Bioprocess Controllers

On this page:

Consistent bioprocess control designed for scalability

The Thermo Scientific HyPerforma G3 family of bioprocess controllers offers flexible and reliable advanced control capabilities. The controllers are fully self-contained, movable units that can be operated alone (for one vessel) or networked for multiple vessels. They are engineered to optimize capital cost for use in non-GMP and CGMP-certified production facilities. Together, the control and automation platform scales from bench through production. Integrating flexibility and an open-architecture design, this platform allows the use of third-party vessels, as well as Thermo Scientific single-use bioprocessing equipment.

Find a controller that fits your needs

Select a workflow step to see which HyPerforma G3 Bioprocess Controller to use:

Step 1: Drug discovery and R&D
Step 2: Process development
Step 3: Clinical manufacturing

Step 1: Drug discovery and R&D

Thermo Scientific HyPerforma G3Lab Bioprocess Controller

Easy process scale-up or scale-down

The G3Lab Controller can control most brands of single-use or autoclavable bioreactors and fermentors that are <50 L, including stirred-tank and rocking models. The enclosure contains innovative transmitters along with power supplies, pumps, input/output (I/O) modules, and the hardware required to connect to the control network, supporting maximum control capability.

Key features:

Scalability to <50 L
Open-architecture capabilities to integrate with vessels from other suppliers, such as the Eppendorf BioBLU Single-Use Vessels and Sartorius UniVessel Benchtop Bioreactors
The ability to build and manage complex, multi-feed dosing strategies
Allows for third-party peripheral integration as needed
Touchscreen interface for easy data entry and control
Redundant pH and DO Sensors
Customizable gas flow control
Verified and validated with TruBio software

Step 2: Process development

Thermo Scientific HyPerforma G3Lite Bioprocess Controller

Modularity for scale-up

The G3Lite Bioprocess Controller is an open-architecture control system that can be integrated with most bioreactors and fermentors—regardless of the manufacturer. The system consists of a control tower that leverages intelligent transmitters, mass flow controllers (MFCs), pumps, and sensor controls. This controller is fully self-contained, mobile, and can be operated as stand-alone (for one vessel) or networked for multiple vessels. They are engineered to optimize capital cost for use in non-GMP and cGMP-certified production facilities.

Key features:

Scalability: Volumes 50 L to 2,000 L
Modularity: Predefined configurations available for 50, 100, 250, 500, 1,000 and 2,000 L bioreactors
Touchscreen interface for easy data entry and control
Stand-alone or networked (for multiple vessels)
Redundant pH and DO sensors
Verified and validated with TruBio software

Step 3: Clinical manufacturing

Thermo Scientific HyPerforma G3Pro Bioprocess Controller

Versatility for scale-up

The G3Pro Bioprocess Controller offers many of the G3Lite Bioprocess Controller capabilities as an open-architecture, universal controller used to control most bioreactors and fermentors. These controllers enable an additional layer of versatility, allowing mobility and flexibility in terms of providing options for any reconfiguration or application expansion. They are engineered to optimize capital cost for use in non-GMP and cGMP-certified production facilities.

Key features:

Scalability: Volumes 50 L to 5,000 L
Open-architecture capabilities to integrate with vessels from other suppliers
Single or dual cart mount option for easy mobility and reduced footprint
Touchscreen NEMA interface for easy data entry and control
Probe configuration options: Flexible to connect electrochemical, single-use, or both for pH and DO supports variable cell density measurement
Redundant sensor control mechanism
Can be adapted for multi-product applications
Supports variable cell density measurement
Verified and validated with TruBio software

Supporting products used across the workflow from R&D to manufacturing

TruBio Bioprocess Automation Software

The TruBio software, powered by the Emerson DeltaV™ Distributed Control platform, offers easy-to-configure process control so learning automation control programming is not necessary. Developed for use with all Thermo Scientific controllers, TruBio software is designed to support easy scaling, data integrity and technology transfer and allow the ability to build sophisticated process control strategies. It offers flexibility to incorporate a wide range of equipment and manage multiple data streams from several unit operations. TruBio software has been developed according to GAMP 5 methods and conforms to regulatory requirements for use in cGMP-compliant processes.

Learn more

Bioreactor systems from lab to commercial manufacturing

Discover the advantages of a comprehensive single-use bioprocessing equipment portfolio, enabling scalability from research to cGMP manufacturing that will allow you to choose an ideal match for your process parameters.