Thermo Scientific Pierce DMP is dimethyl pimelimidate, a membrane-permeable crosslinker that contains an amine-reactive imidoester group at each end of a 7-atom spacer arm.
Features of dimethyl pimelimidate:
• Reactive groups:imidoester (both ends) • Reactive towards: amino groups (primary amines) • Mid-length reagent of three similar imidoester crosslinkers, which include DMA, DMP and DMS • Water-soluble • Imidoesters react with amines at alkaline pH values (pH 8-10) to form amidine bond • Amidine bond retains net charge character of protein primary amine to which it reacts • Reversible at high pH values • Tool for study of quarternary structure of proteins
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