The Thermo Scientific HyPerforma Single-Use Fermentor (S.U.F.) is pioneering the single-use technology market by delivering a unique and rigorous solution for microbial fermentation applications while offering the flexibility, ease of use, and efficiency found in single-use systems.
The S.U.F. is engineered for optimal oxygen mass transfer, mixing, and temperature control, with performance comparable to conventional stainless-steel systems. S.U.F.s use fundamental engineering principles, helping to make scale-up and process development work readily streamlined. Available in 30 L and 300 L sizes, the S.U.F. consists of a fermentor tank and a standard Thermo Scientific HyPerforma S.U.F. BioProcess Container (BPC).
Enhancements to improve performance of single-use fermentors were made to the 300 L hardware, as well as the 30 L and 300 L BPCs, to match more closely the oxygen delivery and cooling capacity performance of the stainless steel fermentors.
The cooling jacket surface area was increased on the sides and bottom for the 300 L S.U.F. to support adequate cooling of the production process. This 35% increase jacketed surface area will enable faster cooling of the molecule production process.
BioProcessing Container (BPC) enhancements
The BPCs for 30 L and 300 L were redesigned to have three parabolic turbine impellers that increase oxygen delivery from spargers by at least four times (4x). As a result, customer and internal culture comparisons showed that oxygen supplementation was reduced 5–7 fold vs. HyPerforma S.U.F., and is comparable to performance of stainless-steel fermentors, per same strain and procedure.
Developed with standard stainless-steel fermentation design geometry (3:1 height to diameter, 5:1 turndown ratio), the S.U.F. supports scale-up and process development activities.
Powerful agitation facilitates high oxygen transfer (kLa)and a homogeneous reaction
S.U.F.s require a separate external temperature control unit (45 W/L min. cooling capacity recommended for high demanding cultures). You may choose an open-architecture approach or a turnkey, ready-to-use S.U.F. system.