Fast track to confident results
Thermo Scientific Orbitrap Exploris mass spectrometry is quantitative high-resolution, accurate-mass (HRAM) liquid chromatography mass spectrometry (LC-MS) with record-setting performance for your next-generation laboratory. The power of built-in intelligence, sensitivity and selectivity delivers depth of analysis to the lowest levels with high quantitative accuracy and precision. This extraordinary power is now available in an expanded portfolio to meet your exact analytical requirements. Scale up your research and translate your results more rapidly and simply than ever before with Orbitrap Exploris mass spectrometry.
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The evolution of 20 years of Orbitrap technology
Orbitrap Exploris 480 mass spectrometer
Next-level insights, exploratory and targeted quantitation, next-gen power, performance, and ease of use for proteomics and biopharma applications.
Why choose an Orbitrap Exploris mass spectrometer for your lab?
Market leading resolution for uncompromising data certainty
The combination of high-resolution, mass accuracy and stability ensures you have the highest level of spectral quality to help simplify your most complex analytical challenges.
Day-to-day performance consistency
Set it and forget it for days of maximum mass accuracy with built-in internal system calibration.
Intuitive tuning, single-click calibration, drag-and-drop method setup, and pre-defined experiments driven by next-generation software are designed to help you get to reportable results easier, every day, for all users.
Improve lab operations with a compact footprint
Overcome space challenges even though your lab may be experiencing growth in sample volume, while still delivering maximum business value with the MS performance you need and expect, without compromising quality of results.
Maximize your return on investment in a unified Thermo Scientific mass spectrometry architecture from data acquisition and analysis solutions
Which Orbitrap Exploris MS is best suited for your lab?
The Orbitrap Exploris mass spectrometry systems offer a variety of performance features designed to address everyday research to routine testing demands and ideal for addressing mass spectral analysis of low-level components in complex matrices applications. Find the best system to design your next-generation laboratory capabilities and meet your changing business needs for more efficient screening (including targeted, suspected and nontargeted), identification, confirmation and quantitation.
Orbitrap Exploris 120
Orbitrap Exploris 240
Orbitrap Exploris 480
|Analyses||Targeted/non-targeted screening (MS)
Unknown Identification (MS)
Absolute and Relative Quantitation (MS and/or MS2)
|Advanced Data-Dependent Experiments||N/A||Precursor Fit||SureQuant, Precursor Fit, Boxcar Scanning|
|Next generation ion source interface||Yes|
|Quick start methods for various applications||Yes|
|Drag-n-drop method setup user interface||Yes|
|Almanac Web-Based Monitoring and Management||Requires Foundation 3.1 SP1 or later|
|Automated background exclusion||N/A||Requires Foundation 3.1 SP1 or later|
|Max Resolution (FWHM) @ m/z 200||120,000||240,000||480,000|
|Mass Accuracy (Internal Calibration)||<1 ppm for up to 5 days with EASY-IC ion source|
|Calibration procedures||Thermo Scientific Pierce FlexMix Calibration solution|
|Dynamic Range||Up to 5 orders|
|Mass Range||m/z 40 – 3,000||m/z 40 - 6000
(up to 8000 with BioPharma option)
|Scan Speed||Up to 22 Hz||Up to 40 Hz|
|Polarity Switching||1.4 Hz|
|Ion Source interface||OptaMax NG ion source|
|Multiplexing||Up to 20 precursors/scan|
|Scan Functions||Full MS, Full MS/AIF, SIM, DIA, t-MS2, t-SIM/dd-MS2||Full MS, Full Ms/AIF, SIM, t-MS2, DIA, dd-MS2, Full MS/AIF NL/dd-MS2, Full MS/dd-MS2|
|Dissociation||In-source CID, HCD|
|Options and/or Upgrades|
|Intact Protein Mode||N/A||Yes|
|High Mass Range (HMR, up to 8000 m/z)||N/A||Yes|
|Sensitivity||MS/MS: 200 fg reserpine on column S/N 100:1
SIM: 200 fg reserpine on column S/N 250:1
|MS/MS: 50 fg reserpine on column S/N 100:1
SIM: 50 fg reserpine on column S/N 150:1
|Chromatography system recommendations||Vanquish Core HPLC system
Vanquish Flex HPLC system
Vanquish Duo HPLC system
Transcend Multichannel system
|Vanquish Flex HPLC system
Vanquish Duo HPLC system
Vanquish Horizon HPLC system
EASY-nLC 1200 system
UltiMate 3000 RSLCnano system
|Sources||APCI/APPI Combination Ion Source||FAIMS Pro Interface
APCI/APPI Combination Ion Source
Nanospray Flex Ion Sources
What’s inside the Orbitrap Exploris mass spectrometer
The highly optimized design of Orbitrap Exploris mass spectrometers permits a compact physical footprint while providing high performance components and many new functionalities that advance performance for critical applications. The design allows us to achieve a more compact footprint with a single turbo-pump with six-stage pumping, thus fewer moving parts, less electricity consumption, noise and weight.
Ion path and key components of Orbitrap Exploris 120 and Orbitrap Exploris 240 mass spectrometers
Orbitrap Exploris mass spectrometer ordering information
Video: Compounding Insights—How to extract high confidence understanding from comprehensive Orbitrap Exploris HRAM data
Laboratories performing LC-MS applications strive for certainty when identifying detected compounds. For many small-molecule applications, conventional approaches aren’t enough. Laboratories require more, such as rich, high quality spectral information and fit for purpose data analysis software to make satisfactory identifications and characterization.
Thermo Scientific Compound Discoverer software helps you extract high-confidence understanding from comprehensive Orbitrap high-resolution, accurate-mass data.
Smart Note: How does AcquireX intelligent data acquisition improve laboratory efficiency
Acquiring high-quality data doesn’t need to be a challenge
Your samples contain vast amounts of information, which provides both knowledge and value. Learn how The Thermo Scientific AcquireX intelligent data acquisition workflow enables you to access this information by acquiring the highest quality, in-depth LC-MSn data possible.
White paper: Challenges and emerging directions in single-cell proteomics
Learn about the challenges of single-cell proteomics compared to single-cell genomics and transcriptions. Review new technologies and methods that address these challenges. Find out more about improvements that include automation, miniaturized sample preparation, multiplexing, and fast, robust LC-MS protocols, plus consider the outlook for single-cell proteomics.