Transcend TLX TurboFlow UHPLC Systems

Automate sample clean-up and maximize throughput.

Transcend TLX TurboFlow UHPLC Systems

Enable fast cleanup of complex matrices for accelerated online sample preparation, lower your laboratory costs, and improve data quality using Thermo Scientific Transcend TLX Systems with TurboFlow technology. These systems use a combination of chromatographic techniques for online sample cleanup to improve LC-MS detection, reduce manual work, and provide higher productivity while the systems' additional channel capabilities improve throughput by up to 400%. Thermo Scientific Aria MX software makes method setup easy and schedules several aspects of the system.


Automated sample clean-up

Online sample clean-up minimizes manual sample preparation and facilitates direct sample injection into the LC-MS system for complex sample matrices, including plasma and urine, to save time.

Improved return on investment

Multichannel technology increases throughput two- to four-fold using a single instrument with no need for new method development, accelerating laboratory output and revenue generation.

Extended sample capacity

Sample capacity can be extended from six to twelve 96- or 384- well plates by adding another cool stack to the Thermo Scientific TriPlus RSI autosampler for greater throughput.

Easy setup and system control

Thermo Scientific Aria MX software manages and controls pump operation, valve switching, cleaning, and gradients. Quickly develop methods and run batches of samples while managing multiple LC-MS methods on multiple channels simultaneously. Aria MX software is compatible with Thermo Scientific XCalibur or TraceFinder software.

How does multichannel LC-MS work?

Our multichannel LC system is designed specifically for LC-MS and allows you to run two of the same or two different applications using one mass spectrometer. Two channels run staggered LC-MS analyses, ensuring the mass spectrometer is never idle. The diagram below illustrates the resulting MS signal when running two different applications on the Transcend TurboFlow TLX UHPLC system.

Maximize MS utilization by using two channels with intelligent scheduling to run the second analysis during column reconditioning. 

System specifications

The table below provides an overview of the Transcend TurboFlow TLX UHPLC systems specifications for a standard setup. Not all specifications are listed. Specifications may differ based on the specific system components selected. See detailed Component Specifications for more information.

Category Transcend TurboFlow TLX UHPLC Systems
System pressure, maximum 1000 bar
Flow range 0-8 mL/min
Pump options (default delay volume)

Binary (100 µL)

Quaternary (379 µL)

Biocompatible Yes
pH range 2–12, chloride concentration up to 1 mol/L
System design Modular
Touchscreen user interface display compatible (optional) No
Solvent monitoring system compatible (optional) No
Customizable gradient delay volume to simplify method transfer No
SmartInject technology for maximum injection precision and improved column lifetime No
Injection volume range

Standard: 0.01-100 µL

Optional: up to 10,000 µL

Sample cooling Yes

Sample capacity (standard)

Based on standard 12 mm OD vials (≤ 1.5 mL)

6 racks that hold 54 vials each

Sampler extension available (optional) Yes, with drawers
Column compartment thermostatting


Optional sleeve heater

Column compartment pre-heater

Not available

Column compartment post-column cooler Not available
Compatible detectors

Mass Spectrometer

Component specifications

Standard Transcend TurboFlow TLX UHPLC systems are made up of the following components. Download the associated specifications sheet for more detail on each component. 

  Transcend TLX-1

Transcend TLX-2

Transcend TLX-4



Download Specification Sheet

Vanquish Binary Pump F


Vanquish Quaternary Pump F

Vanquish Binary Pump F


Vanquish Quaternary Pump F

Vanquish Binary Pump F


Vanquish Quaternary Pump F



Triplus RSI

Extended sample capacity (optional)


3- or 6-drawer cool stack  


Flow path switching


3-valve interface module 6-valve interface module 10-valve interface module



1 mass spectrometer 

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For Research Use Only. Not for use in diagnostic procedures.