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Confident quantitation with triple quadrupole LC-MS systems

From addressing complexities of molecules and matrices, to ensuring ease-of-use while satisfying regulatory requirements—today’s challenges in targeted quantitation involve more than just measuring concentrations of target analytes. Achieve ultimate confidence in your data quality with a robust, sensitive, reproducible, and reliable targeted quantitation method using our new liquid chromatography mass spectrometry (LC/MS) workflow solutions. Our TSQ Triple Quadrupole MS systems also come with a Three Year Factory Warranty so you can gain peace of mind.


For today and what's next

TSQ Altis Triple Quadrupole Mass Spectrometer

Ultimate sensitivity & selectivity to meet tomorrow’s standards today

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For everyday excellence

TSQ Quantis Triple Quadrupole
Mass Spectrometer

Everyday quantitation workhorse to meet today’s standards

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For a new level of confidence

TSQ Fortis Triple Quadrupole Mass Spectrometer

Quality data across workflows for users at all levels of expertise

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Triple quadrupole LC-MS system product comparison

Different applications require different levels of system sensitivity, resolution, and speed. In this table, we compare different TSQ triple quadrupole systems in order to showcase which ones are most relevant to your laboratory's needs. For more information on these systems, click on our Smartnote: Transitioning to Confident Quantitation – in search of a better tomorrow

Triple Quad Product ComparisonFortisQuantis
Altis
Sensitivity++++++++++++
Resolution+++++++
Scan Speed++++++++++++
Applications across multiple matrices
Targeted quantitation in ProteomicsNoYesYes
Peptide and protein quantitation (Biopharma)NoYesYes
Small molecule quantitation (Pharma, Clinical Research)YesYesYes
Small molecule mixture quantitation (Environmental Safety, Food Safety, Forensic Toxicology, Pharma)YesYesYes
Analysis and targeted quantitation of trace impurities (Impurity Quantitation)YesYesYes
Targeted quantitation in Omics (metabolomics, lipidomics)YesYesYes
Critical Features
SRM for reliable identificationYesYesYes
Multiple Source CompatibilityYesYesYes
High Resolution SRM: for increased selectivity and sensitivity for analytes or multiple analytes in complex matrices+++++++
Segmented quadrupoles for increased ion efficiencyYesYesYes
Neutral blocker for increased robustnessYesYesYes
Increased dynodes in detector for increased lifetime and better linear dynamic rangeYesYesYes
APCI compatible with HESI sourceYesYesYes
Polarity Switching: Fast switching with stabilization enable faster quantitation assays for every molecule typeYesYesYes
System Remote MonitoringYesYesYes
Instrument IQ/OQ assistYesYesYes
Thermo Fisher Cloud: Access, process, review data whenever you like, from wherever you areNoYesYes
Wi-Fi Connectivity: Access your data, Check your assay performance remotelyYesYesYes
Size27x30x33 (in)27x30x33 (in)27x30x33 (in)
IVD PlatformNoNoNo
Compatible separation technologiesUltiMate, Vanquish, Multiplexing, Capillary LC, Other vendorsUltiMate, Vanquish, Other vendors, IC, Multiplexing, Capillary LC, NanoLCUltiMate, Vanquish, Other vendors, IC, Multiplexing, Capillary LC, NanoLC
Compatible Software?Xcalibur, TraceFinder, ChromeleonXcalibur, TraceFinder, ChromeleonXcalibur, TraceFinder, Chromeleon
Library availabilityYesYesYes

Common applications of triple quadrupole technology

To perform quantitation assays with confidence, you need a liquid chromatography mass spectrometry (LCMS) workflow solution that is relevant to your laboratory’s goals. These workflow solutions are adapted to specific applications, including clinical research, environmental and food safety, forensic toxicology, and pharma/biopharma.

Maximize your return on investment in a unified Thermo Scientific mass spectrometry architecture from data acquisition and analysis solutions


Greater proteome coverage and sensitivity

The Thermo Scientific FAIMS Pro Duo interface enhances precursor selectivity, improving qualitative and quantitative results for most peptide and protein applications while reducing time-consuming sample preparation steps. The FAIMS Pro Duo interface increases analytical performance through gas-phase fractionation and selective enhancement of peptidic compounds, reducing the complexity of MS spectra, and improving the analyte signal-to-noise ratio. The end result is greater proteome coverage, enhanced sensitivity and more accurate quantitation.

40 year anniversary of Thermo Scientific development and success of triple quadrupole mass spectrometers


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