The G-protein-coupled receptor (GPCR) superfamily is comprised of an estimated 600-1,000 members and is the largest known class of molecular targets with proven therapeutic value. Thermo Fisher Scientific’s experienced team of GPCR biologists has generated a highly validated and novel family of GPCR cell line products to enable your discovery programs.

The portfolio contains two distinct assay platforms each utilizing FRET as the assay readout: Tango GPCR cell lines and GeneBLAzer GPCR cell lines. Each GPCR cell line platform is available in two cell states: Division Arrested non-dividing cells and normal dividing cells. Click through our cell line product table below and capability links to the right to see how we can help accelerate your drug discovery efforts.

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  Assay Performance DataDividing CellsDivision Arrested CellsAvailable in 
FamilyReceptorGeneblazer TechnologyTango TechnologyCat. No.Cat. No.SelectScreen ServiceConfirmed  Readout
Acetylcholine (Muscarinic)M1  K1710  Ca²+(Fluo-4)
Acetylcholine (Muscarinic)M1  K1735K1365Ca²+(Fluo-4), Phospho-ERK2
Acetylcholine (Muscarinic)M1  K1861   Ca²+(Fluo-4), Phospho-ERK2
Acetylcholine (Muscarinic)CHRM2 (M2)  K1564 Ca²+(Fluo-4)
Acetylcholine (Muscarinic)M3  K1716 Ca²+(Fluo-4)
Acetylcholine (Muscarinic)M4  K1741 Ca²+(Fluo-4)
Acetylcholine (Muscarinic)M4  K1818  Phospho-ERK2
Acetylcholine (Muscarinic)M5  K1728 Ca²+(Fluo-4)
AdenosineADORA1  K1445K1601 
AdenosineADORA2A  K1530K1345 cAMP
AdenosineADORA2B  K1780   
AdenosineADORA3  K1837   
AdrenoreceptorADRA1A  K1470 K1577Ca²+(Fluo-4)
AdrenoreceptorADRA1B  K1471  Ca²+(Fluo-4)
AdrenoreceptorADRA2A  K1743 Ca²+(Fluo-4)
AdrenoreceptorADRA2A  K1604 K1607 
AdrenoreceptorADRB1  K1553 cAMP
AdrenoreceptorADRB2  K1472   cAMP, ERK2
AdrenoreceptorADRB3  K1745K1473cAMP
AngiotensionAGTR1  K1443 Ca²+(Fluo-4), Phospho-ERK2
Angiotension-LikeAGTRL1  K1754K1762 
BradykininBDKRB1  K1734K1363Ca²+(Fluo-4),
Phospho-ERK2
BradykininBDKRB2  K1790  
CalcitoninCALCR  K1480 cAMP
CalcitoninCALCRL: RAMP1  K1437 cAMP
CalcitoninCALCRL: RAMP2  K1438  cAMP
CalcitoninCALCRL: RAMP3  K1439 cAMP
Calcium SensingCASR  K1833 Ca²+(Fluo-4)
CannabinoidCNR1  K1513   
CannabinoidCNR2  K1512K1567 
ChemokineCXCR1  K1807   
ChemokineCXCR2  K1521  Ca²+(Fluo-4)
ChemokineCXCR3  K1829  Ca²+(Fluo-4)
ChemokineCXCR4  K1779  Ca²+(Fluo-4)
ChemokineCXCR6  K1563  
ChemokineCXCR7  K1832  
ChemokineCCR1  K1787K1793 Ca²+(Fluo-4)
ChemokineCCR2  K1809  
ChemokineCCR3  K1815  
ChemokineCCR4  K1799  Ca²+(Fluo-4)
ChemokineCCR5  K1788 Phospho-ERK2, Ca²+(Fluo-4)
ChemokineCCR6  K1761K1765 
ChemokineCCR7  K1531  Phospho-ERK2,
Ca²+(Fluo-4)
ChemokineCMKLR1  K1527  
CholecystokininCCKAR  K1548K1623Ca²+(Fluo-4), Phospho-ERK2
CholecystokininCCKBR  K1742K1379Ca²+(Fluo-4)
Complement ComponentC5AR1  K1746K1554Ca²+(Fluo-4)
Corticotropin Releasing FactorCRHR1  K1736K1367cAMP
Corticotropin Releasing FactorCRHR2  K1733 cAMP
DopamineD1  K1485  cAMP
DopamineD2  K1708 Ca²+(Fluo-4),
Phospho-ERK2
DopamineD5  K1784  Ca²+(Fluo-4)
Endothelial Differentiation GeneEDG1  K1520  
Endothelial Differentiation GeneEDG2  K1519  
Endothelial Differentiation GeneEDG3  K1713K1319Ca²+(Fluo-4)
Endothelial Differentiation GeneEDG3  K1848  Ca²+(Fluo-4)
Endothelial Differentiation GeneEDG4  K1442  
Endothelial Differentiation GeneEDG6  K1622BK1757 
