Custom affinity ligand and resin development
CaptureSelect purification products enable the efficient capture of therapeutic proteins from any feed stream, thereby helping reduce the number of process steps, increase yield, as well as provide a platform approach for purifying any target biotherapeutic.

We offer a unique service for the development of product- and/or process-specific affinity solutions tailored to a target protein and its specific requirements.

The custom ligand can be immobilized on a variety of backbones, including POROS resins, and further developed into an affinity resin, which can be used in large-scale processing of biopharmaceuticals.

Custom CaptureSelect resin development program

Library construction
1 to 10 targets

200 → 24 → 6

resin testing
6 → 2

2 → 1

suitable resin

Library constructionLead screeningPrototype resin testingLead selectioncGMP suitable resin

Ligand screen:

  • Specificity
  • Binding kinetics
  • Mild elution
  • Stability

Prototype screen:

  • Ligand scalability
  • One-step purity with feedstock
  • Elution profiles
  • Ligand stability

Lead testing:

  • Larger scale production of lead prototypes
  • Resin evaluation under process conditions

Final resin:

  • Process validation
  • Leakage ELISA
  • Regulatory support file

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Start from existing candidates in our pipeline

Through our library development process we have identified a number of candidates that may serve as excellent starting points for a custom affinity resin program. Pipeline opportunities include:

Table 1. CaptureSelect affinity products for purification

Product stage

Therapeutic proteins

Antibody types


RUO products

Antithrombin III (AT III)
Fibrinogen (POROS FibXL)
C1-inhibitor (POROS C1-InhXL)


Adenovirus (Adv5)
Baculovirus removal
Lentivirus (Lenti VSVG)

Stage WP 4:
Lead resin

Protein C (PC)


Exosomes (CD81)

Stage WP 3:
Prototype resin

CHO-Lipase (LAL, PLBL2)
Factor V (FV)
Factor H (FH)

Mouse and Rat
IgG-Fc, IgY

Exosomes (CD9)

Stage WP 2:
Ligand screening

Interferon α and β (IFNα/β)
Interleukin 2 (hIL2)
Factor XI / XII / XIII


Exosomes (CD63)
GP64 protein
Plasmid DNA

Stage WP1:

CHO host cell proteins (CHOP)
Human plasma

Human antibodies


Bioprocessing resources

Access a targeted collection of scientific application notes, case studies, posters, white papers and more for bioprocessing:

For Research Use or Further Manufacturing. Not for diagnostic use or direct administration in to humans or animals.