CaptureSelect purification products enable the efficient capture of therapeutic proteins from any feed stream, thereby helping reduce the number of process steps, increase yield, as well as provide a platform approach for purifying any target biotherapeutic.

We offer a unique service for the development of product- and/or process-specific affinity solutions tailored to a target protein and its specific requirements.

The custom ligand can be immobilized on a variety of backbones, including POROS resins, and further developed into an affinity resin, which can be used in large-scale processing of biopharmaceuticals.

Custom CaptureSelect resin development program
Library construction
1 to 10 targets
200 → 24 → 6
resin testing
6 → 2
2 → 1
suitable resin

Ligand screen:

  • Specificity
  • Binding kinetics
  • Mild elution
  • Stability

Prototype screen:

  • Ligand scalability
  • One-step purity with feedstock
  • Elution profiles
  • Ligand stability

Lead testing:

  • Larger scale production of lead prototypes
  • Resin evaluation under process conditions

Final resin:

  • Process validation
  • Leakage ELISA
  • Regulatory support file

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Start from existing candidates in our pipeline

Through our library development process we have identified a number of candidates that may serve as excellent starting points for a custom affinity resin program. Pipeline opportunities include:

Table 1. CaptureSelect affinity products for purification

Product Stage

Therapeutic Proteins


Antibody Types

Research scale purification resins

Antithrombin III (ATIII)
Fibrinogen (Factor I)
Transferrin (TF)
Apolipoprotein H (ApoH)
C1-inhibitor (C1-Inh)
Granulocyte-macrophage colony-stimulating factor (GM-CSF)

Adenovirus (Adv5)

IgA (Fc)
Bovine IgA
Rabbit IgG (Fc)

Lead Selection

Prothrombin (Factor II)
Deoxyribonuclease (DNAse)

Influenza (HA)

IgG-Fc (mouse)

Prototype resin testing

Universal affinity tag (Uni-Tag)
Factor X



Lead Screening

Interferon alpha and beta (IFNalpha/beta)
Interleukin 2 (hIL2)
Factor V, FXI, FXII, FXIII, and FH
Erythropoietin (EPO)

Lentivirus (VSV-G)

scFv / human VH

Library Construction

CHO host cell proteins


IgG-Fc (rat)

Technical resources and literature

Bioprocessing resources

Access a targeted collection of scientific application notes, case studies, posters, white papers and more for bioprocessing:

For Research Use or Further Manufacturing. Not for diagnostic use or direct administration in to humans or animals.