Designed specifically for microbial fermentation

With the new Thermo Scientific™ HyPerforma™ Single-Use Fermentor (S.U.F.) we are pioneering the single-use technology market by delivering a unique and rigorous solution for microbial fermentation applications while offering the flexibility, ease of use, and efficiency found in single-use systems.

Initially available in 30 L and and 300 L sizes, the S.U.F. consists of a fermentor tank and a standard Thermo Scientific™ HyPerforma™ S.U.F. BioProcess Container.

The S.U.F. is engineered for optimal oxygen mass transfer, mixing, and temperature control and performs comparably to traditional stainless steel systems. Using traditional, fundamental engineering principles, scale-up and process development work are streamlined—offering you cost savings and efficiency.

HyPerforma Single-Use Fermentor Animation

Some of the key features of the S.U.F. include:

The S.U.F. delivers an optimal growth environment through powerful agitation with three Rushton impellers and baffles, high gas flow rates, and efficient cooling through a higher vessel surface area. The single-use fermentor is designed to help you deliver results for your fermentation processes.

The S.U.F. has been developed with standard stainless steel fermentation design geometry (3:1 height to diameter, 5:1 turndown ratio), making scale-up and process development activities easy. The single-use format helps reduce batch turnover activities, including the time-consuming clean-in-place and sterilization-in-place cycles, helping to decrease costs and increase productivity.

Controlled, flexible delivery of gas is supplied through our unique drilled-hole sparge design. Coupled with powerful agitation for gas dispersion, the single-use fermentor enables you to optimize oxygen transfer (kLa) to meet your process needs. The innovative exhaust management and condenser systems are designed to provide reliable off-gassing and help minimize liquid loss during the fermentation process.

The single-use fermentor delivers powerful agitation through 3 Rushton impellers and a baffled vessel. This mixing facilitates high oxygen transfer and a homogeneous reaction.

The S.U.F.’s proven 3:1 height-to-width aspect ratio optimizes the surface area for cooling. With this high surface area and column height, the fermentor has better cooling capacity compared to less optimal 2:1 aspect ratio culture vessel designs.

Depending on the fermentation and conditions, foaming may occur during the process. We’ve developed a proprietary single-use foam-sensing probe that allows you to automate foam control and helps reduce the risk of contamination or exhaust filter failure.

Constructed using our industry-leading films (CX5-14 and Aegis™5-14), our robust S.U.F. bioprocess containers maintain sterility throughout the fermentation process. The containers are highly configurable, allowing you flexibility to address specific application needs.

Our open architecture approach allows you to integrate the S.U.F. with the control unit of your choice. Additionally, we offer turnkey systems, shipped as an S.U.F. and integrated controller.

Available in turnkey format

  • Complete mixing system with a water jacket for temperature control
  • Drive shaft inserts into the BPC through the mixing drive motor and locks into the BPC agitator assembly S.U.F. BPC

Supplied sterile and ready to use

  • Agitator assembly is a single-use (polyethylene) impeller with a bearing/seal assembly linked to an external mixer drive
  • Gas control with drilled-hole spargers
  • Exhaust management system with options for multiple vent filters based on gas flow needs
  • Integrally sealed ports in the S.U.F. BPC allow for addition of sensor probes and line sets
  • Available in Thermo Scientific™ CX5-14 Film and Thermo Scientific™ Aegis™5-14 Film options

System options

Adaptable to your needs

  • Exhaust condenser unit
  • Exhaust gas vent filter heater
  • Integrated foam sensor
  • Load cells (3)
  • Cable management tree
  • Process control system
  • Optional electrical box for remote agitation control
  • S.U.F.s require a separate external temperature control unit
  • Choose an open-architecture approach or a turnkey, ready-to-use S.U.F.system