Gene fusions and their importance in cancer research
Chromosome aberrations, in particular translocations and their corresponding gene fusions, have been shown to play an important role in the initial steps of tumorigenesis. The identification of gene fusions shows promise for playing an important role in personalized cancer treatment decisions in the future. Many rare gene fusion events have been identified in fresh-frozen solid tumors from common cancers, by next-generation sequencing technology. However, the ability to detect transcripts from gene fusions in RNA isolated from formalin-fixed, paraffin-embedded (FFPE) tumor tissues has been limited, due to the low complexity of FFPE libraries and the associated bioinformatics challenges.