Endothelial Differentiation GeneEDG7  
K1511K1315Ca²+(Fluo-4)
Endothelial Differentiation GeneEDG7 
 K1849 Ca²+(Fluo-4)
Endothelial Differentiation GeneEDG8  K1518  
EndothelinEDNRA  K1726K1347Ca²+(Fluo-4)
EndothelinEDNRA  K1444  
EndothelinEDNRB  K1727K1349Ca²+(Fluo-4)
Formyl Peptide-LikeFPRL-1  K1532K1357Ca²+(Fluo-4)
GalaninGALR1  K1616  
GalaninGALR2  K1811  
Gastrin Releasing PeptideGRPR  K1561K1637 
GhrelinGHSR  K1819 Ca²+(Fluo-4)
Gastric Inhibitory PolypeptideGIPR  K1864  
GlucagonGCGR  K1855 cAMP
GlucagonGLP1R  K1783 cAMP
GlucagonGLP2R  K1543 cAMP
Gonadotropin Releasing HormoneGnRHR  K1854 Ca²+(Fluo-4)
HistamineH1  K1703K1299Ca²+(Fluo-4)
HistamineH2  K1707K1307cAMP
HistamineH3  K1466K1509 
HistamineH4  K1465 Ca²+(Fluo-4)
KiSS1GPR54  K1720K1333Ca²+(Fluo-4)
LeukotrieneLTB4R  K1748 Ca²+(Fluo-4)
Melanin-concentrating HormoneMCHR1 (GPR24)  K1730 Ca²+(Fluo-4)
Melanin-concentrating HormoneMCHR2 (GPR145)  K1852 Ca²+(Fluo-4)
Melanin-concentrating HormoneMCHR2 (GPR145)  K1836 Ca²+(Fluo-4),
Phospho-ERK2
MelanocortinMC1R  K1724 cAMP
MelanocortinMC2R  K1483K1597 
MelanocortinMC3R  K1744 cAMP
MelanocortinMC5R  K1740 cAMP
MelatoninMTNR1A  K1669  
MelatoninMTNR1B  K1753  
MotilinMLNR  K1862   
Neuropeptide B/WGPR8  K1478  
Neuropeptide SNPSR1a  K1447K1493Ca²+(Fluo-4)
Neuropeptide SNPSR1b  K1481B Ca²+(Fluo-4)
Neuromedin UNMUR1  K1719  
NeurotensinNTSR1  K1781K1773Ca²+(Fluo-4)
Neuropeptide YNPY1R  K1803  
Neuropeptide YNPY2R  K1479  
Neuropeptide YNPY5R  K1782   
Nicotinic AcidGPR109A K1791  
OpioidOPRD1  K1778  
OpioidOPRM1  K1523K1599 
OpioidOPRK1  K1533 Ca²+(Fluo-4). Phospho-ERK2
OpioidOPRK1  K1576 Phospho-ERK2
OpioidOPRL1  K1714 Phospho-ERK2
OpioidOPRL1  K1786 Ca²+(Fluo-4),
Phospho-ERK2
OrexinHCRTR1  K1446 Ca²+(Fluo-4)
OrexinHCRTR2  K1737K1369Ca²+(Fluo-4)
Platelet Activating FactorPTAFR  K1789 Ca²+(Fluo-4)
ProkineticinPROKR2 K1856   
Prolactin Releasing PeptideGPR10  K1732 Ca²+(Fluo-4)
ProstanoidPTGDR  K1739K1373cAMP
ProstanoidCRTH2 (GPR44) K1859  
ProstanoidPTGER1 K1851  
ProstanoidPTGER2  K1723 cAMP
ProstanoidPTGIR K1850  
ProstanoidTBXA2R  K1549 Ca²+(Fluo-4), Phospho-ERK2
Protease ActivatedF2RL1  K1830  
P2Y (Purinergic/
Pyrimidinergic)
P2RY2  K1722K1337Ca²+(Fluo-4)
P2Y (Purinergic)P2RY4  K1863  Ca²+(Fluo-4)
P2Y (Purinergic)P2RY6  K1717K1327 
P2Y (Purinergic)P2RY11  K1729 Ca²+(Fluo-4)
P2Y (Purinergic)P2RY14  K1858   
RelaxinRLN3R1  K1569  
SecretinSCTR  K1805  
SerotoninHTR1A (5HT1A) K1857 Phospho-ERK2
SerotoninHTR2B K1847  
SerotoninHTR1D  K1524   
SerotoninHTR2A  K1562K1613 Ca²+(Fluo-4)
SerotoninHTR2C  K1877   Ca²+(Fluo-4)
SerotoninHTR2C      Ca²+(Fluo-4)
SerotoninHTR7  K1704  
SomatostatinSSTR1  K1570  
SomatostatinSSTR2  K1582  
SomatostatinSSTR5  K1575 K1573 
TachykininTACR1 K1801  
TachykininTACR2 K1844 Ca²+(Fluo-4), Phospho-ERK2
TachykininTACR3  K1603  
Vasopressin & OxytocinAVPR1a  K1715K1323Ca²+(Fluo-4), Phospho-ERK2
Vasopressin & OxytocinAVPR2  K1718K1329cAMP
Vasopressin & OxytocinOXTR K1835  
VIP & PACAPVPAC1  K1705 cAMP
VIP & PACAPVPAC2  K1706 cAMP
VIP & PACAPADCYAP1R1 (PAC1)  K1525K1619 cAMP
OrphanGPR1 K1839  cAMP
OrphanGPR21 K1840   
OrphanGPR23 K1841   
OrphanGPR35  K1872  
OrphanGPR39 K1842   
OrphanGPR119  K1486K163B1 
OrphanGPR119  K1777K1770  
OrphanGPR120 (short) K1845   
OrphanGPR132 (G2A)  K1749   
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