Easy and robust mass spectrometry

Easy and robust mass spectrometry

Gain more confidence and invest in your lab’s future via Thermo Scientific single quadrupole mass spectrometry (MS). MS provides sensitivity and selectivity for your analyses, giving you more insight into your samples and ability to resolve difficult separations, including co-eluting peaks, using differing mass-to-charge (m/z) ratios. Our single quadrupole MS systems set new standards for robustness and ease-of-use. They are built for every day, reliable routine operation with seamless integration into your HPLC or UHPLC system.


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What is a single quadrupole mass spectrometer?

A single quadrupole mass spectrometer contains one quadrupole mass analyzer. The quadrupole mass analyzer acts as a mass filter, allowing users to select either a specific m/z ratio (i.e. one analyte) they are interested in detecting (i.e., single ion monitoring), or a range of m/z ratios (i.e., various analytes) at the same time (i.e., full scan monitoring).

Key benefits of a single quadrupole mass spectrometer

  • Selectivity – Detection based on the m/z ratio of the analyte means co-eluting peaks can be isolated by mass selectivity and is not constrained by chromatographic resolution.
  • Robust – Designed to maximize uptime, built to withstand dirty samples, and easy to clean and maintain.
  • Peak assignment – Unique mass spectrum generated for the compound of interest, ensuring correct peak assignment even in complex matrices.
  • Molecular weight information – Confirmation and identification of known and unknown compounds is possible.
  • Rapid method development – Easy identification of eluted analytes is performed without retention time validation.
  • Quantitation – Quantitative and qualitative data can be obtained easily and with limited instrument optimization.
  • Easy-to-use – Software-guided wizards and unique Thermo Scientific software that translates the physical properties of the analyte into optimal mass spectrometer parameters.
  • Insource fragmentation – Confirm compounds by specific mass fragments using collision-induced dissociation (CID).

Discover which single quadrupole mass spectrometer is right for you

    ISQ EM
ISQ EM

Flexible LC-MS analysis with an extended mass range (HESI and HESI/APCI)
ISQ EC
ISQ EC

Routine IC-MS and LC-MS analysis optimized for small molecules
Performance Application Liquid Chromatography Ion Chromatography and Liquid Chromatography
Mass Range 10 – 2000 m/z 10 – 1250 m/z
Supported Modes Full scan / SIM Full scan / SIM
Mass Resolution Unit (≤ 1.0 Da) Unit (≤ 1.0 Da)
Mass Accuracy < ± 0.1 Da < ± 0.1 Da
Scan Rate, max
Up to 20000 (Da/s) Up to 20000 (Da/s)
Stability < 0.1 Da over 48 h < 0.1 Da over 48 h
Source Details Type HESI and HESI/APCI HESI
Max Flow Rate 2mL/min 2mL/min

Application notes

What is a single quadrupole mass spectrometer?

A single quadrupole mass spectrometer contains one quadrupole mass analyzer. The quadrupole mass analyzer acts as a mass filter, allowing users to select either a specific m/z ratio (i.e. one analyte) they are interested in detecting (i.e., single ion monitoring), or a range of m/z ratios (i.e., various analytes) at the same time (i.e., full scan monitoring).

Key benefits of a single quadrupole mass spectrometer

  • Selectivity – Detection based on the m/z ratio of the analyte means co-eluting peaks can be isolated by mass selectivity and is not constrained by chromatographic resolution.
  • Robust – Designed to maximize uptime, built to withstand dirty samples, and easy to clean and maintain.
  • Peak assignment – Unique mass spectrum generated for the compound of interest, ensuring correct peak assignment even in complex matrices.
  • Molecular weight information – Confirmation and identification of known and unknown compounds is possible.
  • Rapid method development – Easy identification of eluted analytes is performed without retention time validation.
  • Quantitation – Quantitative and qualitative data can be obtained easily and with limited instrument optimization.
  • Easy-to-use – Software-guided wizards and unique Thermo Scientific software that translates the physical properties of the analyte into optimal mass spectrometer parameters.
  • Insource fragmentation – Confirm compounds by specific mass fragments using collision-induced dissociation (CID).

Discover which single quadrupole mass spectrometer is right for you

    ISQ EM
ISQ EM

Flexible LC-MS analysis with an extended mass range (HESI and HESI/APCI)
ISQ EC
ISQ EC

Routine IC-MS and LC-MS analysis optimized for small molecules
Performance Application Liquid Chromatography Ion Chromatography and Liquid Chromatography
Mass Range 10 – 2000 m/z 10 – 1250 m/z
Supported Modes Full scan / SIM Full scan / SIM
Mass Resolution Unit (≤ 1.0 Da) Unit (≤ 1.0 Da)
Mass Accuracy < ± 0.1 Da < ± 0.1 Da
Scan Rate, max
Up to 20000 (Da/s) Up to 20000 (Da/s)
Stability < 0.1 Da over 48 h < 0.1 Da over 48 h
Source Details Type HESI and HESI/APCI HESI
Max Flow Rate 2mL/min 2mL/min

Application notes