelial Differentiation Gene |
EDG6 |
U2OS |
Endothelial Differentiation Gene |
EDG7 |
NFAT-bla HEK 293T |
Endothelial Differentiation Gene |
EDG8 |
U2OS |
Endothelin |
EDNRA |
NFAT-bla HEK 293T |
Endothelin |
EDNRA |
U2OS |
Endothelin |
EDNRB |
NFAT-bla HEK 293T |
Formyl Peptide-Like |
FPRL1 |
Galpha15-NFAT-bla CHO-K1 |
Galanin |
GALR1 |
U2OS |
Galanin |
GALR2 |
U2OS |
Gastrin Releasing Peptide |
GRPR |
NFAT-bla CHO-K1 |
Ghrelin |
GHSR |
U2OS |
Glucagon |
GCGR |
CRE-bla CHO-K1 |
Glucagon |
GIPR |
CRE-bla HEK 293T |
Glucagon |
GLP1R |
CRE-bla CHO-K1 |
Glucagon |
GLP2R |
U2OS |
Gonadotrophin-Releasing Hormone |
GnRHR |
NFAT-bla CHO-K1 |
Histamine |
H1 |
NFAT-bla HEK 293T |
Histamine |
H2 |
CRE-bla HEK 293T |
Histamine |
H3 |
U2OS |
Histamine |
H4 |
U2OS |
KiSS1 |
GPR54 |
NFAT-bla CHO-K1 |
Leukotriene |
cysLT2 |
NFAT-bla CHO-K1 |
Leukotriene |
LTB4R |
Galpha15-NFAT-bla CHO-K1 |
Melanin-Concentrating Hormone |
MCHR1 (GPR24) |
Gqi5-NFAT-bla CHO-K1 |
Melanin-Concentrating Hormone |
MCHR2 |
U2OS |
Melanin-Concentrating Hormone |
MCHR2 |
NFAT-bla CHO-K1 |
Melanocortin |
MC1R |
CRE-bla CHO-K1 |
Melanocortin |
MC2R |
CRE-bla CHO-K1 |
Melanocortin |
MC3R |
CRE-bla CHO-K1 |
Melanocortin |
MC4R |
CRE-bla CHO-K1 |
Melanocortin |
MC5R |
CRE-bla CHO-K1 |
Melatonin |
MTNR1A |
U2OS |
Melatonin |
MTNR1B |
U2OS |
Neuromedin U |
NMUR1 |
NFAT-bla CHO-K1 |
Neuropeptide S |
NPSR1-A |
NFAT-bla CHO-K1 |
Neuropeptide S |
NPSR1-B |
NFAT-bla CHO-K1 |
Neuropeptide W |
GPR8 |
U2OS |
Neuropeptide Y |
NPY1R |
U20S |
Neuropeptide Y |
NPY2R |
U2OS |
Neurotensin |
NTSR1 |
NFAT-bla CHO-K1 |
Nicotinic Acid |
GPR109A |
U2OS |
Opioid |
OPRD1 |
U2OS |
Opioid |
OPRK1 |
Gqo5-NFAT-bla CHO-K1 |
Opioid |
OPRK1 |
U2OS |
Opioid |
OPRL1 |
Gqi5-NFAT-bla Freestyle 293F |
Opioid |
OPRL1 |
U2OS |
Opioid |
OPRM1 |
U2OS |
Orexin |
HCRTR1 |
NFAT-bla CHO-K1 |
Orexin |
HCRTR2 |
Galpha15-NFAT-bla CHO-K1 |
Orphan |
GPR1 |
U2OS |
Oprhan |
GPR119 |
CRE-bla CHO-K1 |
Oprhan |
GPR35 |
U2OS |
P2Y |
P2RY11 |
NFAT-bla CHO-K1 |
P2Y |
P2RY2 |
NFAT-bla CHO-K1 |
P2Y |
P2RY6 |
NFAT-bla CHO-K1 |
Platelet Activating Factor |
PTAFR |
U2OS |
Prolactin Releasing Peptide |
GPR10 |
NFAT-bla CHO-K1 |
Prostanoid |
GPR44 (CRTH2) |
U2OS |
Prostanoid |
PTGDR |
CRE-bla CHO-K1 |
Prostanoid |
PTGER1 |
NFAT-bla CHO-K1 |
Prostanoid |
PTGER2 |
CRE-bla CHO-K1 |
Prostanoid |
PTGIR |
CRE-bla CHO-K1 |
Prostanoid |
TBXA2R |
U2OS |
Protease Activated |
F2LR1 |
U2OS |
Relaxin |
RLN3R1 |
U2OS |
Secretin |
SCTR |
CRE-bla CHO-K1 |
Serotonin |
HTR1A |
Galpha15-NFAT-bla CHO-K1 |
Serotonin |
HTR1A |
U2OS |
Serotonin |
HTR2A |
U2OS |
Serotonin |
HTR2B |
NFAT-bla CHO-K1 |
Serotonin |
HTR7 |
CRE-bla CHO-K1 |
Somatostatin |
SSTR1 |
U2OS |
Somatostatin |
SSTR2 |
U2OS |
Somatostatin |
SSTR5 |
U2OS |
Tachykinin |
TACR1 |
U2OS |
Tachykinin |
TACR2 |
NFAT-bla CHO-K1 |
Tachykinin |
TACR3 |
U2OS |
Vasopressin & Oxytocin |
AVPR1A |
NFAT-bla CHO-K1 |
Vasopressin & Oxytocin |
AVPR2 |
CRE-bla CHO-K1 |
Vasopressin & Oxytocin |
OXTR |
Gqo5-NFAT-bla CHO-K1 |
VIP & PACAP |
PAC1 |
CRE-bla CHO-K1 |
VIP & PACAP |
VPAC1 |
CRE-bla CHO-K1 |
VIP & PACAP |
VPAC2 |
CRE-bla CHO-K1 |
Personalized support is at the core of every SelectScreen project. From project initiation through data delivery, you'll work with a dedicated project manager who serves as your single point of contact, providing proactive communication, coordinating timelines and milestones, and ensuring proficient project execution.
Backed by experienced scientists and technical specialists, our team works as an extension of yours to deliver a responsive, collaborative experience and high-quality results tailored to your research goals.
For Research Use Only. Not for use in diagnostic procedures.